6-Chloro-4-pyrimidinecarboxylic acid
- Product Name
- 6-Chloro-4-pyrimidinecarboxylic acid
- CAS No.
- 37131-91-2
- Chemical Name
- 6-Chloro-4-pyrimidinecarboxylic acid
- Synonyms
- 6-Chlor-pyrimidin-4-carbonsaeure;4-Chloro-6-pyrimidinecarboxylic acid;6-chloropyrimidine-4-carboxylic acid;6-Chloro-4-pyrimidinecarboxylic acid;6-Chloro-pyrimidin-4-carboxylic acid;4-PyriMidinecarboxylic acid, 6-chloro-;6-Chloropyrimidine-4-carboxylic acid 97%;6-Chloro-4-pyrimidinecarboxylic acid ISO 9001：2015 REACH
- CBNumber
- CB81501553
- Molecular Formula
- C5H3ClN2O2
- Formula Weight
- 158.54
- MOL File
- 37131-91-2.mol
6-Chloro-4-pyrimidinecarboxylic acid Property
- Boiling point:
- 343.7±22.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.44±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C5H3ClN2O2/c6-4-1-3(5(9)10)7-2-8-4/h1-2H,(H,9,10)
- InChIKey
- RWSPRTBXAXZIOS-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(C(O)=O)=N1
Safety
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405203
- Product name
- 6-Chloropyrimidine-4-carboxylicAcid
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4H58-5-4N
- Product name
- 6-Chloropyrimidine-4-carboxylic acid
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-W005983
- Product name
- 6-Chloropyrimidine-4-carboxylicacid
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CS-W005983
- Product name
- 6-Chloropyrimidine-4-carboxylicacid
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 073471
- Product name
- 6-Chloro-4-pyrimidinecarboxylic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
6-Chloro-4-pyrimidinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
6299-87-2
37131-91-2
General procedure for the synthesis of 6-chloropyrimidine-4-carboxylic acid from 6-hydroxy-4-pyrimidinecarboxylic acid: 2 g of 6-hydroxy-4-pyrimidinecarboxylic acid was dissolved in 30 mL of ethyl acetate, and oxalyl chloride (3.75 mL, 3 eq., 0.043 mol) was slowly added, followed by the addition of a few drops of N,N-dimethylformamide (gas was observed to escape). The reaction mixture was heated to reflux at 75 °C for 3 h, subsequently cooled to room temperature and allowed to stand overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a black solid product in quantitative yield. The resulting solid was to be stored under nitrogen protection at 4 °C.1H NMR analysis showed the product to be a mixture of 6-chloropyrimidine-4-carboxylic acid and its corresponding chloride derivatives (unstable at room temperature).1H NMR (d6-DMSO) data were as follows: 9.28 (s, 1H), 8.18 (s, 1H) for 6-chloropyrimidine-4-carboxylic acid; 8.45 (s, 1H), 8.45 (s, 1H), 8.93 (s, 1H), 8.45 (s, 1H), 8.45 (s, 1H), 8.45 (s, 1H), 6.93 (s, 1H) and 8.45 (s, 1H). 6.93 (s, 1H) for the signals of the chloride derivatives.
References
[1] Patent: WO2010/20432, 2010, A2. Location in patent: Page/Page column 91-92
6-Chloro-4-pyrimidinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-4-pyrimidinecarboxylic acid manufacturers
- Product
- 6-Chloro-4-pyrimidinecarboxylic acid 37131-91-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-18
- Product
- 6-Chloro-4-pyrimidinecarboxylic acid 37131-91-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-Chloro-4-pyrimidinecarboxylic acid 37131-91-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09