6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
- Product Name
- 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
- CAS No.
- 230615-23-3
- Chemical Name
- 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
- Synonyms
- ChaMpix hydrochloride;Chantix hydrochloride;CP 526555 hydrochloride;Varenicline hydrochloride;CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride;5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+;6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride;6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
- CBNumber
- CB21512571
- Molecular Formula
- C13H14ClN3
- Formula Weight
- 247.73
- MOL File
- 230615-23-3.mol
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
N-Bromosuccinimide Price
- Product number
- CS-0828
- Product name
- Varenicline(Hydrochloride)
- Purity
- 98.87%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FV152325
- Product name
- Varenicline hydrochloride
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- B1141
- Product name
- VareniclineHydrochloride
- Packaging
- 5mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- CS-0828
- Product name
- Varenicline(Hydrochloride)
- Purity
- 98.87%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- B1141
- Product name
- VareniclineHydrochloride
- Packaging
- 10mg
- Price
- $189
- Updated
- 2021/12/16
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Chemical Properties,Usage,Production
Uses
Varenicline Hydrochloride is a useful nicotine binding inhibitor.
Biological Activity
varenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1].
References
[1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1.
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Preparation Products And Raw materials
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View Lastest Price from 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride manufacturers
- Product
- 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride 230615-23-3
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20