ChemicalBook > CAS DataBase List > 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE

2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE

Product Name
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE
CAS No.
945-43-7
Chemical Name
2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE
Synonyms
DMPH4;6,7-DIMETHYL-5,6,7,8-TETRAHYDRO-PTERINE MONOHYDROC;6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIN HYDROCHLORIDE;6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride;6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERINE MONOHYDROCHLORIDE;2-AMINO-4-HYDROXY-6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIDINE;2-amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine;6,7-DiMethyl-5,6,7,8-tetrahydropterine hydrochloride >=95%;2-Amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridineHCl;2-amino-6,7-dimethyl-5,6,7,8-tetrahydropteridin-4-ol hydrochloride
CBNumber
CB8160795
Molecular Formula
C8H14ClN5O
Formula Weight
231.68
MOL File
945-43-7.mol
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2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE Property

Melting point:
244-247 °C (dec.)(lit.)
storage temp. 
-20°C
solubility 
PBS (pH 7.2): 1 mg/ml
form 
White powder.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-41-37/38
Safety Statements 
26-36-36/37/39-39
WGK Germany 
-
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D0387
Product name
6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride
Purity
≥95%
Packaging
100mg
Price
$132
Updated
2025/07/31
Cayman Chemical
Product number
21050
Product name
6,7-dimethyl-5,6,7,8-Tetrahydropterin (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$18
Updated
2024/03/01
Cayman Chemical
Product number
21050
Product name
6,7-dimethyl-5,6,7,8-Tetrahydropterin (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
21050
Product name
6,7-dimethyl-5,6,7,8-Tetrahydropterin (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21050
Product name
6,7-dimethyl-5,6,7,8-Tetrahydropterin (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$144
Updated
2024/03/01
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2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

6, 7-dimethyl-5,6,7, 8-Tetrahydropterin hydrochloride is a synthetic analogue of tetrahydro-L-bioterin and is used as a cofactor required for the NOS isoforms, phenylalanine, tyrosine and tryptophan hydroxylases, and other enzymes[1][2].

Biochem/physiol Actions

Synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4).

References

[1] Mayer B, et al. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide. Naunyn Schmiedebergs Arch Pharmacol. 1995 May;351(5):453-63. DOI:10.1007/BF00171035
[2] Suckling CJ, et al. 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1563-6. DOI:10.1016/j.bmcl.2008.01.079

2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

2,3-Butanedione Sodium sulfite Hydrochloric acid Sodium hydroxide 2,5,6-Triaminopyrimidin-4-ol sulphate Carbon Sodium carbonate

Preparation Products

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2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE Suppliers

China 29 Germany 1 Switzerland 2 United Kingdom 1 United States 8 Global 41
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Switzerland
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Alexis Corporation
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Email
alexis-ch@alexis-corp.ch
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945-43-7, 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDERelated Search:

2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE Cyclohexane Dimethanol Dimethylacrylate Allyl methyl carbonate 2-Hydroxyethyl methacrylate

  • 2-amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine
  • 6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERINE MONOHYDROCHLORIDE
  • 6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIN HYDROCHLORIDE
  • 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE
  • 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE HYDROCHLORIDE
  • 2-AMINO-4-HYDROXY-6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIDINE HYDROCHLORIDE
  • 2-AMINO-4-HYDROXY-6,7-DIMETHYL-5,6,7,8-TETRAHYDROPTERIDINE
  • 2-amino-6,7-dimethyl-5,6,7,8-tetrahydropteridin-4-ol hydrochloride
  • 6,7-DIMETHYL-5,6,7,8-TETRAHYDRO-PTERINE MONOHYDROC
  • 2-Amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridineHCl
  • 6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride
  • 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4
  • 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4, 2-Amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinol hydrochloride
  • 2-Amino-6,7-dimethyl-5,6,7,8-tetrahydropteridine-4-ol·hydrochloride
  • 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine hydrochloride,96%
  • DMPH4
  • 6,7-DiMethyl-5,6,7,8-tetrahydropterine hydrochloride >=95%
  • 2-Amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinol hydrochloride
  • 2-Amino-6,7-dimethyl-5,6,7,8-tetrahydropteridin-4(1H)-one hydrochloride
  • 945-43-7
  • C8H14ClN5O
  • C8H13N5O2ClH
  • C8H13N5OHCl
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  • Quinazolines
  • Heterocyclic Building Blocks
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  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Quinazolines