6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

Product Name: 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
CAS No.: 230615-23-3
Chemical Name: 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
Synonyms: Varenicline HCl;ChaMpix hydrochloride;Chantix hydrochloride;CP 526555 hydrochloride;Varenicline hydrochloride;CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride;5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+;6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride;6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride
CBNumber: CB21512571
Molecular Formula: C13H14ClN3
Formula Weight: 247.73
MOL File: 230615-23-3.mol

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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0828
Product name: Varenicline(Hydrochloride)
Purity: 98.87%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FV152325
Product name: Varenicline hydrochloride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

ApexBio Technology

Product number: B1141
Product name: VareniclineHydrochloride
Packaging: 5mg
Price: $119
Updated: 2021/12/16

ChemScene

Product number: CS-0828
Product name: Varenicline(Hydrochloride)
Purity: 98.87%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: B1141
Product name: VareniclineHydrochloride
Packaging: 10mg
Price: $189
Updated: 2021/12/16

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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Chemical Properties,Usage,Production

Uses

Varenicline Hydrochloride is a useful nicotine binding inhibitor.

Biological Activity

varenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1].

References

[1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1.

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Suppliers

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View Lastest Price from 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride manufacturers

Career Henan Chemical Co

Product: 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride 230615-23-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

230615-23-3, 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochlorideRelated Search:

Varenicline-d4 Dihydrochloride (Major) Varenicline Lactam Varenicline N-Glucoside Varenicline Carbamoyl β-D-Glucuronide 6,7-DIMETHYLQUINOXALINE 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Varenicline 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride (Varenicline hydrochloride)

CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl)

Varenicline hydrochloride

6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride

5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1)

7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride

6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride

ChaMpix hydrochloride

Chantix hydrochloride

CP 526555 hydrochloride

Varenicline HCl

230615-23-3

C13H13N3HCl

API intermediates