4-METHOXY-1H-INDAZOL-3-AMINE

Product Name: 4-METHOXY-1H-INDAZOL-3-AMINE
CAS No.: 886362-07-8
Chemical Name: 4-METHOXY-1H-INDAZOL-3-AMINE
Synonyms: 4-methoxy-1H-indazol-4-amine;4-METHOXY-1H-INDAZOL-3-AMINE;1H-Indazol-3-aMine, 4-Methoxy-;4-Methoxy-1H-indazol-3-ylamine;4-(Methyloxy)-1H-indazol-3-amine;3-Amino-4-methoxy-1H-indazole 95%
CBNumber: CB8135645
Molecular Formula: C8H9N3O
Formula Weight: 163.18
MOL File: 886362-07-8.mol

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4-METHOXY-1H-INDAZOL-3-AMINE Property

Melting point:: 85-87°C
Boiling point:: 406.3±25.0 °C(Predicted)
Density: 1.344
storage temp.: 2-8°C, protect from light
pka: 15.19±0.40(Predicted)
form: solid
Appearance: White to off-white Solid
InChI: InChI=1S/C8H9N3O/c1-12-6-4-2-3-5-7(6)8(9)11-10-5/h2-4H,1H3,(H3,9,10,11)
InChIKey: JZAMRGWQDJMEJD-UHFFFAOYSA-N
SMILES: N1C2=C(C(OC)=CC=C2)C(N)=N1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 755192
Product name: 3-Amino-4-methoxy-1H-indazole
Purity: 96%
Packaging: 1g
Price: $66.5
Updated: 2023/01/07

Matrix Scientific

Product number: 046012
Product name: 4-Methoxy-1H-indazol-3-amine
Purity: >95%
Packaging: 1g
Price: $63
Updated: 2021/12/16

Apolloscientific

Product number: OR15340
Product name: 3-Amino-4-methoxy-1H-indazole
Purity: 95%
Packaging: 1g
Price: $32
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-5M
Product name: 3-Amino-4-methoxy-1H-indazole
Purity: 95%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Apolloscientific

Product number: OR15340
Product name: 3-Amino-4-methoxy-1H-indazole
Purity: 95%
Packaging: 5g
Price: $116
Updated: 2021/12/16

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4-METHOXY-1H-INDAZOL-3-AMINE Chemical Properties,Usage,Production

Uses

4-Methoxy-1H-indazol-3-amine is used as a reactant in the preparation and structure-activity relationship of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.

Synthesis

A mixture of 2-fluoro-6-(methyloxy)benzonitrile (8a) (10 g, 66 mmol) and hydrazine hydrate (9.63 mL, 198 mmol) in n-butanol (100 mL) was heated to reflux under nitrogen for 18 h. The reaction mixture was allowed to cool, water (300 mL) was added and the organic phase was removed. The solid in the aqueous phase was collected by filtration and dried in vacuo at 40 ??C to give a white solid (0.6 g). The butanol phase was evaporated in vacuo and the residue and the aqueous mother liquors were combined and extracted using ethyl acetate (2 ?á 200 mL). The combined ethyl acetate extractions were dried (MgSO4) and evaporated in vacuo. The residue was dissolved in DCM and applied to a 100 g silica cartridge. This was eluted with cyclohexane (500 mL), cyclohexane ethyl acetate (1:1, 500 mL) and ethyl acetate (500 mL). The required fractions were combined and evaporated in vacuo to give 9a (9.92 g, 92%) as an off-white solid. MS ES + ve m/z 164 (M + H)+. 1H NMR |? (DMSO-d6) 11.35 (1H, s), 7.10 (1H, t, J = 8 Hz), 6.76 (1H, d, J = 8 Hz), 6.29 (1H, d, J = 8 Hz), 4.95 (2H, br s), 3.85 (3H, s).

4-METHOXY-1H-INDAZOL-3-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXY-1H-INDAZOL-3-AMINE Suppliers

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View Lastest Price from 4-METHOXY-1H-INDAZOL-3-AMINE manufacturers

Career Henan Chemical Co

Product: 4-METHOXY-1H-INDAZOL-3-AMINE 886362-07-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

886362-07-8, 4-METHOXY-1H-INDAZOL-3-AMINERelated Search:

4,4'-DIMETHOXYDIPHENYLAMINE 4-Methoxy-N-(4-methoxyphenyl)-N-phenylbenzenamine

4-METHOXY-1H-INDAZOL-3-AMINE

1H-Indazol-3-aMine, 4-Methoxy-

4-(Methyloxy)-1H-indazol-3-amine

4-Methoxy-1H-indazol-3-ylamine

3-Amino-4-methoxy-1H-indazole 95%

4-methoxy-1H-indazol-4-amine

886362-07-8

Amines

Building Blocks

C8

Chemical Synthesis

Ethers

Nitrogen Compounds

Organic Building Blocks

Oxygen Compounds