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Nefazodone hydrochloride

Product Name
Nefazodone hydrochloride
CAS No.
82752-99-6
Chemical Name
Nefazodone hydrochloride
Synonyms
TFA ≥Serazone;NEFAZODONE;Isatin ≥Indole ≥BMY 13754-1;Hecameg ≥>=98% (HPLC);Chromone ≥Piperine &ge
CBNumber
CB8144863
Molecular Formula
C25H33Cl2N5O2
Formula Weight
506.47
MOL File
82752-99-6.mol
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Nefazodone hydrochloride Property

Melting point:
186-188°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: ~11 mg/mL at 60 °C
form 
solid
color 
white
λmax
248nm(MeOH)(lit.)
Merck 
14,6438
CAS DataBase Reference
82752-99-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
XZ5483009
HS Code 
2933595960
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5536
Product name
Nefazodone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08148
Product name
Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem
Packaging
10mg
Price
$155
Updated
2024/03/01
Sigma-Aldrich
Product number
1457902
Product name
Nefazodone hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$1040
Updated
2024/03/01
TCI Chemical
Product number
N1030
Product name
Nefazodone Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
N1030
Product name
Nefazodone Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$89
Updated
2024/03/01
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Nefazodone hydrochloride Chemical Properties,Usage,Production

Description

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT2 receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HTIA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a1 -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemical Properties

White Solid

Originator

Bristol-Myers Squibb (U.S.A.)

Uses

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor

Uses

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

Definition

ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.

Manufacturing Process

Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

General Description

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biological Activity

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Nefazodone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nefazodone hydrochloride Suppliers

Americas 1 Belgium 1 Brazil 2 Canada 6 China 115 Europe 3 Germany 5 India 13 Israel 1 Japan 4 Singapore 1 South Korea 1 Spain 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 44 Global 212
Merck Millipore
Tel
--
Fax
--
Email
ccc@merckgroup.com
Country
Germany
ProdList
2008
Advantage
58
Alfa Aesar, Thermo Fisher Scientific
Tel
--
Fax
--
Email
es@alfa.com
Country
Germany
ProdList
5123
Advantage
58
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62
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View Lastest Price from Nefazodone hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Nefazodone hydrochloride 82752-99-6
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-26
Career Henan Chemical Co
Product
Nefazodone hydrochloride 82752-99-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

82752-99-6, Nefazodone hydrochlorideRelated Search:

Naphazoline hydrochloride Topotecan hydrochloride Furazolidone Naphazoline Triadimefon Trazodone Nefazodone Related Compound B,Nefazodone Related Compound B NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts),NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts) 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Nefazodone Related Compound A,Nefazodone Related Compound A HYDROXY NEFAZODONE HCL,HYDROXY NEFAZODONE HCL Nefazodone hydrochloride NEFAZODONE , TRAZODONE,NEFAZODONE , TRAZODONE HYDROXY NEFAZODONE-D5 HCL,HYDROXY NEFAZODONE-D5 HCL 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (intermediate of nefazodone hcl) Nefazodone Hcl

  • NEFAZODONE-D5 HCL
  • 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
  • Nefazodone HCl
  • Nefazodone hydrochloride
  • NEFAZODONE
  • BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
  • 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
  • Nefazodone Hydrochloride (200 mg)
  • 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
  • BMY 13754-1
  • Serazone
  • Nefazodone hydrochloride API
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
  • Nefazodone hydrochlo
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
  • >=98% (HPLC)
  • 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4
  • 3-(4-Bromophenyl)-1H-pyrazole-5-carboxylic acid &ge
  • Boc-L-propraglycine dicyclohexylammonium salt &ge
  • Ethyl 2-amino-4-methylpyrimidine-5-carboxylate &ge
  • Indole-6-carboxaldehyde &ge
  • 4-Chloro-6,7-dimethoxyquinazoline &ge
  • 4-(4-Nitrophenoxy)benzaldehyde &ge
  • Formyl-L-methionine &ge
  • 5-Azacytosine &ge
  • 3-(4-Methylphenyl)-1H-pyrazole-4-carbaldehyde &ge
  • Fmoc-L-aspartic acid a-allyl ester &ge
  • 5-Amino-3-(4-bromophenyl)pyrazole &ge
  • 2-Amino-6-methyl-5-nitropyridine &ge
  • Boc-D-cyclopropylglycine &ge
  • 3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid &ge
  • -diphosphate potassium salt &ge
  • 2-(4-Methoxyphenyl)succinic acid &ge
  • Z-L-pyroglutamic acid N-hydroxysuccinimide ester &ge
  • 5-(4-Nitrophenyl)-1H-tetrazole &ge
  • 5-(4-Fluorophenyl)-1,3,4-oxadiazole-2-thiol &ge
  • Boc-a-methyl-L-phenylalanine &ge
  • Pentafluoro-L-b-homophenylalanine hydrochloride &ge
  • Z-L-threonine methyl ester &ge
  • Na-Z-D-tryptophan &ge
  • Z-6-aminohexanoic acid &ge
  • 3-(4-Methoxyphenyl)-pyrazole-4-carboxylic acid &ge
  • (R,S)-Fmoc-2-amino-4,4,4-trifluoro-butyric acid &ge
  • Z-L-alanine-N-hydroxysuccinimide ester &ge
  • 6-Bromo-DL-tryptophan &ge
  • Fmoc-4-amino-L-phenylalanine &ge
  • 4-(4-Nitrophenoxy)Benzoic Acid &ge
  • Z-DL-proline &ge
  • O-Benzyl-L-serine methyl ester hydrochloride &ge
  • Methyl 2-Hydroxy-4-Morpholinobenzoate &ge
  • Boc-2-chloro-D-phenylalanine &ge
  • Boc-4,4-Difluoro-L-proline &ge
  • Ethyl 4-hydroxy-6-methylquinoline-3-carboxylate &ge
  • Na-Fmoc-Ng-Boc-D-2,4-diaminobutyric acid &ge
  • 4-(Bromomethyl)-3-(4-chlorophenyl)-5-methylisoxazole &ge
  • 4-Amino-2-chloro-5-nitropyridine &ge
  • 11-Tritylmercapto-undecanoic acid &ge
  • Fmoc-Ne-methyltrityl-D-lysine &ge