2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE

Product Name: 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
CAS No.: 230615-52-8
Chemical Name: 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
Synonyms: hydrochloride (1:1);10-azatricyclo[6.3.1.02?]dodeca-2(7),3,5-triene;2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl;2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine hydrochloride;2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE;2,3,4,5-tetrahydro-1H-1,5-methano-3-benzazepin-3-ium chloride;2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride;2,3,4,5-tetrahydro-1,5-Methano-1H-3-benzazepine,hydrochlorid...;2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine (hydrochlortde);1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride
CBNumber: CB81472880
Molecular Formula: C11H13N.HCl
Formula Weight: 195.69
MOL File: 230615-52-8.mol

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2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Property

Melting point:: >230°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly, Heated), Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
InChI: InChI=1/C11H13N.ClH/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1;/h1-4,8-9,12H,5-7H2;1H/t8-,9+;
InChIKey: WWJDLIUDQHFAGC-UFIFRZAQNA-N
SMILES: C1[C@@]2(C3=C(C=CC=C3)[C@@]([H])(C2)CN1)[H].Cl |&1:1,8,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T295580
Product name: 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepineHydrochloride
Packaging: 100mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-B0003
Product name: 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepinehydrochloride
Purity: 99.99%
Packaging: 1g
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-B0003
Product name: 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepinehydrochloride
Purity: 99.99%
Packaging: 5g
Price: $278
Updated: 2021/12/16

ChemScene

Product number: CS-B0003
Product name: 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepinehydrochloride
Purity: 99.99%
Packaging: 10g
Price: $336
Updated: 2021/12/16

AK Scientific

Product number: 1494AB
Product name: 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepinehydrochloride
Packaging: 10g
Price: $437
Updated: 2021/12/16

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2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine Hydrochloride is used in the preparation of the main band impurity of Varenicline (V098490), a nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.

Synthesis

230615-48-2

230615-52-8

The general procedure for the synthesis of 2,3,4,5-tetrahydro-3-benzyl-1,5-methano-1H-3-benzazepine hydrochloride from 2,3,4,5-tetrahydro-3-benzyl-1,5-methanolbenzo[d]azepine hydrochloride is as follows: methanol hydrochloride (116.6 g, 13.8%) was slowly added to 10-benzyl-10-azabenzotriene at 0°C to 5°C [ 6.3.1.02,7]dodeca-2(7),3,5-triene (100 g) in a methanol (600 ml) suspension. Subsequently, the reaction mixture was subjected to hydrogenation reaction catalyzed by 20% palladium hydroxide (26 g) under hydrogen pressure of 5 to 6 kg/cm2 at 20°C to 40°C for 3 to 6 hours. The reaction process was monitored by HPLC. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was distilled under reduced pressure to remove the solvent. Dichloromethane (500 ml) was added to the residue and the solvent was again completely evaporated under reduced pressure to give the crude product. The crude product was purified by recrystallization with acetone (450 ml) to finally obtain high purity 10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene hydrochloride (HPLC purity 98.23%, yield 89.24%).

References

[1] Patent: US2009/318695, 2009, A1. Location in patent: Page/Page column 9
[2] Patent: WO2010/23561, 2010, A1. Location in patent: Page/Page column 16

2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Suppliers

Canada 1 China 109 India 6 United Kingdom 2 United States 4 Global 122

Anhui Qiushi Medical Technology Co., Ltd

Tel: 15005516438
Fax: 15005516438
Email: sales1@qiushipharm.com
Country: China
ProdList: 82
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 023-13650506873 19923294409
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1604
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
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View Lastest Price from 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE 230615-52-8
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-25

R&D Scientific Inc.

Product: 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl 230615-52-8
Price: US $1200.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-10

Hangzhou ICH Biofarm Co., Ltd

Product: 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE 230615-52-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

230615-52-8, 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDERelated Search:

Piperidine 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE

1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride

2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine hydrochloride

2,3,4,5-tetrahydro-1,5-Methano-1H-3-benzazepine,hydrochloride (1:1)

hydrochloride (1:1)

2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride

1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride (1:1)

2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE ISO 9001：2015 REACH

2,3,4,5-tetrahydro-1,5-Methano-1H-3-benzazepine,hydrochlorid...

2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE,230615-52-8

10-azatricyclo[6.3.1.02?]dodeca-2(7),3,5-triene

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl

2,3,4,5-tetrahydro-1H-1,5-methano-3-benzazepin-3-ium chloride

2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepinehydrochloride 230615-52-8

2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine (hydrochlortde)

230615-52-8