Fmoc-L-Glutamic acid 1-tert-butyl ester
- Product Name
- Fmoc-L-Glutamic acid 1-tert-butyl ester
- CAS No.
- 84793-07-7
- Chemical Name
- Fmoc-L-Glutamic acid 1-tert-butyl ester
- Synonyms
- FMOC-L-GLU-OTBU;(S)-4-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(tert-butoxy)-5-oxopentanoic acid;FMOC-GLU-OBUT;Fmoc-Glu-OtBu 98%;FMOC-GLUTAMIC ACID-OTBU;Fmoc-l-glutamate-1-tert-butyl;Fmoc glutamic acid butyl ester;FMOC-L-GLUTAMIC ACID-A-T-BUTYLESTER;N-Fmoc-L-glutamic acid 1-tert-butyl;N-FMOC-L-GLUTAMIC ACID-1-T-BUTYL ESTER
- CBNumber
- CB0387914
- Molecular Formula
- C24H27NO6
- Formula Weight
- 425.47
- MOL File
- 84793-07-7.mol
Fmoc-L-Glutamic acid 1-tert-butyl ester Property
- Melting point:
- 78-80 °C
- Boiling point:
- 638.1±55.0 °C(Predicted)
- Density
- 1.232±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 4.46±0.10(Predicted)
- color
- White to off-white
- InChIKey
- GOPWHXPXSPIIQZ-FQEVSTJZSA-N
- SMILES
- C(OC(C)(C)C)(=O)[C@H](CCC(O)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS DataBase Reference
- 84793-07-7(CAS DataBase Reference)
Safety
- HS Code
- 29224290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
N-Bromosuccinimide Price
- Product number
- F1318
- Product name
- Fmoc-Glu-OtBu
- Packaging
- 5G
- Price
- $61
- Updated
- 2025/07/31
- Product number
- F1318
- Product name
- Fmoc-Glu-OtBu
- Packaging
- 25G
- Price
- $183
- Updated
- 2025/07/31
- Product number
- F620165
- Product name
- Fmoc-Glu-OtBu
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 276139
- Product name
- Fmoc-L-Glu-OtBu
- Packaging
- 5g
- Price
- $419
- Updated
- 2021/12/16
- Product number
- AAA0001252
- Product name
- FMOC-GLU-OTBU
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $915.92
- Updated
- 2021/12/16
Fmoc-L-Glutamic acid 1-tert-butyl ester Chemical Properties,Usage,Production
Chemical Properties
White powder crystal
Uses
Fmoc-L-Glutamic acid 1-tert-butyl ester is most often used in peptide synthesis.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
28920-43-6
45120-30-7
84793-07-7
(S)-4-Amino-5-tert-butoxy-5-oxovaleric acid (1.50 g, 7.38 mmol) was dissolved in 1,4-dioxane (40 mL) and cooled to 0 °C. An aqueous solution of sodium carbonate (196 mg, 1.85 mmol) (20 mL) and Fmoc-Cl (2.11 g, 8.16 mmol) were added sequentially. The reaction mixture was slowly warmed to room temperature and stirred for 16 hours. Upon completion of the reaction, the pH was adjusted to slightly acidic (pH ≈ 6) with 2 M hydrochloric acid, and the pH was adjusted with 1 M citric acid (ca. 80 mL) to ca. 3. The reaction mixture was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a 3:2 solvent mixture of ethyl acetate/hexane to afford (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid (3.10 g, 99%) as a white solid.1H NMR (300 MHz, CDCl3) δ: Carboxylic acid peak (1H) not observed (due to broad signal), 7.76 (d, J = 7.5 Hz, 2H), 7.61-7.58 (m, 2H), 7.42-7.26 (m, 4H), 5.45 (d, J = 7.8 Hz, 1H), 4.48-4.19 (m, 4H), 2.51-2.34 (m, 2H), 2.28-2.14 (m, 1H), 1.99 -1.88 (m, 1H), 1.47 (s, 9H); ESI MS m/z = 448 [M + Na]+.
References
[1] Patent: US2014/274951, 2014, A1. Location in patent: Paragraph 0373; 0374
Fmoc-L-Glutamic acid 1-tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-L-Glutamic acid 1-tert-butyl ester manufacturers
- Product
- Fmoc-L-Glu-OtBu 84793-07-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-11-23
- Product
- Fmoc-L-Glutamic acid 1-tert-butyl ester 84793-07-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Fmoc-L-Glutamic acid 1-tert-butyl ester 84793-07-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22