arborinine
- Product Name
- arborinine
- CAS No.
- 5489-57-6
- Chemical Name
- arborinine
- Synonyms
- arborinine;1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one;9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-
- CBNumber
- CB81395499
- Molecular Formula
- C16H15NO4
- Formula Weight
- 285.29
- MOL File
- 5489-57-6.mol
arborinine Property
- Melting point:
- 177-177.5 °C
- Boiling point:
- 508.4±50.0 °C(Predicted)
- Density
- 1.296±0.06 g/cm3(Predicted)
- solubility
- DMSO: 2 mg/mL, clear (warmed)
- form
- powder
- pka
- 7.29±0.20(Predicted)
- color
- white to beige
- SMILES
- O=C1C2=C(C=C(C(OC)=C2O)OC)N(C)C3=C1C=CC=C3
N-Bromosuccinimide Price
- Product number
- SML3966
- Product name
- Arborinine
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $106
- Updated
- 2026/03/19
- Product number
- SML3966
- Product name
- Arborinine
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $428
- Updated
- 2026/03/19
- Product number
- SML3966
- Product name
- Arborinine
- Purity
- ≥98% (HPLC)
- Packaging
- 1 unit
- Price
- $399
- Updated
- 2025/07/31
- Product number
- XA163699
- Product name
- Arborinine
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 8638CN
- Product name
- Arborinine
- Packaging
- 1mg
- Price
- $178
- Updated
- 2021/12/16
arborinine Chemical Properties,Usage,Production
Uses
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].
Definition
ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone.
in vivo
Arborinine (40, 80 mg/kg; p.o.; for 21 days) shows antitumor activity in mouse[2].
| Animal Model: | BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2] |
| Dosage: | 40, 80 mg/kg |
| Administration: | P.o.; for 21 days |
| Result: | Inhibited the growth of tumors while unchanged the body weights. |
IC 50
LSD1
References
[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y
arborinine Preparation Products And Raw materials
Raw materials
Preparation Products
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