4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE

Product Name: 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
CAS No.: 135721-98-1
Chemical Name: 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
Synonyms: S14506HCl;S 14506 HYDROCHLORIDE;1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride;4-Fluoro-N-(2-(4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl)ethyl)benzaMide hydrochloride;4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
CBNumber: CB8161035
Molecular Formula: C24H27ClFN3O2
Formula Weight: 443.94
MOL File: 135721-98-1.mol

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4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Property

storage temp.: Desiccate at RT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1771
Product name: S14506hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $164
Updated: 2021/12/16

Tocris

Product number: 1771
Product name: S14506hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $648
Updated: 2021/12/16

TRC

Product number: S080863
Product name: S14506
Packaging: 10mg
Price: $155
Updated: 2021/12/16

Usbiological

Product number: 256547
Product name: S 14506 hydrochloride
Packaging: 10mg
Price: $466
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008837
Product name: 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $1291.58
Updated: 2021/12/16

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4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

S 14506 is a full, highly potent and selective SR-1A agonist.

Definition

ChEBI: 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride is a hydrochloride salt that is obtained by reaction of 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. It has a role as a serotonergic agonist and an anxiolytic drug. It contains a 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+).

Biological Activity

Highly potent selective 5-HT 1A receptor full agonist (pK i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 2 and 5-HT 3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo .

4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Suppliers

China 11 Germany 1 South Korea 1 United Kingdom 2 United States 6 Global 21

3B Pharmachem (Wuhan) International Co.,Ltd.

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135721-98-1, 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDERelated Search:

1-Amino-7-naphthol 8-PIPERAZIN-1-YL-NAPHTHALEN-2-OL 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE N,N-DIETHYL-1-NAPHTHYLAMINE 4-FLUORO-N-(2-[4-(7-METHOXY-NAPHTHALEN-1-YL)-PIPERAZIN-1-YL]-ETHYL)-BENZAMIDE 7-METHOXYNAPHTHALEN-1-AMINE 4-FLUORO-N-(2-[4-(7-HYDROXY-NAPHTHALEN-1-YL)-PIPERAZIN-1-YL]-ETHYL)-BENZAMIDE 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE

4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE

S 14506 HYDROCHLORIDE

S14506HCl

1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride

4-Fluoro-N-(2-(4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl)ethyl)benzaMide hydrochloride

135721-98-1

C24H27ClFN3O2

C24H26FN3O2HCl