ALK-IN-27

Product Name: ALK-IN-27
CAS No.: 2739866-40-9
Chemical Name: ALK-IN-27
Synonyms: ALK-IN-27;Neladalkib;Neladalkib (NVL-655);Neladalkib (Synonyms: NVL-655);1-Chloro-3-ethyl-12-fluoro-3,10,16,18-tetrahydro-10,16-dimethyl-4,8-metheno-8H-dipyrazolo[3,4-h:4',3'-k][2,5]benzoxaazacyclotetradecin-7-amine;(R)-1-chloro-3-ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]dipyrazolo[3,4-g:4',3'-j][1]oxa[4]azacyclotetradecin-7-amine;(19R)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,?.0?,12.013,1?]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine
CBNumber: CB813765583
Molecular Formula: C23H22ClFN6O
Formula Weight: 452.91
MOL File: 2739866-40-9.mol

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ALK-IN-27 Property

Boiling point:: 685.0±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka: 7.11±0.40(Predicted)
form: Solid
color: White to off-white
InChIKey: FWZSCAQEBTVTOM-GFCCVEGCSA-N
SMILES: C(N1N=C(C2CC3=CN(N=C3C3=CC=C(C=C3[C@H](OC3=C(N=CC(=C3)C=21)N)C)F)C)Cl)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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ALK-IN-27 Chemical Properties,Usage,Production

Uses

Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity[1][2].

in vivo

Neladalkib (0.06-1.5 mg/kg, orally, twice daily, days 0-28) has antitumor activity in mice^[2].

Animal Model:	ALK-driven tumor xenografts in mice^[2]
Dosage:	0.06, 0.2, 0.5, 1.5 mg/kg
Administration:	Oral
Result:	Inhibited tumor proliferation.

References

[1] Jennifer Anne Green, et al. Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine. WO2023196910A1.
[2] Jessica J Lin, et al. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov. 2024 Sep 13:OF1-OF20. DOI:10.1158/2159-8290.CD-24-0231

ALK-IN-27 Preparation Products And Raw materials

Raw materials

Preparation Products

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ALK-IN-27 Suppliers

China 44 United States 1 Global 45

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2739866-40-9, ALK-IN-27Related Search:

ALK-IN-27

(R)-1-chloro-3-ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]dipyrazolo[3,4-g:4',3'-j][1]oxa[4]azacyclotetradecin-7-amine

(19R)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,?.0?,12.013,1?]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine

Neladalkib (Synonyms: NVL-655)

Neladalkib (NVL-655)

Neladalkib

1-Chloro-3-ethyl-12-fluoro-3,10,16,18-tetrahydro-10,16-dimethyl-4,8-metheno-8H-dipyrazolo[3,4-h:4',3'-k][2,5]benzoxaazacyclotetradecin-7-amine

2739866-40-9