arborinine
- Product Name
- arborinine
- CAS No.
- 5489-57-6
- Chemical Name
- arborinine
- Synonyms
- arborinine;1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one;9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-
- CBNumber
- CB81395499
- Molecular Formula
- C16H15NO4
- Formula Weight
- 285.29
- MOL File
- 5489-57-6.mol
arborinine Property
- Melting point:
- 177-177.5 °C
- Boiling point:
- 508.4±50.0 °C(Predicted)
- Density
- 1.296±0.06 g/cm3(Predicted)
- pka
- 7.29±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- SML3966
- Product name
- Arborinine
- Purity
- ≥98% (HPLC)
- Packaging
- 1 unit
- Price
- $399
- Updated
- 2025/07/31
- Product number
- XA163699
- Product name
- Arborinine
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 8638CN
- Product name
- Arborinine
- Packaging
- 1mg
- Price
- $178
- Updated
- 2021/12/16
- Product number
- PXT0002150
- Product name
- ARBORININE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.48
- Updated
- 2021/12/16
arborinine Chemical Properties,Usage,Production
Uses
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].
Definition
ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone.
in vivo
Arborinine (40, 80 mg/kg; p.o.; for 21 days) shows antitumor activity in mouse[2].
| Animal Model: | BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2] |
| Dosage: | 40, 80 mg/kg |
| Administration: | P.o.; for 21 days |
| Result: | Inhibited the growth of tumors while unchanged the body weights. |
IC 50
LSD1
References
[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y
arborinine Preparation Products And Raw materials
Raw materials
Preparation Products
arborinine Suppliers
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 028-028-85370565-229-229 18080489829
- 18080489829@163.com
- Country
- China
- ProdList
- 8250
- Advantage
- 60
- Tel
- 021-61350663 15502154572
- Fax
- -
- 1639466865@qq.com
- Country
- China
- ProdList
- 494
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- 021-57763112 13585886131
- 3004987436@qq.com
- Country
- China
- ProdList
- 9692
- Advantage
- 58
- Tel
- 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10503
- Advantage
- 58
- Tel
- +86-0755-66853366 +86-13670046396
- export03@qcsrm.com
- Country
- China
- ProdList
- 24342
- Advantage
- 58