4-METHOXY-1H-INDAZOL-3-AMINE
- Product Name
- 4-METHOXY-1H-INDAZOL-3-AMINE
- CAS No.
- 886362-07-8
- Chemical Name
- 4-METHOXY-1H-INDAZOL-3-AMINE
- Synonyms
- 4-methoxy-1H-indazol-4-amine;4-METHOXY-1H-INDAZOL-3-AMINE;1H-Indazol-3-aMine, 4-Methoxy-;4-Methoxy-1H-indazol-3-ylamine;4-(Methyloxy)-1H-indazol-3-amine;3-Amino-4-methoxy-1H-indazole 95%
- CBNumber
- CB8135645
- Molecular Formula
- C8H9N3O
- Formula Weight
- 163.18
- MOL File
- 886362-07-8.mol
4-METHOXY-1H-INDAZOL-3-AMINE Property
- Melting point:
- 85-87°C
- Boiling point:
- 406.3±25.0 °C(Predicted)
- Density
- 1.344
- pka
- 15.19±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 755192
- Product name
- 3-Amino-4-methoxy-1H-indazole
- Purity
- 96%
- Packaging
- 1g
- Price
- $66.5
- Updated
- 2023/01/07
- Product number
- H33750
- Product name
- 3-Amino-4-methoxy-1H-indazole, 97%
- Packaging
- 1g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- H33750
- Product name
- 3-Amino-4-methoxy-1H-indazole, 97%
- Packaging
- 5g
- Price
- $555
- Updated
- 2021/12/16
- Product number
- H33750
- Product name
- 3-Amino-4-methoxy-1H-indazole, 97%
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 046012
- Product name
- 4-Methoxy-1H-indazol-3-amine
- Purity
- >95%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
4-METHOXY-1H-INDAZOL-3-AMINE Chemical Properties,Usage,Production
Uses
4-Methoxy-1H-indazol-3-amine is used as a reactant in the preparation and structure-activity relationship of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.
Synthesis
A mixture of 2-fluoro-6-(methyloxy)benzonitrile (8a) (10 g, 66 mmol) and hydrazine hydrate (9.63 mL, 198 mmol) in n-butanol (100 mL) was heated to reflux under nitrogen for 18 h. The reaction mixture was allowed to cool, water (300 mL) was added and the organic phase was removed. The solid in the aqueous phase was collected by filtration and dried in vacuo at 40 ??C to give a white solid (0.6 g). The butanol phase was evaporated in vacuo and the residue and the aqueous mother liquors were combined and extracted using ethyl acetate (2 ?á 200 mL). The combined ethyl acetate extractions were dried (MgSO4) and evaporated in vacuo. The residue was dissolved in DCM and applied to a 100 g silica cartridge. This was eluted with cyclohexane (500 mL), cyclohexane ethyl acetate (1:1, 500 mL) and ethyl acetate (500 mL). The required fractions were combined and evaporated in vacuo to give 9a (9.92 g, 92%) as an off-white solid. MS ES + ve m/z 164 (M + H)+. 1H NMR |? (DMSO-d6) 11.35 (1H, s), 7.10 (1H, t, J = 8 Hz), 6.76 (1H, d, J = 8 Hz), 6.29 (1H, d, J = 8 Hz), 4.95 (2H, br s), 3.85 (3H, s).
4-METHOXY-1H-INDAZOL-3-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-METHOXY-1H-INDAZOL-3-AMINE Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 990
- Advantage
- 56
- Tel
- 021-11111111 11111111111
- Fax
- qq:546919421
- 546919421@qq.com
- Country
- China
- ProdList
- 3217
- Advantage
- 55
- Tel
- 18019252918
- Fax
- QQ:1454668768
- sale@amkchem.com
- Country
- China
- ProdList
- 15297
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 0512-0512-63009836 15365350169
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3984
- Advantage
- 60
- Tel
- 0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 13492
- Advantage
- 58
View Lastest Price from 4-METHOXY-1H-INDAZOL-3-AMINE manufacturers
- Product
- 4-METHOXY-1H-INDAZOL-3-AMINE 886362-07-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31