4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

Product Name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.: 203519-88-4
Chemical Name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
Synonyms: tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate;1-Boc-4-(6-chloropyrimidin-4-yl)piperazine;ert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate;4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-Carbocylic acid tert-butyl ester;4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate - [AC80063];1-Piperazinecarboxylic acid, 4-(6-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber: CB81501452
Molecular Formula: C13H19ClN4O2
Formula Weight: 298.77
MOL File: 203519-88-4.mol

More

Less

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 437.3±45.0 °C(Predicted)
Density: 1.253
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.29±0.26(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0143393
Product name: 1-BOC-4-(6-CHLOROPYRIMIDIN-4-YL)PIPERAZINE
Purity: 95.00%
Packaging: 5MG
Price: $502.14
Updated: 2021/12/16

AK Scientific

Product number: 0427AB
Product name: tert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate
Packaging: 10g
Price: $3141
Updated: 2021/12/16

Crysdot

Product number: CD11168948
Product name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylicacidtert-butylester
Purity: 95+%
Packaging: 1g
Price: $576
Updated: 2021/12/16

Crysdot

Product number: CD11168948
Product name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylicacidtert-butylester
Purity: 95+%
Packaging: 250mg
Price: $265
Updated: 2021/12/16

Alichem

Product number: 203519884
Product name: tert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate
Packaging: 1g
Price: $366.08
Updated: 2021/12/16

More

Less

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

1193-21-1

57260-71-6

203519-88-4

Step 1: Synthesis of tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate In a microwave reaction tube, 4,6-dichloropyrimidine (0.5 g, 3.36 mmol), N-BOC-piperazine (0.69 g, 3.36 mmol) and triethylamine (0.34 g, 3.36 mmol) were dissolved in acetonitrile (10 mL). The reaction mixture was microwaved at 120 °C for 2 hours. After completion of the reaction, the mixture was diluted with ethyl acetate, washed sequentially with saturated ammonium chloride solution and dried over anhydrous magnesium sulfate. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target compound tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate (0.82 g, 91% yield). 1H NMR (500MHz, CDCl3): δ 8.39 (s, 1H), 6.50 (s, 1H), 3.65 (m, 4H), 3.52 (m, 4H), 1.48 (s, 9H).

References

[1] Patent: WO2012/69852, 2012, A1. Location in patent: Page/Page column 69
[2] Patent: CN106045918, 2016, A. Location in patent: Paragraph 0098; 0099
[3] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 21
[4] Patent: WO2007/56023, 2007, A2. Location in patent: Page/Page column 57
[5] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 36

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Suppliers

China 34 Switzerland 1 United Kingdom 1 United States 3 Global 39

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
Advantage: 58

Amber MolTech LLC

Tel: 086-010-62176588
Fax: 086-010-62117849
Email: amber@jyamber.com
Country: China
ProdList: 10151
Advantage: 56

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

Shanghai ChuangYan Chemical Technology Co., Ltd.

Tel: 021-11111111 11111111111
Fax: qq:546919421
Email: 546919421@qq.com
Country: China
ProdList: 3521
Advantage: 55

Shanghai Boyners Pharm-Tech Co., Ltd.

Tel: 13817873692
Fax: 021-31329586
Email: mkt@boynerspharm.com
Country: China
ProdList: 1707
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

More

Less

View Lastest Price from 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(6-Chloro-pyriMidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 203519-88-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

203519-88-4, 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl esterRelated Search:

tert-butyl 4-[6-chloro-5-(hydroxymethyl)-4-pyrimidinyl]tetrahydro-1(2H)-pyrazinecarboxylate tert-butyl 4-(6-chloro-5-formyl-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER tert-butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate 4-(6-CHLORO-5-NITRO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER TERT-BUTYL 4-(6-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDIN-4-YL)PIPERAZINE-1-CARBOXYLATE

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-Carbocylic acid tert-butyl ester

1-Boc-4-(6-chloropyrimidin-4-yl)piperazine

1-Piperazinecarboxylic acid, 4-(6-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester

ert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate

tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate - [AC80063]

203519-88-4

pharmacetical