Larazotide
- Product Name
- Larazotide
- CAS No.
- 258818-34-7
- Chemical Name
- Larazotide
- Synonyms
- AT2347;AT-2347;AT 2347;larazotide;Unii-zn3R5560zv;Gly-Gly-Val-Leu-Val-Gln-Pro-Gly;Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine;Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-
- CBNumber
- CB81518515
- Molecular Formula
- C32H55N9O10
- Formula Weight
- 725.83
- MOL File
- 258818-34-7.mol
Larazotide Property
- Density
- 1.254
- storage temp.
- Store at -20°C
- solubility
- DMSO: Insoluble;Ethanol: Insoluble
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: 25 mg/mL (34.44 mM)
- Sequence
- H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH
Larazotide Chemical Properties,Usage,Production
Uses
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].
Definition
ChEBI: Larazotide is an oligopeptide.
in vivo
Larazotide (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice[1].
| Animal Model: | HLA-HCD4/DQ8 double transgenic mice[2] |
| Dosage: | 250 μg |
| Administration: | Intraperitoneal injection; 250 μg twice a week for 7 weeks |
| Result: | Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels. |
References
[1] Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427. DOI:10.3390/ijms22179427
[2] Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94. DOI:10.1016/j.peptides.2012.02.015
Larazotide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Larazotide manufacturers
- Product
- Larazotide 258818-34-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-17
- Product
- Larazotide 258818-34-7
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-30