arborinine

Product Name: arborinine
CAS No.: 5489-57-6
Chemical Name: arborinine
Synonyms: arborinine;1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one;9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-
CBNumber: CB81395499
Molecular Formula: C16H15NO4
Formula Weight: 285.29
MOL File: 5489-57-6.mol

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arborinine Property

Melting point:: 177-177.5 °C
Boiling point:: 508.4±50.0 °C(Predicted)
Density: 1.296±0.06 g/cm3(Predicted)
pka: 7.29±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3966
Product name: Arborinine
Purity: ≥98% (HPLC)
Packaging: 1 unit
Price: $399
Updated: 2025/07/31

Biosynth Carbosynth

Product number: XA163699
Product name: Arborinine
Packaging: 1mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: 8638CN
Product name: Arborinine
Packaging: 1mg
Price: $178
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002150
Product name: ARBORININE
Purity: 95.00%
Packaging: 5MG
Price: $499.48
Updated: 2021/12/16

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arborinine Chemical Properties,Usage,Production

Uses

Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].

Definition

ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone.

in vivo

Arborinine (40, 80 mg/kg; p.o.; for 21 days) shows antitumor activity in mouse^[2].

Animal Model:	BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)^[2]
Dosage:	40, 80 mg/kg
Administration:	P.o.; for 21 days
Result:	Inhibited the growth of tumors while unchanged the body weights.

IC 50

LSD1

References

[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y

arborinine Preparation Products And Raw materials

Raw materials

Preparation Products

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arborinine Suppliers

China 24 The Netherlands 1 United Kingdom 1 United States 2 Global 28

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5489-57-6, arborinineRelated Search:

3-Hydroxydiphenylamine 2,4-Dihydroxybenzophenone CARBAZINE m-(o-Toluidino)phenol 2,3,4-TRIHYDROXYDIPHENYLMETHANE Methoxymethyldiphenylamine 3-Amino-2-methylphenol 3-Methoxydiphenylamine 2'-METHYL-4-METHOXY DIPHENYL AMINE arborinine 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE 4-METHOXYDIPHENYLAMINE 9(10H)-ACRIDONE 2,3,4-Trihydroxybenzophenone 10-METHYL-9(10H)-ACRIDONE 3,4-Dimethoxybenzophenone 4-HYDROXY-2'-METHYLDIPHENYLAMINE (4-METHOXY-PHENYL)-METHYL-PHENYL-AMINE

1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one

arborinine

9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-

5489-57-6