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diphyllin

Product Name
diphyllin
CAS No.
22055-22-7
Chemical Name
diphyllin
Synonyms
Phyllis;NSC 309691;Diphyllin >=98% (HPLC);Diphyllin【naphthofuran】;Diphyllin, 10 mM in DMSO;9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one;9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one;Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-;Benz[f]isobenzofuran-1(3H)-one,9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-;9-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
CBNumber
CB81346204
Molecular Formula
C21H16O7
Formula Weight
380.35
MOL File
22055-22-7.mol
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diphyllin Property

Melting point:
290℃ (methanol )
Boiling point:
638.8±55.0 °C(Predicted)
Density 
1.445±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
pka
7.82±0.20(Predicted)
form 
powder
color 
white to light brown
InChI
InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
InChIKey
VMEJANRODATDOF-UHFFFAOYSA-N
SMILES
O1CC2=C(O)C3C(C(C4=CC=C5OCOC5=C4)=C2C1=O)=CC(OC)=C(OC)C=3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1766
Product name
Diphyllin
Purity
≥98% (HPLC)
Packaging
5MG
Price
$111.15
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1766
Product name
Diphyllin
Purity
≥98% (HPLC)
Packaging
25MG
Price
$238.5
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
CHM0996155
Product name
9-(1,3-BENZODIOXOL-5-YL)-4-HYDROXY-6,7-DIMETHOXYNAPHTHO[2,3-C]FURAN-1(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$499.91
Updated
2021/12/16
ChemScene
Product number
CS-0022803
Product name
Diphyllin
Purity
99.85%
Packaging
10mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0022803
Product name
Diphyllin
Purity
99.85%
Packaging
25mg
Price
$950
Updated
2021/12/16
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diphyllin Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the rhizomes of Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying.

Uses

Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens.

Definition

ChEBI: Diphyllin is a lignan.

General Description

Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in Cleistanthus collinus.

Biochem/physiol Actions

Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.

in vivo

Diphyllin (20 mg/kg; oral; once a day; for 10 consecutive days) significantly inhibits the tumor growth of SGC7901 cells in mice, reduced tumor weight, downregulated the expression of V-ATPase in tumor tissues, and reduced the levels of MMP-2 and MMP-9 in serum[4].

IC 50

HIV-1: 0.38 μM (IC50); Vacuolar type H+-ATPase: 17 nM (IC50); Vesicular stomatitis virus (VSV)

diphyllin Preparation Products And Raw materials

Raw materials

Preparation Products

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diphyllin Suppliers

China 88 United States 7 Global 95
Beijing LAL Pharmaceutical Co., Ltd.
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010-010-62452898 13581984929
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010-62452898
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jlzhang929@163.com
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China
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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021-55068248
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shyysw007@163.com
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China
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Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
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+86-28-82633165
Email
cwb1@biopurify.cn
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China
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
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sales@fortunechem-sh.com
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China
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
Fax
0086-21-51320502
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tauto@tautobiotech.com
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China
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3988
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Chengdu Herbpurify Co.Ltd.
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2355253622; 18981954830
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086-28-85377358
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2355253622@qq.com;
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745
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+86-27-84254680
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aileen@chemfaces.com
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China
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6905
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Grice Rand (Tianjin) Pharmaceutical Co., Ltd.
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022-83705301 13752403750
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022-83705301
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2966024760@qq.com
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China
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Shandong Xiya Chemical Co., Ltd.
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4009903999 13395398332
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0539-6365991
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sales@xiyashiji.com
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China
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View Lastest Price from diphyllin manufacturers

Career Henan Chemical Co
Product
Benz[f]isobenzofuran-1(3H)-one,9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy- 22055-22-7
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

22055-22-7, diphyllinRelated Search:

2,3-Dihydroxynaphthalene 6-METHOXY-1-NAPHTHOL 6-METHOXY-2-NAPHTHOIC ACID 1,3-DIMETHYLNAPHTHALENE 6-Hydroxy-2-naphthoic acid 1,7-Dihydroxynaphthalene 1,6-Dihydroxynaphthalene 2-Methyl-3-biphenylmethanol 2,6-Dimethylbenzoic acid 2-BIPHENYL-(3'-METHOXY)CARBOXYLIC ACID 7-Methyl Phthalide Cleistanthin 1,2,3-TRIMETHYLNAPHTHALENE 7-METHOXY-1-NAPHTHOL diphyllin 8-METHYL-2-NAPHTHOL 7-METHYL-2-NAPHTHOL 2-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID

  • 4-Hydroxy-6,7-dimethoxy-9-(1,3-benzodioxole-5-yl)-1,3-dihydronaphtho[2,3-c]furan-1-one
  • 9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
  • Diphyllin【naphthofuran】
  • NSC 309691
  • Benz[f]isobenzofuran-1(3H)-one,9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-
  • Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-
  • Diphyllin >=98% (HPLC)
  • 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one
  • Phyllis
  • 9-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
  • Diphyllin, 10 mM in DMSO
  • 22055-22-7