BOC-TOTA

Product Name: BOC-TOTA
CAS No.: 194920-62-2
Chemical Name: BOC-TOTA
Synonyms: BOC-TOTA;CAS_194920-62-2;BOC-AMINO-PEG3-AMINE;N-Boc-C1-PEG3-C3-NH2;t-boc-N-amido-dPEG??-amine;t-BocNHCH2-PEG3-CH2CH2CH2NH2;t-boc-N-amido-dPEG??-amine (QBD-10225);N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE;BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE;N-Boc-4,7,10-trioxa-1,13-tridecanediamine
CBNumber: CB8159917
Molecular Formula: C15H32N2O5
Formula Weight: 320.42
MOL File: 194920-62-2.mol

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BOC-TOTA Property

Boiling point:: 432.4±35.0 °C(Predicted)
Density: 1.035 g/mL at 20 °C
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Oil
pka: 12.66±0.46(Predicted)
color: Colourless

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Safety

WGK Germany: 3
F: 10-34
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 93113
Product name: N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Purity: ≥95.0% (NT)
Packaging: 1G
Price: $199
Updated: 2025/07/31

TCI Chemical

Product number: B6622
Product name: N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Packaging: 1G
Price: $96
Updated: 2025/07/31

TRC

Product number: T117535
Product name: tert-Butyl(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate
Packaging: 1g
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: AMTGC275
Product name: N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Packaging: 250mg
Price: $27
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50423
Product name: Boc-1-amino-4,7,10-trioxa-13-tridecanamine
Packaging: 250mg
Price: $50
Updated: 2021/12/16

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BOC-TOTA Chemical Properties,Usage,Production

Description

Boc-TOTA is a linker containing an amino group with a Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.

Uses

Protected linker.

reaction suitability

reagent type: cross-linking reagent

Synthesis

4246-51-9

24424-99-5

194920-62-2

GENERAL STEPS: A solution of di-tert-butyl dicarbonate (1.99 g, 9.12 mmol) in dichloromethane (55 mL + 5 mL of rinse solution) was slowly added dropwise through the addition funnel to a solution of 4,7,10-trioxo-1,13-tridecanediamine (20 mL, 91.2 mmol) in dichloromethane (100 mL) at 0°C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL). The organic and aqueous phases were separated, and the organic phase was washed sequentially with deionized water (3×50 mL) and saturated saline (50 mL), dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to afford N-BOC-4,7,10-trioxa-1,13-tridecanediamine (2.571 g, 88% yield) as a colorless liquid. Thin layer chromatography (TLC) analysis: Rf = 0.14 (Expanding agent: 10% methanol, 0.5% ammonia in dichloromethane solution).1H-NMR (CDCl3, 400 MHz) data: δ 5.10 (broad single peak, 1H), 3.51-3.64 (multiple peaks, 12H), 3.61 (single peak, 4H), 3.21 (multiple peaks, 2H), 2.79 (triple peak, J = 6.7 Hz, 1H), 1.77-1.68 (multiple peaks, 4H), 1.42 (single peak, 9H) ppm.

IC 50

PEGs

References

[1] Chemical Communications, 2010, vol. 46, # 39, p. 7403 - 7405
[2] Bioconjugate Chemistry, 2013, vol. 24, # 12, p. 2058 - 2066
[3] Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2663 - 2664
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 11, p. 1798 - 1802
[5] European Journal of Organic Chemistry, 2004, # 9, p. 1983 - 2001

BOC-TOTA Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-TOTA Suppliers

China 96 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 12 Global 113

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 497
Advantage: 58

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

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View Lastest Price from BOC-TOTA manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate 194920-62-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

194920-62-2, BOC-TOTARelated Search:

Methyl sorbate Octa(OtBu)-Glu-OtBu tert-butyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate Tert-butyl N-(5-hydroxy-2,2-dimethylpentyl)carbamate Carbamic acid, (4-bromo-5-fluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(5-hydroxy-4,4-dimethylpentyl)-, 1,1-dimethylethyl ester tert-butyl N-({5H,6H,7H,8H-imidazo[1,2-a]pyrimidin-2-yl}met hyl)carbamate TERT-BUTYL (5-CYANO-2,3-DIHYDRO-1H-INDEN-1-YL)CARBAMATE BOC-TOTA 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE 17-Oxo-6,9,12-trioxa-2,16-diazaeicosanedioic acid 1-(1,1-dimethylethyl)ester

1-(T-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE

1-(TERT-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE

3-[2-(2-(3-(BOC-AMINO)PROPYLOXY)ETHOXY)ETHOXY]PROPYLAMINE

BOC-TOTA

BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE

N-Boc-4,7,10-trioxa-1,13-tridecanediamine >=95.0% (NT)

tert-butyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate

tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy) 194920-62-2

N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

tert-Butyl (3-(2-(2-(3-aMinopropoxy)ethoxy)ethoxy)propyl)carbaMate

CAS_194920-62-2

t-BocNHCH2-PEG3-CH2CH2CH2NH2

BOC-AMINO-PEG3-AMINE

6,9,12-Trioxa-2-azapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester

t-boc-N-amido-dPEG??-amine

N-Boc-C1-PEG3-C3-NH2

<i>N</i>-Boc-4,7,10-trioxa-1,13-tridecanediamine

t-boc-N-amido-dPEG??-amine (QBD-10225)

194920-62-2

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