ChemicalBook > CAS DataBase List > FMOC-GAMMA-ABU-OH

FMOC-GAMMA-ABU-OH

Product Name: FMOC-GAMMA-ABU-OH
CAS No.: 116821-47-7
Chemical Name: FMOC-GAMMA-ABU-OH
Synonyms: FMOC-GABA;FMOC-GABA-OH;FMOC-4-ABU-OH;Fmoc-Gamma-OH;Fmoc-γ-Abu-OH;FMOC-ABU(4)-OH;FMOC-GAMMA-ABU-OH;RARECHEM EM WB 0021;FMOC-NH-(CH2)3-COOH;FMOC-GAMMA-ABU-OH 1 G
CBNumber: CB8165033
Molecular Formula: C19H19NO4
Formula Weight: 325.36
MOL File: 116821-47-7.mol

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FMOC-GAMMA-ABU-OH Property

Melting point:: 172.0 to 176.0 °C
Boiling point:: 571.9±33.0 °C(Predicted)
Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.68±0.10(Predicted)
form: Powder
color: White
Water Solubility: Slightly soluble in water.
BRN: 7491485
InChI: InChI=1S/C19H19NO4/c21-18(22)10-5-11-20-19(23)24-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17H,5,10-12H2,(H,20,23)(H,21,22)
InChIKey: ACUIFAAXWDLLTR-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 116821-47-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52043
Product name: Fmoc-γ-Abu-OH
Purity: Novabiochem?
Packaging: 1g
Price: $19.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52043
Product name: Fmoc-γ-Abu-OH
Purity: Novabiochem?
Packaging: 5G
Price: $172
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52043
Product name: Fmoc-γ-Abu-OH
Purity: Novabiochem?
Packaging: 25g
Price: $679
Updated: 2025/07/31

Sigma-Aldrich

Product number: 04069
Product name: Fmoc-GABA-OH
Purity: ≥97.0% (HPLC)
Packaging: 1g
Price: $90.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 04069
Product name: Fmoc-GABA-OH
Purity: ≥97.0% (HPLC)
Packaging: 5g
Price: $175
Updated: 2025/07/31

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FMOC-GAMMA-ABU-OH Chemical Properties,Usage,Production

Description

Fmoc-4-aminobutanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-4-aminobutanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White powder

Uses

4-(Fmoc-amino)butyric acid is used in agrochemical, pharmaceutical and dyestuff field.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

82911-69-1

56-12-2

116821-47-7

At room temperature, γ-aminobutyric acid (2.00 g, 19.4 mmol) was dissolved in 14 mL of 10% NaHCO3 aqueous solution. Subsequently, a solution of 9-fluorenylmethyl-N-succinimidyl carbonate (4 g, 11.7 mmol) in acetonitrile (40 mL) was slowly added dropwise over a period of 2 hours. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1 hour. After completion of the reaction, the acetonitrile was removed by distillation under reduced pressure. The aqueous phase was acidified to pH 1 with 10% HCl, at which time a white precipitate was produced. The precipitate was washed sequentially with two portions of 20 mL of water and 20 mL of ethyl acetate, and then dried under reduced pressure to give 4-(fluorenylmethoxycarbonylamino)butanoic acid (Fmoc-GABA) as a white solid in 73% (2.8 g) yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz), nuclear magnetic resonance carbon spectroscopy (13C NMR, DMSO-d6, 100 MHz) and mass spectrometry (ESI+).1H NMR (DMSO-d6, 400 MHz): δ 7.89 (d, 2H, J = 7.4 Hz), 7.44 (d, 2H, J = 7.2 Hz), 7.42 (t, 2H, J = 7.5 Hz), 7.35 (s, 1H), 7.33 (t, 2H, J = 7.0 Hz), 4.30 (d, 2H, J = 7 Hz), 4.21 (t, 1H, J = 6.7 Hz), 3.01 (q, 2H, J = 5.6 Hz), 2.20 (t, 2H, J = 7.3 Hz ), 1.63 (q, 2H, J = 7.1 Hz); 13C NMR (DMSO-d6, 100 MHz): δ 142.6, 139.4, 137.4, 128.9, 127.2, 124.2, 121.3, 120.0, 109.6, 77.5, 61.8, 51.1, 31.6; MS (ESI+): m/ z (intensity), 325.8 ([M + H]+, 100%).

References

[1] Chemical Biology and Drug Design, 2015, vol. 86, # 4, p. 837 - 848
[2] Patent: WO2018/144880, 2018, A1. Location in patent: Paragraph 64-65

FMOC-GAMMA-ABU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-GAMMA-ABU-OH Suppliers

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View Lastest Price from FMOC-GAMMA-ABU-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-γ-Abu-OH / Fmoc-4-Abu-OH 116821-47-7
Price: US $0.00-0.00/kgkg
Min. Order: 1kgkg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-13

Career Henan Chemical Co

Product: FMOC-GAMMA-ABU-OH 116821-47-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

116821-47-7, FMOC-GAMMA-ABU-OHRelated Search:

Fmoc-D-glutamic acid gamma-tert-butyl ester FMOC-GLU(OALL)-OH Fmoc-L-glutamic acid-gamma-benzyl ester FMOC-GAMMA-ABU-OH FMOC-GLU(OTBU)-OH H2O Fmoc-L-Glutamic acid 1-tert-butyl ester FMOC-ABU-OH Fmoc-L-beta-homoalanine FMOC-GLU(OBZL)-CL FMOC-ACHPA N-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC-15N ACID FMOC-GLA(OTBU)2-OH FMOC-(3S,4S)-4-AMINO-3-HYDROXY-5-PHENYL PENTANOIC ACID FMOC-GLU-OBZL FMOC-GLU(OTBU)-OSU FMOC-GLU(OTBU)-OPFP FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE FMOC-D-GLU-OTBU

RARECHEM EM WB 0021

N-(9-FLUORENYLMETHOXYCARBONYL)-GAMMA-AMINOBUTANOIC ACID

N-(9-FLUORENYLMETHOXYCARBONYL)-4-AMINOBUTYRIC ACID

N-(9-FLUORENYLMETHYLOXYCARBONYL)-GAMMA-AMINOBUTYRIC ACID

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GAMMA-AMINOBUTYRIC ACID

N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID

N-FMOC-DL-4-AMINO-BUTYRIC ACID

N-γ-Fmoc-γ-aminobutyricacid

4-(FMOC-AMINO)BUTYRIC ACID 97+%

N-(9-Fluorenylmethyloxycarbonyl)-gamma-aminobutyric acid, Fmoc-4-Abu-OH

Fmoc--aminobutyric acid (Fmoc-GABA)

FMOC-4-AMINOBUTANOIC ACID

FMOC-4-AMINO-BUTYRIC ACID

FMOC-4-AMINO-N-BUTYRIC ACID

FMOC-4-ABU-OH

FMOC-ABU(4)-OH

FMOC-L-4-AMINOBUTYRIC ACID

FMOC-GAMMA-AMINOBUTYRIC ACID

FMOC-GAMMA-ABU-OH

FMOC-GABA

FMOC-GABA-OH

FMOC-NH-(CH2)3-COOH

4-(FMOC-AMINO)BUTYRIC ACID

N-alpha-(9-Fluorenylmethyloxycarbonyl)-gamma-aminobutyricacid

4-(Fmoc-amino)butyric acid, Fmoc-GABA

4-(((9H-Fluoren-9-yl)methoxy)carbonylamino)butanoic acid

FMoc-4-Abu-OH(FMoc-4-aMinobutyric acid)

Fmoc-γ-aminobutyric acid≥ 99% (HPLC)

Fmoc-γ-Abu-OH Novabiochem

Fmoc-Gamma-OH

Fmoc-γ-Abu-OH / Fmoc-4-Abu-OH

N-Fmoc-4-aminobutyric Acid

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminobutyric Acid

N-Fmoc-g-aminobutyric Acid

Butanoic acid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-

4-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]butanoic acid

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminobutyricAcid&gt

FMOC-GAMMA-ABU-OH 1 G

4-(Fmoc-amino)butyricacid,95%

4-(9H-fluoren-9-ylmethoxycarbonylamino)butanoicaci

FMOC-GAMMA-ABU-OH USP/EP/BP

N-Fmoc-4-aminobutyric Acid,97%

Fmoc-γ-Abu-OH

116821-47-7

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Peptide Synthesis

Specialty Synthesis

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