ChemicalBook > CAS DataBase List > BOC-TOTA

BOC-TOTA

Product Name
BOC-TOTA
CAS No.
194920-62-2
Chemical Name
BOC-TOTA
Synonyms
BOC-TOTA;CAS_194920-62-2;BOC-AMINO-PEG3-AMINE;N-Boc-C1-PEG3-C3-NH2;t-boc-N-amido-dPEG??-amine;t-BocNHCH2-PEG3-CH2CH2CH2NH2;t-boc-N-amido-dPEG??-amine (QBD-10225);N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE;BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE;N-Boc-4,7,10-trioxa-1,13-tridecanediamine
CBNumber
CB8159917
Molecular Formula
C15H32N2O5
Formula Weight
320.42
MOL File
194920-62-2.mol
More
Less

BOC-TOTA Property

Boiling point:
432.4±35.0 °C(Predicted)
Density 
1.035 g/mL at 20 °C
storage temp. 
2-8°C
solubility 
Chloroform, Ethyl Acetate (Slightly)
form 
Oil
pka
12.66±0.46(Predicted)
color 
Colourless
More
Less

Safety

WGK Germany 
3
F 
10-34
HS Code 
2924190090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93113
Product name
N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Purity
≥95.0% (NT)
Packaging
1G
Price
$199
Updated
2025/07/31
TCI Chemical
Product number
B6622
Product name
N-Boc-4,7,10-trioxa-1,13-tridecanediamine
Packaging
1G
Price
$96
Updated
2025/07/31
TRC
Product number
T117535
Product name
tert-Butyl(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate
Packaging
1g
Price
$115
Updated
2021/12/16
Iris Biotech GmbH
Product number
BNN1028
Product name
Boc-TOTA
Packaging
1g
Price
$135
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50423
Product name
Boc-1-amino-4,7,10-trioxa-13-tridecanamine
Packaging
1g
Price
$150
Updated
2021/12/16
More
Less

BOC-TOTA Chemical Properties,Usage,Production

Description

Boc-TOTA is a linker containing an amino group with a Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.

Uses

Protected linker.

reaction suitability

reagent type: cross-linking reagent

Synthesis

4246-51-9

24424-99-5

194920-62-2

GENERAL STEPS: A solution of di-tert-butyl dicarbonate (1.99 g, 9.12 mmol) in dichloromethane (55 mL + 5 mL of rinse solution) was slowly added dropwise through the addition funnel to a solution of 4,7,10-trioxo-1,13-tridecanediamine (20 mL, 91.2 mmol) in dichloromethane (100 mL) at 0°C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL). The organic and aqueous phases were separated, and the organic phase was washed sequentially with deionized water (3×50 mL) and saturated saline (50 mL), dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to afford N-BOC-4,7,10-trioxa-1,13-tridecanediamine (2.571 g, 88% yield) as a colorless liquid. Thin layer chromatography (TLC) analysis: Rf = 0.14 (Expanding agent: 10% methanol, 0.5% ammonia in dichloromethane solution).1H-NMR (CDCl3, 400 MHz) data: δ 5.10 (broad single peak, 1H), 3.51-3.64 (multiple peaks, 12H), 3.61 (single peak, 4H), 3.21 (multiple peaks, 2H), 2.79 (triple peak, J = 6.7 Hz, 1H), 1.77-1.68 (multiple peaks, 4H), 1.42 (single peak, 9H) ppm.

IC 50

PEGs

References

[1] Chemical Communications, 2010, vol. 46, # 39, p. 7403 - 7405
[2] Bioconjugate Chemistry, 2013, vol. 24, # 12, p. 2058 - 2066
[3] Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2663 - 2664
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 11, p. 1798 - 1802
[5] European Journal of Organic Chemistry, 2004, # 9, p. 1983 - 2001

BOC-TOTA Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BOC-TOTA Suppliers

China 96 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 12 Global 113
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Chengdu Pukang Biotechnology Co., Ltd
Tel
+86-028-82550498 +86-19102685862
Fax
086-28-82550468
Email
sales@pu-kang.com
Country
China
ProdList
497
Advantage
58
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2150
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Borenpharm Co., Ltd
Tel
027-65563561
Fax
86-27-59218822
Email
sales@borenpharm.com
Country
China
ProdList
1245
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Suzhou JingTong Pharmaceutical Co., Ltd.
Tel
13675155016
Fax
18912765016
Email
tongtf110@sina.com
Country
China
ProdList
963
Advantage
55
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10110
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9984
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Moss Medicine Technology Co., Ltd.
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1959
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
Wuhan Borenpharm Co., Ltd
Tel
027-65563561 18717150066
Fax
027-59218822
Email
3207347307@qq.com
Country
CHINA
ProdList
1238
Advantage
58
Shanghai Pleikon Chemical Technology Co., Ltd
Tel
021-021-54321516 17717324060
Email
2719672468@qq.com
Country
China
ProdList
1880
Advantage
58
Nanjing xiangrui technology co. LTD
Tel
021-021-00000000 15715199582
Email
njrich168@163.com
Country
China
ProdList
549
Advantage
58
Shanghai Jiange Chemical Co., Ltd.
Tel
15921040873
Email
1434142450@qq.com
Country
CHINA
ProdList
7649
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766 13636419861
Email
2258830676@qq.com
Country
China
ProdList
5044
Advantage
58
Xiamen Sinopeg Biotech Co., Ltd.
Tel
400-9189898 17359873007
Email
sales@sinopeg.com
Country
China
ProdList
530
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2373
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7587
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Shanghai Sunmonth Technology Co., LTD
Tel
15216675652
Email
xuanyuelj@163.com
Country
China
ProdList
2864
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
10784
Advantage
58
Shandong Territorial sea Biological Technology Co., LTD
Tel
15092083467
Email
18660263263@163.com
Country
China
ProdList
2810
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7986
Advantage
58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd
Tel
2383948258 19172820304
Email
2383948258@qq.com
Country
China
ProdList
12987
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7938
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Ningbo Chemrio Chemtech Co,.Ltd.
Tel
0574-27891269 18667892864
Email
frank.xiaodong@chemriotech.com
Country
China
ProdList
3883
Advantage
58
More
Less

View Lastest Price from BOC-TOTA manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.
Product
tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate 194920-62-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-12

194920-62-2, BOC-TOTARelated Search:

Methyl sorbate Octa(OtBu)-Glu-OtBu tert-butyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate Tert-butyl N-(5-hydroxy-2,2-dimethylpentyl)carbamate Carbamic acid, (4-bromo-5-fluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(5-hydroxy-4,4-dimethylpentyl)-, 1,1-dimethylethyl ester tert-butyl N-({5H,6H,7H,8H-imidazo[1,2-a]pyrimidin-2-yl}met hyl)carbamate TERT-BUTYL (5-CYANO-2,3-DIHYDRO-1H-INDEN-1-YL)CARBAMATE BOC-TOTA 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE 17-Oxo-6,9,12-trioxa-2,16-diazaeicosanedioic acid 1-(1,1-dimethylethyl)ester

  • 1-(T-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE
  • 1-(TERT-BUTYLOXYCARBONYL-AMINO)-4,7,10-TRIOXA-13-TRIDECANAMINE
  • 3-[2-(2-(3-(BOC-AMINO)PROPYLOXY)ETHOXY)ETHOXY]PROPYLAMINE
  • BOC-TOTA
  • BOC-1-AMINO-4,7,10-TRIOXA-13-TRIDECANAMINE
  • N-Boc-4,7,10-trioxa-1,13-tridecanediamine >=95.0% (NT)
  • tert-butyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate
  • tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy) 194920-62-2
  • N-BOC-4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
  • tert-Butyl (3-(2-(2-(3-aMinopropoxy)ethoxy)ethoxy)propyl)carbaMate
  • CAS_194920-62-2
  • t-BocNHCH2-PEG3-CH2CH2CH2NH2
  • BOC-AMINO-PEG3-AMINE
  • 6,9,12-Trioxa-2-azapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester
  • t-boc-N-amido-dPEG??-amine
  • N-Boc-C1-PEG3-C3-NH2
  • <i>N</i>-Boc-4,7,10-trioxa-1,13-tridecanediamine
  • t-boc-N-amido-dPEG??-amine (QBD-10225)
  • 194920-62-2
  • peg