3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 954230-39-8
- Chemical Name
- 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- ethyl 3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate;Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 98%;4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-Methyl-, ethyl;3-(4-fluorophenyl)-5-methyl-4-Isoxazolecarboxylicacid ethylester;3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-methyl-, ethyl ester
- CBNumber
- CB81466461
- Molecular Formula
- C13H12FNO3
- Formula Weight
- 249.24
- MOL File
- 954230-39-8.mol
3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 58-59℃
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PC200509
- Product name
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- PC200509
- Product name
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 6434AC
- Product name
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- HCH0037620
- Product name
- ETHYL 3-(4-FLUOROPHENYL)-5-METHYLISOXAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $135.45
- Updated
- 2021/12/16
- Product number
- 093214
- Product name
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
2723-42-4
459-23-4
954230-39-8
Step b) Synthesis of ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate: To a suspension of 4-fluorobenzaldehyde oxime (1.39 g, 10.0 mmol) in DMF (10 mL) was added N-chlorosuccinimidyl chloride (1.36 g, 10.0 mmol) in batches over a period of 5 min at 15 to 20 °C. The resulting mixture was stirred at room temperature for 90 min to produce a yellow solution containing N-hydroxy-4-fluorobenzimidoyl chloride. Subsequently, a solution of ethyl 3-(1-pyrrolidinyl)crotonate (1.89 g, 10.0 mmol) in DMF (5 mL) was added dropwise to this solution over 2 min at room temperature. The reaction mixture was continued to be stirred at room temperature for 28 hours. After completion of the reaction, the mixture was diluted with water (25 mL) and extracted with ethyl acetate (4 x 25 mL). The organic layers were combined, washed sequentially with 1 M HCl (2 × 25 mL) and water (2 × 25 mL), dried over anhydrous Na2SO4, and subsequently concentrated to dryness at 45 °C/25 mbar to yield 2.37 g (95% yield) of ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate as a brown solid, with purity of 100% by GC and HPLC analysis The purity was 97% by GC and 97% by HPLC.
References
[1] Patent: US2013/102778, 2013, A1. Location in patent: Paragraph 0220
[2] Patent: WO2013/57123, 2013, A1. Location in patent: Page/Page column 31
[3] Patent: US2013/172329, 2013, A1. Location in patent: Paragraph 0257
3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(4-FLUORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 3-(4-Fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl ester 954230-39-8
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-14
- Product
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 954230-39-8
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-16
- Product
- Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate 954230-39-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-20