ChemicalBook > CAS DataBase List > Naphazoline

Naphazoline

Product Name
Naphazoline
CAS No.
835-31-4
Chemical Name
Naphazoline
Synonyms
NAPHAZOLINE HCL;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;NAFAZOLINE;ciba2020/r
CBNumber
CB2414016
Molecular Formula
C14H14N2
Formula Weight
210.27
MOL File
835-31-4.mol
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Naphazoline Property

Melting point:
254 °C
Boiling point:
339.81°C (rough estimate)
Density 
1.1063 (rough estimate)
refractive index 
1.6180 (estimate)
storage temp. 
2-8°C
pka
pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
CAS DataBase Reference
835-31-4(CAS DataBase Reference)
NIST Chemistry Reference
Naphazoline(835-31-4)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
NJ4375000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
RDL0006964
Product name
NAPHAZOLINE-D4
Purity
95.00%
Packaging
5MG
Price
$495.33
Updated
2021/12/16
Chemenu
Product number
CM128968
Product name
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Purity
95%
Packaging
1g
Price
$259
Updated
2021/12/16
Crysdot
Product number
CD33000071
Product name
Naphazoline
Purity
95+%
Packaging
1g
Price
$274
Updated
2021/12/16
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Naphazoline Chemical Properties,Usage,Production

Originator

Privine,Ciba,US,1942

Uses

Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Uses

Adrenergic (vasoconstrictor).

Definition

ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Manufacturing Process

2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Nasal decongestant

Synthesis

Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Naphazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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Naphazoline Suppliers

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View Lastest Price from Naphazoline manufacturers

Hubei Aumei New Material Co., Ltd.
Product
naphazoline 835-31-4
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500tons/month
Release date
2021-08-30
Career Henan Chemical Co
Product
Naphazoline 835-31-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2020-03-05
Career Henan Chemical Co
Product
Naphazoline 835-31-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-03

835-31-4, NaphazolineRelated Search:

Dihydromyrcenol 2-Methylnaphthalene Tolazoline hydrochloride 1-Methylimidazole Oxymetazoline Imidazole Oxymetazoline hydrochloride Naphazoline nitrate NAPHAZOLINE HCL,NAPHAZOLINE HYDROCHLORIDE,NAPHAZOLINE HYDROCHLORIDE EXTRA PURE PH EUR,BP,USP,Naphazoline·hydrochloric acid IMIDAZOLE HYDROCHLORIDE NAPHAZOLINE HYDROCHLORIDE - REFERENCE SPECTRUM NAPHAZOLINE IMPURITY A Naphazoline NAPHAZOLINE HCL(USP)(COMING SOON)(P) NAPHAZOLINE HYDROCHLORIDE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD) NAPHAZOLINE (BASE) Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD)

  • 4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE
  • 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE
  • 2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE
  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
  • NAFAZOLINE
  • 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
  • Naphazoline
  • 2-(1-Naphtylmethyl)-2-imidazoline
  • 2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole
  • 4,5-Dihydro-2-(1-naphtylmethyl)-1H-imidazole
  • Naphazoline-d4
  • naphazoline:2-(naphthalen-1-ylmethyl)-4,5-dihydro-1h-IMIDAZOLE
  • 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole
  • 2-(1-Naphethylmethyl)-2-imidazoline
  • 2-(1-naphthylmethyl)-2-imidazolin
  • 2-(1-Naphthylmethyl)-2-imidazoline
  • 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole
  • 2-(alpha-Naphthylmethyl)-imidazoline
  • 2-(Naphthyl-(1')-methyl)imidazolin
  • 2-(naphthyl-(1’)-methyl)imidazolin
  • 2-Imidazoline, 2-(1-naphthylmethyl)-
  • 4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol
  • alpha-Naphthylmethyl imidazoline
  • alpha-naphthylmethylimidazoline
  • Antan
  • CIBA 2020/r
  • ciba2020/r
  • Imidin
  • Naphthizine
  • Privine
  • Rhinazine
  • Sanorin
  • NAPHAZOLINE HCL
  • Naphazoline USP/EP/BP
  • Naphazoline DISCONTINUED. Please see N343955 or N343950
  • Inhibitor,TNFR,Adrenergic Receptor,Naphazoline,vascular hyperpermeability,Interleukin Related,decongestive,vasoconstriction,Tumor Necrosis Factor Receptor,cytokines,VEGFR,Vascular endothelial growth factor receptor,inflammation,inhibit,Naphthazoline,TNF Receptor,Beta Receptor,conjunctivitis
  • 835-31-4
  • 550-99-2835-31-4
  • C14H14N2HCl
  • alpha-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
  • API