6-THIO-2'-DEOXYGUANOSINE
- Product Name
- 6-THIO-2'-DEOXYGUANOSINE
- CAS No.
- 789-61-7
- Chemical Name
- 6-THIO-2'-DEOXYGUANOSINE
- Synonyms
- tgdr;6-SH-dG;NSC-71261;6-Thio-dG;nci-c01581;Aids010571;Aids-010571;Thiodeoxyguanosine;6-Thio-dG (β-TGdR);6-SH-deoxyguanosine
- CBNumber
- CB8152534
- Molecular Formula
- C10H13N5O3S
- Formula Weight
- 283.31
- MOL File
- 789-61-7.mol
6-THIO-2'-DEOXYGUANOSINE Property
- Melting point:
- 190-192 °C
- Boiling point:
- 709.1±70.0 °C(Predicted)
- Density
- 2.02±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), DMF (Slightly), Methanol (Slightly, Heated), Water (Very Slightly)
- form
- Solid
- pka
- 6.81±0.20(Predicted)
- color
- Yellow to Brown
Safety
- Hazardous Substances Data
- 789-61-7(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 19154
- Product name
- 6-thio-2′-Deoxyguanosine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19154
- Product name
- 6-thio-2′-Deoxyguanosine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 19154
- Product name
- 6-thio-2′-Deoxyguanosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 19154
- Product name
- 6-thio-2′-Deoxyguanosine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $290
- Updated
- 2024/03/01
- Product number
- D281650
- Product name
- 2''-Deoxy-6-thioGuanosine
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
6-THIO-2'-DEOXYGUANOSINE Chemical Properties,Usage,Production
Uses
Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
Biological Activity
6-thio-dg is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. it is an anti-cancer inhibitor [1]. cancer cells were very sensitive to 6-thio-dg with observed ic50 values ranging from 0.7-2.9 μm, depending on cell types [3].telomeres are found at the end of eukaryotic linear chromosomes. they are essential for genomic stability and chromosome maintenance [3].in hct116 human colon cancer cell line, treatment with 6-thio-dg made progressive telomere shortening independent of telomerase activity inhibition and induced telomere dysfunction. grn163l is a telomerase inhibitor. in hct116 cells, treatment with grn163l and 6-thio-dg together increased telomere shortening. within 1 week, 6-thio-dg killed most of hct116 cells and altered cellular morphology. normal bj fibroblast cells are telomerase silent. after 1 week, treatment with 6-thio-dg showed no effect on cell morphology. after long-term treatment with 6-thio-dg, no effect on telomere shortening was found [1].in murine mode with xenograft derived from a549 lung cancer cell line, as compared to controls, intraperitoneal injection with 2 mg/kg of 6-thio-dg every other day completely prevented progressive tumor growth. ki67 is a biomarker correlating with proliferation levels. compared to controls, 6-thio-dg decreased ki67 staining. treatment with 6-thio-dg through local injection resulted in even more dramatic decrease in the tumor growth rate compared to untreated controls [3].
References
[1]. mender i, gryaznov s, dikmen zg, et al. abstract lb-125: a novel telomerase inhibitor. cancer research, 2013, 73(8 supplement): lb-125-lb-125.
[2]. mender i, gryaznov s, shay jw. a novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells. oncoscience, 2015, 2(8): 693.
[3]. mender i, gryaznov s, dikmen zg, et al. induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2-deoxyguanosine. cancer discovery, 2015, 5(1): 82-95.
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