FOSALVUDINE TIDOXIL

Product Name: FOSALVUDINE TIDOXIL
CAS No.: 763903-67-9
Chemical Name: FOSALVUDINE TIDOXIL
Synonyms: HDP990003;HDP-990003;HDP99.0003;HDP 990003;HDP 99.0003;HDP-99.0003;FOSALVUDINE TIDOXIL;JHXLLEDIXXOJQD-WELGVCPWSA-N;5'-Thymidylic acid, 3'-deoxy-3'-fluoro-, mono[2-(decyloxy)-3-(dodecylthio)propyl] ester
CBNumber: CB81509115
Molecular Formula: C35H64FN2O8PS
Formula Weight: 722.93
MOL File: 763903-67-9.mol

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FOSALVUDINE TIDOXIL Property

Density: 1.14±0.1 g/cm3(Predicted)
pka: 1.36±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013909
Product name: FOSALVUDINE TIDOXIL
Purity: 95.00%
Packaging: 5MG
Price: $498.14
Updated: 2021/12/16

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FOSALVUDINE TIDOXIL Chemical Properties,Usage,Production

Uses

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].

in vivo

Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) induces significant mitochondrial hepatotoxicity in rats^[1].

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	15, 40, or 100 mg/kg/day
Administration:	Oral gavage, 8 weeks
Result:	Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively.

References

[1] Venhoff AC, et al. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob Agents Chemother. 2009 Jul;53(7):2748-51. DOI:10.1128/AAC.00364-09

FOSALVUDINE TIDOXIL Preparation Products And Raw materials

Raw materials

Preparation Products

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FOSALVUDINE TIDOXIL Suppliers

China 1 United States 3 Global 4

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
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TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

763903-67-9, FOSALVUDINE TIDOXILRelated Search:

2',3'-DIDEOXY-3'-FLUOROURIDINE 3'-Deoxy-3'-fluorothymidine FOSALVUDINE TIDOXIL

FOSALVUDINE TIDOXIL

JHXLLEDIXXOJQD-WELGVCPWSA-N

HDP 99.0003

HDP 990003

HDP99.0003

HDP-99.0003

HDP990003

HDP-990003

5'-Thymidylic acid, 3'-deoxy-3'-fluoro-, mono[2-(decyloxy)-3-(dodecylthio)propyl] ester

763903-67-9