Naphazoline

Product Name: Naphazoline
CAS No.: 835-31-4
Chemical Name: Naphazoline
Synonyms: NAPHAZOLINE HCL;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;NAFAZOLINE;ciba2020/r
CBNumber: CB2414016
Molecular Formula: C14H14N2
Formula Weight: 210.27
MOL File: 835-31-4.mol

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Naphazoline Property

Melting point:: 254 °C
Boiling point:: 339.81°C (rough estimate)
Density: 1.1063 (rough estimate)
refractive index: 1.6180 (estimate)
storage temp.: 2-8°C
pka: pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
CAS DataBase Reference: 835-31-4(CAS DataBase Reference)
NIST Chemistry Reference: Naphazoline(835-31-4)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: NJ4375000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: RDL0006964
Product name: NAPHAZOLINE-D4
Purity: 95.00%
Packaging: 5MG
Price: $495.33
Updated: 2021/12/16

Chemenu

Product number: CM128968
Product name: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Purity: 95%
Packaging: 1g
Price: $259
Updated: 2021/12/16

Crysdot

Product number: CD33000071
Product name: Naphazoline
Purity: 95+%
Packaging: 1g
Price: $274
Updated: 2021/12/16

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Naphazoline Chemical Properties,Usage,Production

Originator

Privine,Ciba,US,1942

Uses

Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Uses

Adrenergic (vasoconstrictor).

Definition

ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Manufacturing Process

2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Nasal decongestant

Synthesis

Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Naphazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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Naphazoline Suppliers

Austria 1 China 67 Europe 1 France 1 Germany 1 India 7 The Netherlands 2 United Kingdom 4 United States 18 Global 102

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6451
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13374
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9506
Advantage: 60

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View Lastest Price from Naphazoline manufacturers

Hubei Aumei New Material Co., Ltd.

Product: naphazoline 835-31-4
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500tons/month
Release date: 2021-08-30

Dideu Industries Group Limited

Product: Naphazoline 835-31-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

Career Henan Chemical Co

Product: Naphazoline 835-31-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2020-03-05

835-31-4, NaphazolineRelated Search:

Dihydromyrcenol 2-Methylnaphthalene Tolazoline hydrochloride 1-Methylimidazole Oxymetazoline Imidazole Oxymetazoline hydrochloride Naphazoline nitrate NAPHAZOLINE HCL,NAPHAZOLINE HYDROCHLORIDE,NAPHAZOLINE HYDROCHLORIDE EXTRA PURE PH EUR,BP,USP,Naphazoline·hydrochloric acid IMIDAZOLE HYDROCHLORIDE NAPHAZOLINE HYDROCHLORIDE - REFERENCE SPECTRUM NAPHAZOLINE IMPURITY A Naphazoline NAPHAZOLINE HCL(USP)(COMING SOON)(P) NAPHAZOLINE HYDROCHLORIDE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD) NAPHAZOLINE (BASE) Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD)

4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE

2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE

2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE

1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-

NAFAZOLINE

2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole

Naphazoline

2-(1-Naphtylmethyl)-2-imidazoline

2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole

4,5-Dihydro-2-(1-naphtylmethyl)-1H-imidazole

Naphazoline-d4

naphazoline:2-(naphthalen-1-ylmethyl)-4,5-dihydro-1h-IMIDAZOLE

2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole

2-(1-Naphethylmethyl)-2-imidazoline

2-(1-naphthylmethyl)-2-imidazolin

2-(1-Naphthylmethyl)-2-imidazoline

2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole

2-(alpha-Naphthylmethyl)-imidazoline

2-(Naphthyl-(1')-methyl)imidazolin

2-(naphthyl-(1’)-methyl)imidazolin

2-Imidazoline, 2-(1-naphthylmethyl)-

4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol

alpha-Naphthylmethyl imidazoline

alpha-naphthylmethylimidazoline

Antan

CIBA 2020/r

ciba2020/r

Imidin

Naphthizine

Privine

Rhinazine

Sanorin

NAPHAZOLINE HCL

Naphazoline USP/EP/BP

Naphazoline DISCONTINUED. Please see N343955 or N343950

Inhibitor,TNFR,Adrenergic Receptor,Naphazoline,vascular hyperpermeability,Interleukin Related,decongestive,vasoconstriction,Tumor Necrosis Factor Receptor,cytokines,VEGFR,Vascular endothelial growth factor receptor,inflammation,inhibit,Naphthazoline,TNF Receptor,Beta Receptor,conjunctivitis

835-31-4

550-99-2835-31-4

C14H14N2HCl

alpha-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.

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