Vanillyl butyl ether

ChemicalBook > CAS DataBase List > Vanillyl butyl ether

Vanillyl butyl ether

Description

Product Name: Vanillyl butyl ether
CAS No.: 82654-98-6
Chemical Name: Vanillyl butyl ether
Synonyms: 4-(Butoxymethyl)-2-methoxyphenol;FEMA 3796;Vanillyl Butyl;4-(Butoxymethyl);Vanillyl butyl eth;BUTYL VANILLY ETHER;Vanilly butyl ether;VANILLYL BUTYL ETHER;BUTYL VANILLYL ETHER;Vanillin butyl ether
CBNumber: CB8156299
Molecular Formula: C12H18O3
Formula Weight: 210.27
MOL File: 82654-98-6.mol

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Vanillyl butyl ether Property

Boiling point:: 241 °C(lit.)
Density: 1.057 g/mL at 25 °C(lit.)
vapor pressure: 0.42-2000Pa at 20-25℃
refractive index: n20/D 1.516(lit.)
FEMA: 3796 | VANILLYL BUTYL ETHER
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: soluble (Insoluble in water. Soluble in organic solvents, oils.)
form: Oil
color: Colourless
Specific Gravity: 1.057
Odor: at 100.00 %. vanilla fruity
Odor Type: vanilla
Water Solubility: 1.79-1690mg/L at 20℃
JECFA Number: 888
InChIKey: VLDFMKOUUQYFGF-UHFFFAOYSA-N
LogP: 2.2-2.4 at 23-25℃
EPA Substance Registry System: Phenol, 4-(butoxymethyl)-2-methoxy- (82654-98-6)

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Safety

WGK Germany: 3
HS Code: 2909.50.4050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W379601
Product name: Vanillyl butyl ether
Purity: natural (US), 97%, FG
Packaging: sample-k
Price: $59.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: W379601
Product name: Vanillyl butyl ether
Purity: natural (US), 97%, FG
Packaging: 100g
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: W379601
Product name: Vanillyl butyl ether
Purity: natural (US), 97%, FG
Packaging: 500g
Price: $759
Updated: 2024/03/01

Sigma-Aldrich

Product number: W379601
Product name: Vanillyl butyl ether
Purity: natural (US), 97%, FG
Packaging: 1kg
Price: $1280
Updated: 2024/03/01

TCI Chemical

Product number: V0161
Product name: Vanillyl Butyl Ether
Packaging: 5G
Price: $28
Updated: 2024/03/01

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Vanillyl butyl ether Chemical Properties,Usage,Production

Description

Vanillyl butyl ether(82654-98-6) is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products. It has a characteristic trigeminal, burning, hot pepper nature and can be used in spice flavors like pepper, cinnamon and ginger, as well as blends for some baked applications, including cookies. It has some other applications include flavoring for alcoholic and non-alcoholic beverages with herbal, berry, vanilla, cola, ginger ale, root beer, hot chocolate, chai, ice tea and mints. It can also be used as a warming agent.

Description

Vanillyl butyl ether is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent.

Chemical Properties

Vanillyl butyl ether has a weak, vanillic, acidic odor.

Uses

Vanillyl butyl ether is a compound hypothesized to have warming and vasodilation mechanisms when applied on the skin as a cream.

General Description

Vanillyl butyl ether is an alkoxy-substituted benzyl derivative mainly used as a flavoring agent.

Biochem/physiol Actions

Taste at 10-15%

Side effects

Vanilloids contain vanillyl groups that bind to the transient receptor potential type V1 channel (Vanilloid receptor-1, TRPV1) that respond to noxious stimuli such as high temperatures and acidic pH. This causes neurons to release glutamate, adenosine triphosphate (ATP) and a variety of neuropeptides, resulting in the warming sensation. Vanillyl butyl ether causes serious eye irritation and may cause an allergic skin reaction.

Safety

Vanillyl butyl ether (VBE) is a weak skin sensitizer, which is a substance whose chemical structure indicates that it is expected to react with skin proteins, with a NESIL value of 3500 μg/cm2. VBE is not genotoxic, phototoxic or photosensitizing. In addition, VBE is not persistent, bioaccumulative and toxic (PBT) according to IFRA environmental criteria, and its risk quotient is less than 1 based on its current use in Europe and North America (i.e. PEC/PNEC). The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class III materials, and exposure to VBE was below the TTC (0.47 mg/day)^[1].

Synthesis

At present, the synthesis of vanillyl butyl ether is mainly obtained by dehydrating and condensing vanillyl alcohol and n-butyl alcohol under an acid catalyst. However, the yield of the method is low mainly because water generated by the reaction can inhibit the etherification reaction. The common acid catalyst such as AlCl is used3、FeCl3It is easy to hydrolyze in the presence of water and lose its catalytic action. A new synthesis method comprises the following steps: dissolving vanillin in a solvent, adding a metal complex hydride and an alkylating reagent after uniformly stirring, reacting for 3-4 hours at 30-40 ℃ to obtain a vanillin alcohol ether solution, and separating and purifying the vanillin alcohol ether solution to obtain vanillin alcohol ether.

References

[1] A.M. API . RIFM fragrance ingredient safety assessment, vanillyl butyl ether, CAS Registry Number 82654-98-6[J]. Food and Chemical Toxicology, 2021, 153: Article 112361. DOI:10.1016/j.fct.2021.112361.

Vanillyl butyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vanillyl butyl ether manufacturers

Hebei Longbang Technology Co., Ltd

Product: Vanillyl butyl ether 82654-98-6
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-30

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Vanillin butyl ether 82654-98-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-05-10

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Vanillyl butyl ether 82654-98-6
Price: US $99.00-66.00/kg
Min. Order: 0.001kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-09

82654-98-6, Vanillyl butyl etherRelated Search:

Buprofezin p-Cresol 2-Butoxyethanol 3-Trifluoromethylphenol C8E3 Butyl acetate p-(2-Methoxyethyl) phenol Butylated hydroxyanisole tert-Butyl methyl ether Tetraethyleneglycol monododecyl ether 3-BENZYLOXYBENZYL ALCOHOL Xylenol N-BUTYL METHYL ETHER o-Cresol Diethylene glycol monobutyl ether ANTIFOAM PE-L Guaiacol Ethylbenzene

VANILLYL BUTYL ETHER

4-BUTOXY-2-METHOXYPHENOL

BUTYL VANILLYL ETHER

FEMA 3796

VANILLYL BUTYLETHER 96+%

Phenol, 4-(butoxymethyl)-2-methoxy-

2-Methoxy-4-(butoxymethyl)phenol

4-(Butoxymethyl)-2-methoxyphenol

4-Butoxymethyl-2-methoxyphenol

Vanillyl butyl eth

4-(Butoxymethyl)

BUTYL VANILLY ETHER

Slimauty Vbe (Vanillyl Butyl Ether)

Vanillyl Butyl Ether (VBE) 98%

Vanillyl Butyl Ether VBE 82654-98-6 kf-wang(at)kf-chem.com

Vanillyl Butyl

Tetrabutylammonium nitrate 1941-27-1

Vanillin butyl ether

Vanilly butyl ether

82654-98-6

4HOC6H33OCH3CH2OCH23CH3

API intermediates

Alphabetical Listings

Flavors and Fragrances

Q-Z

Synthetic Fragrance

82654-98-6