Fmoc-Leu-OH

Product Name: Fmoc-Leu-OH
CAS No.: 35661-60-0
Chemical Name: Fmoc-Leu-OH
Synonyms: FMOC-LEU-OH;FMOC-LEU;FMOC-L-LEU-OH;FMOC-LEUCINE;L-LEUCINE-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid;F-L-LEU;NPC 15199;FMOC-L-LEU
CBNumber: CB5477829
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 35661-60-0.mol

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Fmoc-Leu-OH Property

Melting point:: 152-156 °C(lit.)
alpha: -26 º (c=1,DMF 24 ºC)
Boiling point:: 486.83°C (rough estimate)
Density: 1.2107 (rough estimate)
refractive index: -25 ° (C=1, DMF)
storage temp.: Store below +30°C.
solubility: DMF (Slightly), DMSO (Slightly)
form: Solid
pka: 3.91±0.21(Predicted)
color: White to Off-White
optical activity: [α]20/D 25±2°, c = 1% in DMF
BRN: 2178254
Stability:: Hygroscopic
InChIKey: CBPJQFCAFFNICX-IBGZPJMESA-N
CAS DataBase Reference: 35661-60-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37/39-27-26
WGK Germany: 3
HS Code: 2924 29 70

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52011
Product name: Fmoc-Leu-OH
Purity: Novabiochem?
Packaging: 25g
Price: $37.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52011
Product name: Fmoc-Leu-OH
Purity: Novabiochem?
Packaging: 100g
Price: $71.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52011
Product name: Fmoc-Leu-OH
Purity: Novabiochem?
Packaging: 250g
Price: $166
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52011
Product name: Fmoc-Leu-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $299
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52011
Product name: Fmoc-Leu-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $299
Updated: 2025/07/31

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Fmoc-Leu-OH Chemical Properties,Usage,Production

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Synthesis

103321-59-1

35661-60-0

139551-97-6

The general procedure for the synthesis of Fmoc-L-leucine and compound (CAS:139551-97-6) using compound (CAS:103321-59-1) as starting material was as follows:Example 22 Synthesis of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine amide (NPC 15528). To a 10 mL THF solution containing 3.5 mL (10 mmol) of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine chloride, 1.26 mL (20 mmol) of a 29.6% ammonia solution was slowly added at room temperature. The reaction mixture was stirred for 30 min, then diluted with 100 mL of water and extracted with ethyl acetate (5 x 20 mL). The organic layers were combined and washed sequentially with 10% potassium carbonate solution, water and brine, then dried and concentrated. The product was recrystallized by ethanol to give 1.26 g (36% yield) of N-(9-fluorenylmethoxycarbonyl)-L-leucine amide as a colorless solid with a melting point of 79-80 °C.

References

[1] Patent: US5079260, 1992, A

Fmoc-Leu-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Leu-OH Suppliers

Americas 1 Belgium 4 Canada 2 China 474 Europe 6 France 3 Germany 9 Hungary 1 India 44 Israel 2 Italy 2 Japan 9 Poland 1 South Korea 1 Switzerland 7 United Kingdom 19 United States 88 Global 673

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View Lastest Price from Fmoc-Leu-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: FMOC-L-Leucine 35661-60-0
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-leu-OH 35661-60-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-11

Henan Aochuang Chemical Co.,Ltd.

Product: FMOC-L-Leucine 35661-60-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

35661-60-0, Fmoc-Leu-OHRelated Search:

L-Leucine N-CARBOBENZOXY-DL-LEUCINE L-tert-Leucine Glycine Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate FMOC-Ala-OH Fmoc-Lys(Boc)-OH FMOC-N-METHYL-TRANEXAMIC ACID Fmoc-L-Tyr(propargyl)-OH Fmoc-Gly-OH FMOC-O-tert-Butyl-L-serine Fmoc-Asn(Trt)-OH FMOC-TRANEXAMIC ACID Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH Fmoc-OSu FMOC-METRP-OH

FMOC-LEU-OH

FMOC-L-LEU-OH

FMOC-L-LEU

FMOC-L-LEUCINE

F-L-LEU

Fmoc-L-leucine,98%

L-Leucine-1-13C-N-FMOC

Fmoc-N-(isobutyl)-glycine

N-(fluorenyl-9-methoxycarbonyl)leucine

FMOC-L-LEU-OH MONOHYDRATE

Fmoc-N-(isobutyl)-Gly-OH

FMOC-L-LEUCINE extrapure

N-(9-Fluorenylmethoxycarbonyl)-L-leucine, Fmoc-L-leucine

2-(9H-fFuoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine ,98%

(2S)-4-Methyl-2-(9H-fluorene-9-ylmethoxycarbonylamino)valeric acid

(S)-2-[[(9H-Fluorene-9-yl)methoxycarbonyl]amino]-4-methylpentanoic acid

N-[(9H-Fluorene-9-yl)methoxycarbonyl]leucine

FMoc-L-leucine FMoc-Leu-OH

2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-4-METHYLPENTANOIC ACID

9-FLUORENYLMETHOXYCARBONYL-L-LEUCINE

FMOC-LEU

FMOC-LEUCINE

Fmoc-Leucine-OH

FMoc-Nleu-OH

N-FMOC-LEU-OH

N-FMOC-L-LEU

N-FMOC-L-LEUCINE

NPC 15199

N-ALPHA-FMOC-L-LEUCINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE

N-9-FLUORENYLMETHYLOXYCARBONYL-L-LEUCINE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-LEUCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LEUCINE

PPAR-GAMMA ACTIVATOR

(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid

N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-leucine, (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic acid

N-Fmoc-L-leucine Fmoc-Leu-OH

FMoc-Leu-OH >=97.0%

Fmoc-L-leucin

(9H-Fluoren-9-yl)MethOxy]Carbonyl Leu-OH

Fmoc-L-leucine≥ 99.7% (HPLC, Chiral purity)

(2R)-2-amino-3-[4-[4-[(2R)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]phenyl]propanoic acid

FMOC-LEU-OH 250 G

FMOC-LEU-OH 100 G

L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

L-LEUCINE-N-FMOC

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoicaci

Fmoc-Leu-OH Fmoc-Leu-OH

FMOC-L-Leucine USP/EP/BP

Fmoc-L-leucine, puriss, 99%

N-(9-Fluorenylmethoxycarbonyl)-L-leucine Fmoc-L-leucine 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid N-Fmoc-L-leucine

(((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine

Fmoc-Leu-OH 98%

(S)-2-(N-FMOC-Amino)-4-methylpentanoic acid

35661-60-0

35661-60-6