QUINOXALINE-6-CARBALDEHYDE
- Product Name
- QUINOXALINE-6-CARBALDEHYDE
- CAS No.
- 130345-50-5
- Chemical Name
- QUINOXALINE-6-CARBALDEHYDE
- Synonyms
- AKOS BBS-00005346;6-Formylquinoxaline;RARECHEM AM LA 0024;IFLAB-BB F0178-0077;QUINOXALINE-6-CARBALDEHYDE;6-quinoxaline forMaldehyde;6-QUINOXALINECARBOXALDEHYDE;QUINOXALINE-6-CARBOXALDEHYDE;6-Quinoxalinecarboxaldehyde (9CI);7-Chloro-1H-iMidazo[1,2-a]pyridin-8-aMine
- CBNumber
- CB8138020
- Molecular Formula
- C9H6N2O
- Formula Weight
- 158.16
- MOL File
- 130345-50-5.mol
QUINOXALINE-6-CARBALDEHYDE Property
- Melting point:
- 130-131 °C
- Boiling point:
- 319.8±22.0 °C(Predicted)
- Density
- 1.299±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.24±0.30(Predicted)
- form
- solid
- color
- Pale brown
- InChI
- InChI=1S/C9H6N2O/c12-6-7-1-2-8-9(5-7)11-4-3-10-8/h1-6H
- InChIKey
- UGOIXUFOAODGNI-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(C=O)=CC=2)N=CC=1
- CAS DataBase Reference
- 130345-50-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- Q765323
- Product name
- Quinoxaline-6-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR17708
- Product name
- Quinoxaline-6-carboxaldehyde
- Packaging
- 250mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 4H15-1-L8
- Product name
- Quinoxaline-6-carboxaldehyde
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- Q10806
- Product name
- Quinoxaline-6-carboxaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- OR17708
- Product name
- Quinoxaline-6-carboxaldehyde
- Packaging
- 100mg
- Price
- $35
- Updated
- 2021/12/16
QUINOXALINE-6-CARBALDEHYDE Chemical Properties,Usage,Production
Uses
Quinoxaline-6-carbaldehyde can be used as raw material or intermediate of organic synthesis. It is used in the synthesis of 6-(bromomethyl)quinoxaline and ligands for targeting RNA.
Synthesis
258503-93-4
130345-50-5
The general procedure for the synthesis of quinoxaline-6-carbaldehyde from quinoxaline-6-carbonyl chloride is as follows: in an 11-liter three-neck flask under argon protection, quinoxaline-6-carbonyl chloride was dissolved in 600 mL of 1,2-dimethoxyethane (DME). An equimolar amount of lithium tri-tert-butoxyaluminum hydride (LiAlH(Ot-Bu)3) was slowly added to this solution over a period of 1.5 hours at -78 °C. The reaction was stirred continuously at -78 °C for 5 hours. Upon completion of the reaction, the reaction was quenched by careful addition of ice water, followed by dilution of the reaction mixture with ethyl acetate (AcOEt) and filtration through a diatomaceous earth pad. The organic and aqueous layers were separated and the organic phase was washed with saturated sodium bicarbonate (NaHCO3) solution. After evaporation of the solvent under reduced pressure, quinoxaline-6-carbaldehyde was obtained in 73% yield and the product was a pale yellow solid. High performance liquid chromatography (HPLC) analysis showed a retention time of 1.49 min. Liquid chromatography-mass spectrometry (LC-MS) analysis showed a retention time of 0.81 min at m/z of 159.37 [M+H]+ in ESI positive ion mode. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3) data were as follows: δ 10.28 (s, 1H), 8.97 (s, 2H), 8.61 (s, 1H), 8.27 (q, J=6 Hz, 9 Hz, 2H).
References
[1] Patent: WO2004/7491, 2004, A1. Location in patent: Page 69
QUINOXALINE-6-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
QUINOXALINE-6-CARBALDEHYDE Suppliers
- Tel
- --
- Fax
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- sales@hanchem.net
- Country
- South Korea
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View Lastest Price from QUINOXALINE-6-CARBALDEHYDE manufacturers
- Product
- QUINOXALINE-6-CARBALDEHYDE 130345-50-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13
- Product
- QUINOXALINE-6-CARBALDEHYDE 130345-50-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13