(2-Trifluoromethyl-pyridin-3-yl)-methanol
- Product Name
- (2-Trifluoromethyl-pyridin-3-yl)-methanol
- CAS No.
- 131747-57-4
- Chemical Name
- (2-Trifluoromethyl-pyridin-3-yl)-methanol
- Synonyms
- 2-(Trifluoromethyl)pyridine-3-methanol;2-(Trifluoromethyl)-3-pyridinemethanol;2-(trifluoromethyl)-3-pyridyl]methanol;3-pyridineMethanol, 2-(trifluoroMethyl)-;(2-Trifluoromethyl-pyridin-3-yl)-methanol;(2-trifluoromethyl pyridine-3-yl) -methanol
- CBNumber
- CB81553840
- Molecular Formula
- C7H6F3NO
- Formula Weight
- 177.12
- MOL File
- 131747-57-4.mol
(2-Trifluoromethyl-pyridin-3-yl)-methanol Property
- Boiling point:
- 209℃
- Density
- 1.362
- Flash point:
- 80℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.08±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T791160
- Product name
- (2-(Trifluoromethyl)pyridin-3-yl)methanol
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- T11120
- Product name
- 2-(Trifluoromethyl)-3-pyridinemethanol
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- PC905183
- Product name
- (2-(Trifluoromethyl)pyridin-3-yl)methanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- T11120
- Product name
- 2-(Trifluoromethyl)-3-pyridinemethanol
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- AS147669
- Product name
- (2-(Trifluoromethyl)pyridin-3-yl)methanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
(2-Trifluoromethyl-pyridin-3-yl)-methanol Chemical Properties,Usage,Production
Synthesis
208517-35-5
131747-57-4
General procedure for the synthesis of (2-trifluoromethyl-pyridin-3-yl)-methanol from ethyl 2-trifluoromethylnicotinate: sodium borohydride (0.35 g, 9.1 mmol) was suspended in anhydrous tetrahydrofuran (20 mL). Anhydrous tetrahydrofuran solution (20 mL) of ethyl 2-trifluoromethylnicotinate (1.00 g, 0.46 mmol) was added dropwise to the stirred suspension under ice bath cooling. The reaction mixture was stirred at 4°C for 16 hours. Upon completion of the reaction, methanol (5 mL) was added to quench the residual sodium borohydride, followed by the addition of 15% aqueous sodium hydroxide solution (25 mL). The resulting mixture was continued to be stirred at 25 °C for 30 min, followed by removal of tetrahydrofuran and methanol by rotary evaporation. The remaining aqueous phase was extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated by rotary evaporation to afford the target product (2-trifluoromethyl-pyridin-3-yl)-methanol as a yellow oil (0.61 g, 75% yield), which could be used in subsequent reactions without further purification. The product was characterized by 1H-NMR (CDCl3): δ 8.64 (d, J = 4.5 Hz, 1H), 8.17 (d, J = 8.0 Hz, 1H), 7.57 (dd, J = 8.0, 4.5 Hz, 1H), 4.98 (s, 2H), 1.99 (s, 1H). Mass spectrum (ESI+): m/z (M + H)+ = 178.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5352 - 5359
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Synthesis, 2005, # 16, p. 2751 - 2757
[4] Patent: WO2015/187934, 2015, A1. Location in patent: Paragraph 0228
(2-Trifluoromethyl-pyridin-3-yl)-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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