3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Product Name: 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 954230-39-8
Chemical Name: 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
Synonyms: ethyl 3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate;Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 98%;4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-Methyl-, ethyl;3-(4-fluorophenyl)-5-methyl-4-Isoxazolecarboxylicacid ethylester;3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-methyl-, ethyl ester
CBNumber: CB81466461
Molecular Formula: C13H12FNO3
Formula Weight: 249.24
MOL File: 954230-39-8.mol

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3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 58-59℃
storage temp.: Sealed in dry,Room Temperature

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC200509
Product name: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
Purity: 98%
Packaging: 250mg
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 093214
Product name: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
Purity: 97%
Packaging: 10g
Price: $1103
Updated: 2021/12/16

Matrix Scientific

Product number: 093214
Product name: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
Purity: 97%
Packaging: 5g
Price: $706
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037620
Product name: ETHYL 3-(4-FLUOROPHENYL)-5-METHYLISOXAZOLE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 2G
Price: $794.64
Updated: 2021/12/16

Apolloscientific

Product number: PC200509
Product name: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
Purity: 98%
Packaging: 1g
Price: $132
Updated: 2021/12/16

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3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

2723-42-4

459-23-4

954230-39-8

Step b) Synthesis of ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate: To a suspension of 4-fluorobenzaldehyde oxime (1.39 g, 10.0 mmol) in DMF (10 mL) was added N-chlorosuccinimidyl chloride (1.36 g, 10.0 mmol) in batches over a period of 5 min at 15 to 20 °C. The resulting mixture was stirred at room temperature for 90 min to produce a yellow solution containing N-hydroxy-4-fluorobenzimidoyl chloride. Subsequently, a solution of ethyl 3-(1-pyrrolidinyl)crotonate (1.89 g, 10.0 mmol) in DMF (5 mL) was added dropwise to this solution over 2 min at room temperature. The reaction mixture was continued to be stirred at room temperature for 28 hours. After completion of the reaction, the mixture was diluted with water (25 mL) and extracted with ethyl acetate (4 x 25 mL). The organic layers were combined, washed sequentially with 1 M HCl (2 × 25 mL) and water (2 × 25 mL), dried over anhydrous Na2SO4, and subsequently concentrated to dryness at 45 °C/25 mbar to yield 2.37 g (95% yield) of ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate as a brown solid, with purity of 100% by GC and HPLC analysis The purity was 97% by GC and 97% by HPLC.

References

[1] Patent: US2013/102778, 2013, A1. Location in patent: Paragraph 0220
[2] Patent: WO2013/57123, 2013, A1. Location in patent: Page/Page column 31
[3] Patent: US2013/172329, 2013, A1. Location in patent: Paragraph 0257

3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 3-(4-Fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl ester 954230-39-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-14

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 954230-39-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-16

Shanghai Rlavie Technology Co ltd

Product: Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 954230-39-8
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-20

954230-39-8, 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTERRelated Search:

ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Ethyl 5-methyl-3-phenylisoxazole-4-carboxylate 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-(4-FLUOROPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLIC ACID

3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-Methyl-, ethyl

ethyl 3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate

Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 98%

3-(4-fluorophenyl)-5-methyl-4-Isoxazolecarboxylicacid ethylester

4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-methyl-, ethyl ester

954230-39-8

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