Abiraterone acetate
- Product Name
- Abiraterone acetate
- CAS No.
- 154229-18-2
- Chemical Name
- Abiraterone acetate
- Synonyms
- ZYTIGA;17-(3-pyridyl)-5,16-androstadien-3beta-acetate;Abiraterone Acotate;(3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester);(3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester);[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;CS-212;CB 7630;Abiraterone WS
- CBNumber
- CB81396153
- Molecular Formula
- C26H33NO2
- Formula Weight
- 391.55
- MOL File
- 154229-18-2.mol
Abiraterone acetate Property
- Melting point:
- 127-130°C
- Boiling point:
- 506.7±50.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
- pka
- 5.31±0.12(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
- RTECS
- BV7992100
- HS Code
- 2937290000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1527
- Product name
- Abiraterone acetate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $543
- Updated
- 2024/03/01
- Product number
- PHR2410
- Product name
- Abiraterone Acetate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500MG
- Price
- $534
- Updated
- 2024/03/01
- Product number
- 1000818
- Product name
- Abiraterone acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $1730
- Updated
- 2024/03/01
- Product number
- A2891
- Product name
- Abiraterone Acetate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $291
- Updated
- 2024/03/01
- Product number
- A2891
- Product name
- Abiraterone Acetate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $866
- Updated
- 2024/03/01
Abiraterone acetate Chemical Properties,Usage,Production
Description
In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
Chemical Properties
Off-White Solid
Originator
Institute of Cancer Research, London (United Kingdom)
Uses
Abiraterone acetate was approved by the U.S. Food and Drug Administration (FDA) in April 2011 for the treatment of castrationresistant prostate cancer. The drug, marketed under the trade name Zytiga, was originally discovered by researchers at the Cancer Research UK Centre for Cancer Therapeutics in 1990, developed by Cougar Biotechnology, and ultimately commercialized by Johnson & Johnson after its acquisition of Cougar in 2009. Abiraterone acetate inhibits CYP17A1—an enzyme expressed in testicular, adrenal, and prostatic tumor tissues—which has been implied in the production of testosterone and the proliferation of such tumor cell lines.
Uses
A novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
Uses
Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
Definition
ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .
brand name
Zytiga
Biochem/physiol Actions
Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.
Clinical Use
Hormone antagonist:
Treatment of metastatic prostate cancer
Synthesis
The most convenient synthesis for scale-up will be highlighted from two published syntheses. Commercially available androstenolone 1 was acylated with acetic anhydride in the presence of boron trifluoride-diethyl etherate to give a near quantitative yield of acetate 2. The conversion of ketone 2 to vinyl triflate 3 involved careful selection of base to prevent elimination of the acetate group. To this extent, subjection of 2 to triflic anhydride in dichloromethane at ambient temperature followed by slow addition of triethylamine minimized undesired side products and delivered triflate 3 in 60% isolated yield. Subsequent Suzuki coupling with diethylborane 4 under standard conditions ultimately furnished abiraterone acetate (I) in 75% yield.
target
P450 (e.g. CYP17)
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: concentration possibly reduced by
rifabutin and rifampicin - avoid.
Antidepressants: concentration possibly reduced by
St John’s wort - avoid.
Antiepileptics: concentration possibly reduced
by carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone - avoid.
Metabolism
Abiraterone acetate is hydrolysed to abiraterone, which then undergoes metabolism including sulphation, hydroxylation and oxidation mainly in the liver to form inactive metabolites. About 88% of a dose is excreted in the faeces, of which about 55% is unchanged abiraterone acetate and about 22% is abiraterone; about 5% of a dose is excreted in the urine.
storage
Store at -20°C
Abiraterone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Abiraterone acetate Suppliers
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View Lastest Price from Abiraterone acetate manufacturers
- Product
- Abiraterone Acetate 154229-18-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-14
- Product
- Stanozolol 10418-03-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-16
- Product
- Abiraterone acetate 154229-18-2
- Price
- US $1.00-0.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200
- Release date
- 2024-03-22