ChemicalBook > CAS DataBase List > Fmoc-Leu-OH

Fmoc-Leu-OH

Product Name
Fmoc-Leu-OH
CAS No.
35661-60-0
Chemical Name
Fmoc-Leu-OH
Synonyms
FMOC-LEU-OH;FMOC-LEU;FMOC-L-LEU-OH;FMOC-LEUCINE;L-LEUCINE-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid;F-L-LEU;NPC 15199;FMOC-L-LEU
CBNumber
CB5477829
Molecular Formula
C21H23NO4
Formula Weight
353.41
MOL File
35661-60-0.mol
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Fmoc-Leu-OH Property

Melting point:
152-156 °C(lit.)
alpha 
-26 º (c=1,DMF 24 ºC)
Boiling point:
486.83°C (rough estimate)
Density 
1.2107 (rough estimate)
refractive index 
-25 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
DMF (Slightly), DMSO (Slightly)
form 
Solid
pka
3.91±0.21(Predicted)
color 
White to Off-White
optical activity
[α]20/D 25±2°, c = 1% in DMF
BRN 
2178254
Stability:
Hygroscopic
InChIKey
CBPJQFCAFFNICX-IBGZPJMESA-N
CAS DataBase Reference
35661-60-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
2924 29 70
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
25g
Price
$36.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
100g
Price
$70
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
250g
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
1kg
Price
$489
Updated
2024/03/01
Sigma-Aldrich
Product number
47633
Product name
Fmoc-Leu-OH
Purity
≥97.0%
Packaging
5G
Price
$32.3
Updated
2024/03/01
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Fmoc-Leu-OH Chemical Properties,Usage,Production

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Fmoc-Leu-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Leu-OH Suppliers

Gill polypeptide biopharmaceutical (dalian) co., LTD
Tel
021-61263455 13167021076
Email
amy@glschina.com
Country
China
ProdList
8745
Advantage
58
GenChem & GenPharm (Changzhou) Co., Ltd.
Tel
0519-85720003 18861157602
Fax
0519-85720007
Email
sales03@genchem.cn
Country
China
ProdList
111
Advantage
58
Hubei Jingxiang Technology Co., Ltd.
Tel
13347833233
Email
120300346@qq.com
Country
China
ProdList
31
Advantage
58
Shandong fen Boyu Biotechnology Co.,LTD
Tel
13356310019 13356310019
Email
boyu2024@163.com
Country
China
ProdList
2735
Advantage
58
Chengdu Tachem Co., Ltd
Tel
028-61682518; 19983060238
Email
sales@tachem.cn
Country
China
ProdList
103
Advantage
58
Zepeptide Biotechnology (Shijiazhuang) Co., LTD
Tel
13383293380 18032131480
Email
649498984@qq.com
Country
China
ProdList
75
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
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View Lastest Price from Fmoc-Leu-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-leu-OH 35661-60-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
FMOC-L-Leucine 35661-60-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Fmoc-Leu-OH 35661-60-0
Price
US $0.00/gram
Min. Order
25gram
Purity
99% HPLC
Supply Ability
25 gram
Release date
2023-10-16

35661-60-0, Fmoc-Leu-OHRelated Search:


  • FMOC-LEU-OH
  • FMOC-L-LEU-OH
  • FMOC-L-LEU
  • FMOC-L-LEUCINE
  • F-L-LEU
  • Fmoc-L-leucine,98%
  • L-Leucine-1-13C-N-FMOC
  • Fmoc-N-(isobutyl)-glycine
  • N-(fluorenyl-9-methoxycarbonyl)leucine
  • FMOC-L-LEU-OH MONOHYDRATE
  • Fmoc-N-(isobutyl)-Gly-OH
  • FMOC-L-LEUCINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-L-leucine, Fmoc-L-leucine
  • 2-(9H-fFuoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine ,98%
  • (2S)-4-Methyl-2-(9H-fluorene-9-ylmethoxycarbonylamino)valeric acid
  • (S)-2-[[(9H-Fluorene-9-yl)methoxycarbonyl]amino]-4-methylpentanoic acid
  • N-[(9H-Fluorene-9-yl)methoxycarbonyl]leucine
  • FMoc-L-leucine FMoc-Leu-OH
  • 2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-4-METHYLPENTANOIC ACID
  • 9-FLUORENYLMETHOXYCARBONYL-L-LEUCINE
  • FMOC-LEU
  • FMOC-LEUCINE
  • Fmoc-Leucine-OH
  • FMoc-Nleu-OH
  • N-FMOC-LEU-OH
  • N-FMOC-L-LEU
  • N-FMOC-L-LEUCINE
  • NPC 15199
  • N-ALPHA-FMOC-L-LEUCINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-LEUCINE
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LEUCINE
  • PPAR-GAMMA ACTIVATOR
  • (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid
  • N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-leucine, (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic acid
  • N-Fmoc-L-leucine Fmoc-Leu-OH
  • FMoc-Leu-OH >=97.0%
  • Fmoc-L-leucin
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Leu-OH
  • Fmoc-L-leucine≥ 99.7% (HPLC, Chiral purity)
  • (2R)-2-amino-3-[4-[4-[(2R)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]phenyl]propanoic acid
  • FMOC-LEU-OH 250 G
  • FMOC-LEU-OH 100 G
  • L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • L-LEUCINE-N-FMOC
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoicaci
  • Fmoc-Leu-OH Fmoc-Leu-OH
  • FMOC-L-Leucine USP/EP/BP
  • Fmoc-L-leucine, puriss, 99%
  • N-(9-Fluorenylmethoxycarbonyl)-L-leucine Fmoc-L-leucine 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid N-Fmoc-L-leucine
  • (((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine
  • 35661-60-0
  • 35661-60-6
  • C21H323NO4
  • CH32CHCH2CHNHFMOCCOOH