Ampicillin sodium
Broad-spectrum penicillin Chemical Properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent- Product Name
- Ampicillin sodium
- CAS No.
- 69-52-3
- Chemical Name
- Ampicillin sodium
- Synonyms
- AMPICILLIN SODIUM SALT;penialmen;omnipen-n;pena/n;Alpen-n;Anhypen;Amcill-s;Citteral;Cilleral;Alppen-N
- CBNumber
- CB8151850
- Molecular Formula
- C16H20N3NaO4S
- Formula Weight
- 373.4
- MOL File
- 69-52-3.mol
Ampicillin sodium Property
- Melting point:
- 215 °C (dec.)(lit.)
- alpha
- +246～+272°
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL, clear, very faintly yellow
- form
- powder
- color
- white with slight yellow cast
- PH
- pH(100g/l, 25℃):8.0～10.0
- Water Solubility
- Freely soluble in water. Sparingly soluble in acetone
- BRN
- 4119211
- InChI
- InChI=1/C16H19N3O4S.Na.H/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);;/t9-,10-,11+,14-;;/s3
- InChIKey
- XCZQUQSOMVIRFX-AGYZSTNLNA-N
- SMILES
- C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|
- CAS DataBase Reference
- 69-52-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 42/43-36/37/38-22
- Safety Statements
- 22-36/37-45-36-26
- WGK Germany
- 2
- RTECS
- XH8400000
- F
- 3-10
- HS Code
- 29419000
- Toxicity
- LD50 oral in rat: > 5314mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 95586
- Product name
- XLD Agar
- Purity
- suitable for microbiology, NutriSelect? Basic
- Packaging
- 500G
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 1033203
- Product name
- Ampicillin sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 125mg
- Price
- $358
- Updated
- 2024/03/01
- Product number
- 171255-M
- Product name
- Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem
- Purity
- sterile, suitable for tissue culture
- Packaging
- 20ml
- Price
- $62.2
- Updated
- 2022/05/15
- Product number
- 171254
- Product name
- Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem
- Purity
- Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac
- Packaging
- 5G
- Price
- $82.4
- Updated
- 2022/05/15
- Product number
- 171254
- Product name
- Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem
- Purity
- Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac
- Packaging
- 25g
- Price
- $284
- Updated
- 2022/05/15
Ampicillin sodium Chemical Properties,Usage,Production
Broad-spectrum penicillin
Ampicillin sodium is a broad-spectrum penicillin, its antibacterial spectrum is broader than penicillin , it has antibacterial activity on some gram-negative bacteria (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis) . Its effects on gram-positive cocci are similar to penicillin. Enzymatic hydrolysis of penicillin produced by bacteria may also make it inactive. It is clinically applicable in the treatment of respiratory infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, meningitis, septicemia, endocarditis caused by sensitive bacteria. This product is a drug of choice for enterococcal infections.
The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties
White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste.
Uses
A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other.
production method
It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product.
Category
Toxic substances
Toxicity grading
Low toxic
Acute toxicity
Oral-rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg.
Flammability and hazard characteristics
Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases.
Storage Characteristics
Ventilated, low-temperature ,dry storeroom.
Extinguishing agent
Water, dry powder, foam, sand.
Chemical Properties
White or almost white powder, hygroscopic.
Uses
Penicillin antibacterial.
Uses
Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Uses
diuretic, anti-hypertensive
Definition
ChEBI: Ampicillin sodium is an organic sodium salt. It contains an ampicillin(1-).
brand name
Polycillin-N (Bristol-Myers Squibb).
General Description
Chemical structure: ?-lactam
Biological Activity
ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with ic50 value of 1.8 μg/ml [1].ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].in e. coli 146 cells treated with ether, ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. in e. coli 146 cells, the minimal inhibitory concentration (mic) of ampicillin was 3.1 μg/ml [1]. in e. coli and s. typhi, ampicillin and epicillin at concentrations close to mic values killed bacteria at slower rates than amoxycillin [2].in experimental mouse infections, oral or subcutaneous treatment of ampicillin at the dose of 0.2 ml/20 g was significantly more effective than epicillin and amoxycillin against the majority of infections [2].[1]. moore b a, jevons s, brammer k w. inhibition of transpeptidase activity in escherichia coli by thienamycin. antimicrobial agents and chemotherapy, 1979, 15(6): 831-833.[2]. basker m j, gwynn m n, white a r. comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. chemotherapy, 1979, 25(3): 170-180.
Biochem/physiol Actions
Mode of Action: This is a ?-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ?-lactamase cleaves the ?-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
Contact allergens
Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.
Safety Profile
Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.
storage
+4°C
Ampicillin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ampicillin sodium manufacturers
- Product
- Ampicillin sodium 69-52-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 5KG
- Purity
- 845-988μg/mg; Sterile; USP
- Supply Ability
- 1000KGS
- Release date
- 2021-07-13
- Product
- Ampicillin sodium 69-52-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-08-14
- Product
- Ampicillin sodium 69-52-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-08-14