1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Product Name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- CAS No.
- 67085-11-4
- Chemical Name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Synonyms
- BUTOCOZOL IMPURITY 2;Butoconazol Impurity 2;Butoconazole Impurity 2;Butoconazole Nitrate INT II;Butoconazole 2-Hydroxy Impurity;1-[4-(4-Chlorophenyl)-2-hydroxylbutyl];4-(4-chlorophenyl)-1-imidazol-1-ylbutan-2-ol;4-(4-Chlorophenyl)-1-(1-imidazolyl)-2-butanol;1-[4-(4-CHLOROPHENYL)-2-HYDROXYLBUTYL]IMIDAZOLE;4-(4-Chlorophenyl)-1-(1H-iMidazol-1-yl)butan-2-ol
- CBNumber
- CB81476378
- Molecular Formula
- C13H15ClN2O
- Formula Weight
- 250.72
- MOL File
- 67085-11-4.mol
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Property
- Melting point:
- 106-109 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 472.2±40.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 13.69±0.20(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C378070
- Product name
- α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol
- Packaging
- 5g
- Price
- $670
- Updated
- 2021/12/16
- Product number
- C378070
- Product name
- α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol
- Packaging
- 10g
- Price
- $1030
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 50mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 250mg
- Price
- $192.5
- Updated
- 2021/12/16
- Product number
- FC150299
- Product name
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
- Packaging
- 500mg
- Price
- $335
- Updated
- 2021/12/16
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Chemical Properties,Usage,Production
Uses
α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is used as a reactant in the preparation of imidazol phenylbutane derivatives as heme oxygenase inhibitors. α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is also an impurity of Butoconazole (B690273), which is an antifungal.
Synthesis
288-32-4
59363-13-2
67085-11-4
(2) In a dry DMF solvent, sodium hydride (in the form of mineral oil dispersion) at a concentration of 20% was added and 20 mL of a DMF solution of imidazole was added dropwise at a rate of 2 mL/s under ice bath cooling conditions. Subsequently, the reaction mixture was stirred at 60 °C for 60 min. After the ice bath was cooled, Intermediate 1 (weight ratio of imidazole, sodium hydride to Intermediate 1 was 7:7:5) was slowly added via the salt bath method. The reaction mixture was continued to be stirred at 60°C for 120 minutes. After completion of the reaction, the reaction was again cooled in an ice bath and a 25% n-hexane solution was added to the reaction mixture and stirred at a rate of 3 rev/s for 15 min. Subsequently, ice (350% by weight of the reaction mixture) was added and stirring was continued at a rate of 3 rev/s until the precipitation was complete. The precipitate was collected by filtration and the filter cake was washed once with water and then dried by centrifugation at 2830 r/min for 60 minutes. The resulting product was treated with 2.5 times its weight of ethyl acetate and 0.05 times its weight of activated charcoal, left to stand at 5 °C for 13 h, followed by recrystallization at 50 °C. The yield of Intermediate 2 was 71.5% by HPLC analysis, wherein the purity of the target product 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]imidazole was 99.31%.
References
[1] Patent: CN105218455, 2016, A. Location in patent: Paragraph 0055
[2] Patent: CN105175341, 2017, B. Location in patent: Paragraph 0048-0052
[3] Patent: CN105175338, 2018, B. Location in patent: Paragraph 0069-0071
[4] Patent: CN107501190, 2017, A. Location in patent: Paragraph 0033; 0036; 0043; 0046
[5] Patent: WO2005/70897, 2005, A1. Location in patent: Page/Page column 7
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Suppliers
- Tel
- 022-66880623
- Fax
- 86(0)22-66880086
- sales@tjzxchem.com
- Country
- China
- ProdList
- 613
- Advantage
- 60
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
- Fax
- 0371-86159066
- Country
- China
- ProdList
- 2015
- Advantage
- 60
- Tel
- 0371-0371-13526885213 15637198702
- Fax
- 0371-63709726
- hsyykjchem@163.com
- Country
- China
- ProdList
- 3853
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 15716293042 18862996710
- Fax
- 0513-68015394
- 15050603958@163.com
- Country
- China
- ProdList
- 694
- Advantage
- 55
- Tel
- +86-0531-88801869 15090917080
- Fax
- 0531-88801867
- sciencechem@163.com
- Country
- China
- ProdList
- 283
- Advantage
- 55
- Tel
- 0371-53778726 18003825608
- Fax
- QQ：2885354392
- liuxiaoyan@alfachem.cn
- Country
- China
- ProdList
- 1986
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- T:15050866711
- Fax
- QQ:2677337387
- wanglin.chen@radiant-pharma.com
- Country
- China
- ProdList
- 466
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 17792809151
- Fax
- 18872220797
- 2355916837@ycphar.com
- Country
- China
- ProdList
- 6133
- Advantage
- 55
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 15153166971
- win-wind@hotmail.com
- Country
- China
- ProdList
- 97
- Advantage
- 58
- Tel
- 18064670521
- Fax
- 0757-88210752
- 2355935187@ycphar.com
- Country
- China
- ProdList
- 4879
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-6387771-6039 18920764717
- sales@heowns.com
- Country
- China
- ProdList
- 23771
- Advantage
- 60
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8617320695765
- Fax
- 17320695765
- zxx@hktiansheng.com
- Country
- China
- ProdList
- 973
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- +86-5922680277 +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17346
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- +86-531-88989536 +86-15508631887
- Fax
- +86-531-88989539
- sales@finerchem.com
- Country
- China
- ProdList
- 2952
- Advantage
- 58
- Tel
- +86-86-5926051114 +8615060885618
- sales@amoychem.com
- Country
- China
- ProdList
- 6369
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 021-58123769 17721400256
- info@paynepharm.com
- Country
- China
- ProdList
- 1285
- Advantage
- 58
- Tel
- 021-58123769 18678586262
- info@paynepharm.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 173-40521416 17340521416
- Fax
- 17340521416
- 1757224788@qq.com
- Country
- China
- ProdList
- 1992
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- 027-13163388153 13163388153
- yeqiu416@163.com
- Country
- China
- ProdList
- 9809
- Advantage
- 58
- Tel
- +86-0519-85551759 +8613506123987
- Fax
- +0086-519-85557389
- marketing1@neostarunited.com
- Country
- China
- ProdList
- 8830
- Advantage
- 58
- Tel
- 027-87747081 18186681184
- 1344475572@qq.com
- Country
- China
- ProdList
- 7220
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 17612776928
- Fax
- 17612776928
- 17612776928@qq.com
- Country
- China
- ProdList
- 4971
- Advantage
- 58
- Tel
- 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4686
- Advantage
- 58
- Tel
- 15271551270
- ycwlb056@yeah.net
- Country
- China
- ProdList
- 2086
- Advantage
- 58
- Tel
- --
- Fax
- --
- sarah@mainchem.com
- Country
- China
- ProdList
- 6547
- Advantage
- 58
View Lastest Price from 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole manufacturers
- Product
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4
- Price
- US $0.99/KG
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-12-09
- Product
- 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-29