2-Iodo-3-methoxyaniline
- Product Name
- 2-Iodo-3-methoxyaniline
- CAS No.
- 98991-09-4
- Chemical Name
- 2-Iodo-3-methoxyaniline
- Synonyms
- 3-Amino-2-iodoanisole;2-Iodo-3-methoxyaniline;2-Iodo-3-methoxy-phenylamine;Benzenamine, 2-iodo-3-methoxy-;3-AMino-2-iodoanisole[2-Iodo-3-Methoxyaniline]
- CBNumber
- CB81568792
- Molecular Formula
- C7H8INO
- Formula Weight
- 249.05
- MOL File
- 98991-09-4.mol
2-Iodo-3-methoxyaniline Property
- Boiling point:
- 300.9±32.0 °C(Predicted)
- Density
- 1.807±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 2.11±0.10(Predicted)
- Appearance
- Off-white to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7402CU
- Product name
- 2-Iodo-3-methoxyaniline
- Packaging
- 1g
- Price
- $276
- Updated
- 2021/12/16
- Product number
- HCH0044910
- Product name
- 2-IODO-3-METHOXYBENZENAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.26
- Updated
- 2021/12/16
- Product number
- A185153
- Product name
- 2-Iodo-3-methoxyaniline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A185153
- Product name
- 2-Iodo-3-methoxyaniline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- A185153
- Product name
- 2-Iodo-3-methoxyaniline
- Purity
- 95%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
2-Iodo-3-methoxyaniline Chemical Properties,Usage,Production
Synthesis
194869-14-2
98991-09-4
The general procedure for the synthesis of 2-iodo-3-methoxyaniline from the compound (CAS:194869-14-2) was as follows: trifluoroacetic acid (20 mL) was slowly added dropwise to a solution of compound 11 (5 g, 14.3 mmol) in dichloromethane (60 mL) at 0 °C. The reaction mixture was gradually warmed up to room temperature and stirred for 2 h under light protection. Upon completion of the reaction, the reaction solution was concentrated by rotary evaporator and diluted with ethyl acetate (150 mL). The pH was adjusted to 7~8 by slowly adding saturated aqueous NaHCO3 solution through a dropping funnel at 0 °C. The aqueous layer was extracted with ethyl acetate (80 mL × 2). The organic phases were combined, washed with saturated aqueous NaCl (150 mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 10:1) to afford 2-iodo-3-methoxyaniline (3.2 g, 90% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.07 (t, J = 8.0 Hz, 1H), 6.42-6.40 (m, 1H), 6.24-6.21 (m, 1H), 4.22 (br, 2H), 3.85 (s, 3H).13C NMR (100 MHz, CDCl3) δ 158.9, 148.4, 129.5, 107.8, 100.7, 76.0, 56.3. mass spectra (ESI, m/z) measured value 250.0 ([M + H]+).
References
[1] Synlett, 2005, # 16, p. 2469 - 2472
[2] Tetrahedron Letters, 2011, vol. 52, # 19, p. 2488 - 2491
2-Iodo-3-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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