ChemicalBook > CAS DataBase List > 4-(4-Fluorobenzoyl)butyric acid

4-(4-Fluorobenzoyl)butyric acid

Product Name: 4-(4-Fluorobenzoyl)butyric acid
CAS No.: 149437-76-3
Chemical Name: 4-(4-Fluorobenzoyl)butyric acid
Synonyms: 4-(4-FL;Ezetimibe-15;CAS:149437-76-3;CHEMBRDG-BB 4002813;TIMTEC-BB SBB000492;TIMTEC-BB SBB010216;4-(4-Fluorobenzoyl)b;Ezetimibe Impuriry P;4-(4-Fluorobenzoyl)butyric;4-FLUORO BENZOYL BUTYRIC ACID
CBNumber: CB8168564
Molecular Formula: C11H11FO3
Formula Weight: 210.2
MOL File: 149437-76-3.mol

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4-(4-Fluorobenzoyl)butyric acid Property

Melting point:: 142-144°C
Boiling point:: 394.6±22.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Methanol
form: Solid
pka: 4.59±0.10(Predicted)
color: Off-White
InChI: InChI=1S/C11H11FO3/c12-9-6-4-8(5-7-9)10(13)2-1-3-11(14)15/h4-7H,1-3H2,(H,14,15)
InChIKey: ZBQROUOOMAMCQW-UHFFFAOYSA-N
SMILES: C(C1C=CC(F)=CC=1)(=O)CCCC(=O)O
CAS DataBase Reference: 149437-76-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37
Hazard Note: Irritant
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R169609
Product name: 5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: R169609
Product name: 5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID
Purity: Aldrich
Packaging: 50mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: F0476
Product name: 4-(4-Fluorobenzoyl)butyric Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: F0476
Product name: 4-(4-Fluorobenzoyl)butyric Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $50
Updated: 2025/07/31

TRC

Product number: F588495
Product name: 4-Fluorophenyl-5’-oxobutyricAcid
Packaging: 5g
Price: $140
Updated: 2021/12/16

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4-(4-Fluorobenzoyl)butyric acid Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

4-Fluorophenyl-5’-oxobutyric Acid (cas# 149437-76-3) is a compound useful in organic synthesis.

Synthesis

108-55-4

462-06-6

149437-76-3

4-(4-Fluorobenzoyl)butyric acid was synthesized as follows: 250 g of anhydrous AlCl3 (1.87 mol) and 300 mL of fluorobenzene (307.5 g; 3.2 mol) were added to a 2 L three-necked round-bottomed flask, and the mixture was cooled to 5 °C in an ice bath. A turbid suspension of 100 g of glutaric anhydride (0.86 mol) dissolved in 400 mL of fluorobenzene (4.3 mol) was slowly added through the addition funnel over 45 min, keeping the reaction temperature below 12 °C. The reaction mixture was gradually warmed to room temperature and stirred for 90 min and the completion of the reaction was monitored by NMR. The reaction mixture was cooled to 0 to 5 °C and 700 mL of a cold aqueous solution of 1N HCl was carefully added to quench unreacted AlCl3, keeping the temperature below 20 °C initially and not exceeding 40 °C later. The mixture was poured into 2 L of a 1:1 mixture of water and ice (v/w) to precipitate the crude product, and the white suspension was filtered and washed well with water. The white solid was dissolved in 3 L of 5% NaHCO3 saturated aqueous solution, heated in a steam bath for 1 h and then filtered through a diatomaceous earth pad while hot. The filtrate was cooled to room temperature, adjusted to pH 1 by adding about 320 mL of concentrated HCl drop by drop, the product crystallized and stirred in an ice bath for 30 minutes. Filtered, the wet filter cake was washed with ice-cold water and dried under vacuum at 50 °C for 16 h. 143.2 g of 4-(4-fluorobenzoyl)butyric acid was obtained with a melting point of 141 to 142 °C and a yield of 79.3%.

References

[1] Patent: WO2004/99132, 2004, A2. Location in patent: Page 7-8
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 15, p. 4424 - 4426
[3] Patent: CN106397292, 2017, A. Location in patent: Paragraph 0053; 0083; 0084
[4] Patent: US2006/135755, 2006, A1. Location in patent: Page/Page column 15
[5] Patent: EP1137634, 2005, B1. Location in patent: Page/Page column 9

4-(4-Fluorobenzoyl)butyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(4-Fluorobenzoyl)butyric acid manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-(4-Fluorobenzoyl) butyric acid 149437-76-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(4-Fluorobenzoyl)butyric acid 149437-76-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-22

Wuhan wingroup Pharmaceutical Co., Ltd

Product: 4-(4-Fluorobenzoyl)butyric acid 149437-76-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100MT/Month
Release date: 2021-08-02

149437-76-3, 4-(4-Fluorobenzoyl)butyric acid Related Search:

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CHEMBRDG-BB 4002813

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4-(p-Fluorobenzoyl)-butyric acid

TIMTEC-BB SBB000492

TIMTEC-BB SBB010216

4-(4-FL

Ezetimibe-15

5-(4-FLUOROPHENYL)-5-OXOPENTANOIC ACID 4-(4-FLUOROPHENYL) BUTYRIC ACID

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4-FLUORO--OXO-BENZENEPENTANOIC ACID

4-fluorophenyl-5-ketopentanoic acid

5-(4-fluorophenyl)-5-ketopentanoic acid

4-fluoro-delta-oxo-benzenepentanoic acid

5-(4'-Fluorophenyl)-5-oxopenta

4-(4-Fluorobenzoyl)b

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Benzenepentanoic acid,4-fluoro-d-oxo-

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4-(4-Fluorobenzoyl)ButyricAci

Ezetimibe Impuriry P

4-(4-FLUOROBENZYL)BUTYRIC ACID

5-(4-Fluorophenyl)-5-Ketopentanoic acid(Keto acid)

4-(4'-Fluorophenyl)butyric acid (Ezetimibe Impurity)

4-Fluoro-δ-oxobenzenepentanoic acid

5-(4'-Fluorophenyl)-5-oxopentanoicacid

4-Fluorophenyl-5’-oxobutyric Acid

4-(4'-Fluorophenyl)butyric acid

CAS:149437-76-3

Baclofen Impurity: 5-(4-Fluorophenyl)-5-oxopentanoic acid

149437-76-3

49437-76-3

C11H1FO3

Aromatics

Intermediate of ezetimibe

Acids & Esters

Fluorine Compounds

149437-76-3