ChemicalBook > CAS DataBase List > 2',4,4',6'-TETRAHYDROXYCHALCONE
2',4,4',6'-TETRAHYDROXYCHALCONE
- Product Name
- 2',4,4',6'-TETRAHYDROXYCHALCONE
- CAS No.
- 25515-46-2
- Chemical Name
- 2',4,4',6'-TETRAHYDROXYCHALCONE
- Synonyms
- Naringenin chalcon;cNaringenin chalcone;Naringenin chalcone-RM;2',4,4',6'-TETRAHYDROXYCHALCONE;1-(2,4,6-Trihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one;(E)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)-
- CBNumber
- CB81407576
- Molecular Formula
- C15H12O5
- Formula Weight
- 272.25
- MOL File
- 25515-46-2.mol
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2',4,4',6'-TETRAHYDROXYCHALCONE Property
- Boiling point:
- 538.7±50.0 °C(Predicted)
- Density
- 1.483±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.94±0.40(Predicted)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHL83877
- Product name
- Naringenin chalcon
- Purity
- phyproof Reference Substance
- Packaging
- 10mg
- Price
- $580
- Updated
- 2025/07/31
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2',4,4',6'-TETRAHYDROXYCHALCONE Chemical Properties,Usage,Production
Uses
food and beverages
Definition
ChEBI: 2',4,4',6'-tetrahydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. It has a role as a metabolite, an anti-allergic agent and an anti-inflammatory agent. It is a polyphenol and a member of chalcones. It is functionally related to a trans-chalcone.
in vivo
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].
| Animal Model: | Mouse type I allergic model[1] |
| Dosage: | 0.8 mg/kg |
| Administration: | Oral administration |
| Result: | Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%. |
| Animal Model: | Allergic airway inflammation induced in mice[3] |
| Dosage: | 0.8 mg/kg |
| Administration: | Oral administration, daily |
| Result: | Decreased cell numbers of the infiltrating leukocyte and eosinophils. Decreased Muc5ac and gob-5 expression in the lungs. |
2',4,4',6'-TETRAHYDROXYCHALCONE Preparation Products And Raw materials
Raw materials
Preparation Products
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