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TRIOCTANOIN

Product Name
TRIOCTANOIN
CAS No.
538-23-8
Chemical Name
TRIOCTANOIN
Synonyms
TRICAPRYLIN;GLYCEROL TRICAPRYLATE;GLYCERYL TRICAPRYLATE;Caprylic triglyceride;Tricaprilin;CAPRYLIN;TRICAPRYLIN (C8:0);Glycerol trioctanoate;Glyceryl tricaprylate-caprate;RATO
CBNumber
CB8170985
Molecular Formula
C27H50O6
Formula Weight
470.68
MOL File
538-23-8.mol
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TRIOCTANOIN Property

Melting point:
9-10 °C
Boiling point:
233 °C/1 mmHg (lit.)
Density 
0.956 g/mL at 20 °C (lit.)
vapor pressure 
0Pa at 25℃
refractive index 
n20/D 1.448
Flash point:
225 °C
storage temp. 
-20°C
solubility 
Miscible with most organic solvents including ethanol (95%). Captex 8000 is insoluble in water.
form 
Liquid
color 
Colourless
Odor
at 100.00?%. odorless
Water Solubility 
65mg/L at 20℃
BRN 
1717202
LogP
9.2 at 20℃
CAS DataBase Reference
538-23-8(CAS DataBase Reference)
EPA Substance Registry System
Glycerol trioctanoate (538-23-8)
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Safety

Safety Statements 
23-24/25
WGK Germany 
-
RTECS 
YJ7700000
HS Code 
29159000
Hazardous Substances Data
538-23-8(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 33300mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T9126
Product name
Glyceryl trioctanoate
Purity
≥99%
Packaging
100ml
Price
$74.1
Updated
2024/03/01
Sigma-Aldrich
Product number
T9126
Product name
Glyceryl trioctanoate
Purity
≥99%
Packaging
1l
Price
$404
Updated
2024/03/01
TCI Chemical
Product number
T0365
Product name
Tricaprylin
Purity
>93.0%(GC)
Packaging
25mL
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
26952
Product name
1,2,3-Trioctanoyl Glycerol
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26952
Product name
1,2,3-Trioctanoyl Glycerol
Packaging
100mg
Price
$57
Updated
2024/03/01
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TRIOCTANOIN Chemical Properties,Usage,Production

Description

1,2,3-Trioctanoyl glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl glycerol (260 g/kg diet) increases hepatic and adipose tissue glucose-6-phosphate dehydrogenase (G6PDH), citrate cleavage enzyme (CCE), and malic enzyme activities in rats. It induces nuclear edema and cytolysis in tumor cells, but not normal hepatic cells, in a murine hepatic carcinoma model.

Chemical Properties

clear colorless to yellow viscous liquid

Chemical Properties

Tricaprylin occurs as a clear, colorless to pale-yellow liquid. It forms crystals from acetone/ethanol (95%). Tricaprylin is odorless.

Uses

Glytex(R) 273 is a low viscosity polyol ester suggested for use as a synthetic fiber lubricant. It offers a balance of moderate volatility and low varnishing behavior. For low to moderate denier polyester and nylon filament and staple yarn applications. Product Data Sheet

Uses

glyceryl trioctanoate is an emollient with skin-softening abilities.

Uses

tricaprylin is a skin-conditioning agent.

Production Methods

Tricaprylin is a triglyceride manufactured by esterification of caprylic acid and glycerin.

Definition

ChEBI: A triglyceride obtained by acylation of the three hydroxy groups of glycerol by octanoic acid. Used as an alternative energy source to glucose for patients with mild to moderate Alzheimer's disease.

General Description

Odorless viscous clear colorless to amber-brown liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

TRIOCTANOIN is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. TRIOCTANOIN is incompatible with strong oxidizers. .

Fire Hazard

TRIOCTANOIN is combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Tricaprylin is used in pharmaceutical preparations as a neutral carrier, absorption promoter, and solubilizer for active drugs. It has been used as an oily phase to prepare water-in-oil-in-water multiple emulsions for incorporating water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine, and also for obtaining stable microcapsules.
Tricaprylin acts as a vehicle for topical creams and lotions, and cosmetic preparations. It is used as a penetration-enhancing lipid base with excellent emollient and skin-smoothing properties. Owing to its non-greasy components and low viscosity, it has very good spreadability. In spite of being skin-permeable, tricaprylin does not obstruct natural skin respiration, and hence it is used in baby oils, massage oils, and face masks. It is an excellent dispersant, and acts as a solubilizer, wetting agent and binder in color cosmetics. Being readily miscible with natural oils and surfactants, tricaprylin is used as the fat component in two-phase foam baths. It is used in sunscreen creams and oils because of its compatibility with organic and inorganic filter agents. It is also used as a fixative for perfumes/fragrances.

Biochem/physiol Actions

Glyceryl trioctanoate might serve as a skin softening agent. It possesses caprylic acid as the aliphatic chain.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Safety

Tricaprylin is used in pharmaceutical and cosmetic formulations. The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of tricaprylin has not been associated with significant irritation in rabbit skin. However, as a penetration enhancer, tricaprylin may allow other chemicals to penetrate deeper into the skin, increasing their concentration so that they may reach the bloodstream. Ocular exposures of tricaprylin were found to be only mildly irritating to rabbit eyes. Little or no acute, subchronic, or chronic oral toxicity was observed in animal studies unless levels approached a significant percentage of caloric intake. Subcutaneous injections of tricaprylin in rats over a period of 5 weeks caused a granulomatous reaction.
Tricaprylin has not been found to be teratogenic in rats, mice, or hamsters, but some reproductive effects have been seen in rabbits. Dose-related central nervous system toxicity in dogs has also been observed.
LD50 (mouse, IP): >27.8 g/kg
LD50 (mouse, IV): 3.7 g/kg
LD50 (mouse, oral): 29.6 g/kg
LD50 (mouse, SC): >27.8 g/kg
LD50 (rat, IP): 0.05 g/kg
LD50 (rat, IV): 4 g/kg
LD50 (rat, oral): 33.3 g/kg

Carcinogenicity

In F344 rats given 10 mL/kg of tricaprylin by gavage daily for 2 years, there is significant increase in the incidence of squamous cell papillomas of the forestomach, compared to controls .

storage

Tricaprylin is classified as a stable compound. It has high stability against oxidation and is not heat sensitive. Even in hot climates cooling is not necessary. However, exposure to high temperatures near the flash point (246℃) should be avoided. Owing to its very low water content, it is not sensitive to hydrolytic and microbial splitting. Although polymerization of tricaprylin will not occur, it is reported to decompose into carbon monoxide and carbon dioxide.
Tricaprylin should be stored in well-closed containers, protected from light, in a dry place at ambient temperature. High-density polyethylene, polypropylene, metal (aluminum), and glass are suitable for packaging. Some plastics, especially those containing plasticizers, can become brittle or expand in the presence of tricaprylin. Polystyrene and polyvinyl chloride are not suitable for its storage. Tricaprylin has a high tendency to migrate, and therefore care should be taken when selecting seal-closure elastomer material.

Incompatibilities

Tricaprylin is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (epidural injections).

TRIOCTANOIN Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIOCTANOIN Suppliers

Suzhou SouthEast Pharmaceuticals Co.,Ltd
Tel
0512-62729923 18915562593
Email
ophelia_hu@163.com
Country
China
ProdList
16
Advantage
58
Taizhou Shikang Pharmaceutical Technology Co., Ltd
Tel
13852603816 13852603816
Email
chunxiaohong@sina.com
Country
China
ProdList
49
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Qingdao Vochem Co., Ltd.
Tel
532-88066095 18661779210
Email
vochem@vochem.com
Country
China
ProdList
98
Advantage
60
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
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View Lastest Price from TRIOCTANOIN manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
TRIOCTANOIN 538-23-8
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-09
Hebei Weibang Biotechnology Co., Ltd
Product
TRIOCTANOIN 538-23-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-25
Henan Fengda Chemical Co., Ltd
Product
TRIOCTANOIN 538-23-8
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

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