1-METHYL-1H-INDOL-4-AMINE
- Product Name
- 1-METHYL-1H-INDOL-4-AMINE
- CAS No.
- 85696-95-3
- Chemical Name
- 1-METHYL-1H-INDOL-4-AMINE
- Synonyms
- 1-methylindol-4-amine;1-methyl-4-indolamine;4-Amino-1-methylindole;4-AMINO-N-METHYLINDOLE;1-METHYL-1H-INDOL-4-AMINE;1-METHYL-1H-INDOLE-4-AMINE;1H-Indol-4-amine, 1-methyl-;1-METHYL-1H-INDOL-4-YLAMINE
- CBNumber
- CB8167042
- Molecular Formula
- C9H10N2
- Formula Weight
- 146.19
- MOL File
- 85696-95-3.mol
1-METHYL-1H-INDOL-4-AMINE Property
- Boiling point:
- 328.0±15.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.04±0.10(Predicted)
- form
- solid
- Appearance
- Brown to black Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M321575
- Product name
- 1-Methyl-1H-indol-4-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0061752
- Product name
- 1-Methyl-1H-indol-4-amine
- Purity
- 99.56%
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- CS-0061752
- Product name
- 1-Methyl-1H-indol-4-amine
- Purity
- 99.56%
- Packaging
- 250mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- OR913289
- Product name
- 4-Amino-N-methylindole
- Purity
- 97%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- X4949
- Product name
- 1-Methyl-1H-indol-4-ylamine
- Packaging
- 100mg
- Price
- $257
- Updated
- 2021/12/16
1-METHYL-1H-INDOL-4-AMINE Chemical Properties,Usage,Production
Synthesis
91482-63-2
85696-95-3
General procedure for the synthesis of 4-amino-N-methylindole from 1-methyl-4-nitro-1H-indole: Reduced iron powder (3.36 g, 60 mmol) was added batchwise to a boiling mixture containing 1-methyl-4-nitro-1H-indole (40 mmol), concentrated hydrochloric acid (5 mL) and ethanol (100 mL). The resulting suspension was refluxed for 1 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with ammonia, filtered to remove iron residue, and washed with ethanol (30 mL). The filtrate was evaporated and concentrated, then diluted with ethyl acetate (100 mL). The organic phase was washed sequentially with brine (25 mL) and water (2 x 50 mL), dried with magnesium sulfate, and the solvent was evaporated to give the residue 1-methyl-1H-indol-4-ylamine (7). The product was a gray solid with a melting point of 95-96 °C in 85% yield.1H NMR (300 MHz, CDCl3) δ 7.02 (t, 1H, J = 7.8 Hz, H-6), 6.86 (d, 1H, J = 3.3 Hz, H-2), 6.74 (d, 1H, J = 8.7 Hz, H-5), 6.33 (d, 1H, J = 8.7 Hz , H-7), 6.32 (d, 1H, J = 3.3 Hz, H-3), 3.82 (br s, 2H, NH2-4), 3.61 (s, 3H, CH3-1). Calculated values for elemental analysis (C9H10N2): C, 73.94; H, 6.89; N, 19.16; measured values: C, 73.80; H, 6.80; N, 19.30%.
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[2] Tetrahedron Letters, 2017, vol. 58, # 13, p. 1324 - 1325
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3417 - 3427
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 8, p. 1104 - 1107
[5] Patent: US2009/227575, 2009, A1. Location in patent: Page/Page column 21; 17
1-METHYL-1H-INDOL-4-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-METHYL-1H-INDOL-4-AMINE manufacturers
- Product
- 4-amino-1-methylindole 85696-95-3
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 1-methylindol-4-amine 85696-95-3
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09