4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

Product Name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.: 203519-88-4
Chemical Name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
Synonyms: tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate;1-Boc-4-(6-chloropyrimidin-4-yl)piperazine;ert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate;4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-Carbocylic acid tert-butyl ester;4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate - [AC80063];1-Piperazinecarboxylic acid, 4-(6-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber: CB81501452
Molecular Formula: C13H19ClN4O2
Formula Weight: 298.77
MOL File: 203519-88-4.mol

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4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 437.3±45.0 °C(Predicted)
Density: 1.253
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.29±0.26(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0143393
Product name: 1-BOC-4-(6-CHLOROPYRIMIDIN-4-YL)PIPERAZINE
Purity: 95.00%
Packaging: 5MG
Price: $502.14
Updated: 2021/12/16

AK Scientific

Product number: 0427AB
Product name: tert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate
Packaging: 10g
Price: $3141
Updated: 2021/12/16

Crysdot

Product number: CD11168948
Product name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylicacidtert-butylester
Purity: 95+%
Packaging: 1g
Price: $576
Updated: 2021/12/16

Crysdot

Product number: CD11168948
Product name: 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylicacidtert-butylester
Purity: 95+%
Packaging: 250mg
Price: $265
Updated: 2021/12/16

Alichem

Product number: 203519884
Product name: tert-Butyl4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate
Packaging: 1g
Price: $366.08
Updated: 2021/12/16

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4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

1193-21-1

57260-71-6

203519-88-4

Step 1: Synthesis of tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate In a microwave reaction tube, 4,6-dichloropyrimidine (0.5 g, 3.36 mmol), N-BOC-piperazine (0.69 g, 3.36 mmol) and triethylamine (0.34 g, 3.36 mmol) were dissolved in acetonitrile (10 mL). The reaction mixture was microwaved at 120 °C for 2 hours. After completion of the reaction, the mixture was diluted with ethyl acetate, washed sequentially with saturated ammonium chloride solution and dried over anhydrous magnesium sulfate. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target compound tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate (0.82 g, 91% yield). 1H NMR (500MHz, CDCl3): δ 8.39 (s, 1H), 6.50 (s, 1H), 3.65 (m, 4H), 3.52 (m, 4H), 1.48 (s, 9H).

References

[1] Patent: WO2012/69852, 2012, A1. Location in patent: Page/Page column 69
[2] Patent: CN106045918, 2016, A. Location in patent: Paragraph 0098; 0099
[3] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 21
[4] Patent: WO2007/56023, 2007, A2. Location in patent: Page/Page column 57
[5] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 36

4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(6-Chloro-pyriMidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 203519-88-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

203519-88-4, 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl esterRelated Search:

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203519-88-4

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