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L-Selenomethionine

Product Name
L-Selenomethionine
CAS No.
3211-76-5
Chemical Name
L-Selenomethionine
Synonyms
SEMET;SELENO-L-METHIONINE;(S)-2-aMino-4-(Methylselanyl)butanoic acid;-SeL;enomethionine;L-SELENOMETHIONINE;S-Selenomethionine;L-SELENOMETHINONINE;L-SELENIUMETHIONINE;THALLIUM ETHYLSUFATE
CBNumber
CB8183929
Molecular Formula
C5H11NO2Se
Formula Weight
196.11
MOL File
3211-76-5.mol
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L-Selenomethionine Property

Melting point:
265 °C
alpha 
18 º (c=1, 1N HCl)
Boiling point:
320.8±37.0 °C(Predicted)
refractive index 
18 ° (C=0.5, 2mol/L HCl)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
pka
2.26±0.10(Predicted)
color 
white to off-white
Water Solubility 
soluble
Merck 
14,8441
InChI
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKey
RJFAYQIBOAGBLC-BYPYZUCNSA-N
SMILES
C(O)(=O)[C@@H](N)CC[Se]C
LogP
0.152 (est)
CAS DataBase Reference
3211-76-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/25-33-50/53
Safety Statements 
20/21-28-45-60-61-28A
RIDADR 
UN 3283 6.1/PG 2
WGK Germany 
3
RTECS 
EK7713840
F 
10
HazardClass 
6.1
PackingGroup 
III
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S3132
Product name
Seleno-L-methionine
Purity
≥98% (TLC), powder
Packaging
100mg
Price
$205.06
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3398
Product name
S-Selenomethionine
Purity
certified reference material, pharmaceutical secondary standard
Packaging
200MG
Price
$186
Updated
2025/07/31
Sigma-Aldrich
Product number
561505
Product name
L-Selenomethionine
Purity
L Selenomethionine increases the expression of glutathione peroxidase.
Packaging
250 mg
Price
$332
Updated
2025/07/31
Sigma-Aldrich
Product number
561505
Product name
L-Selenomethionine
Purity
L Selenomethionine increases the expression of glutathione peroxidase.
Packaging
1 g
Price
$682
Updated
2025/07/31
Sigma-Aldrich
Product number
1611955
Product name
Selenomethionine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$375
Updated
2025/07/31
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L-Selenomethionine Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

A compound shown to increase expression of glutathione peroxidase

Uses

L-Selenomethionine has been used:

  • in toxicity studies in Japanese Medaka embryos
  • to study its effects on selenium status indicators in pregnant long-tailed macaques (Macaca Fascicularis)
  • to label proteins for single wavelength anomalous dispersion (SAD) phasing

Definition

ChEBI: The L-enantiomer of selenomethionine.

General Description

Seleno-L-Methionine (SeMet), an organic form of selenium is found in Cupriavidus metallidurans.

Biochem/physiol Actions

Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet.

Synthesis

2185-03-7

37773-10-7

3211-76-5

Under nitrogen protection, 13.75 g of L-homoserine lactone hydrochloride was mixed with 40 mL of N,N-dimethylformamide (DMF) and stirred until completely dissolved. Subsequently, 15.2 g of methyl selenate (CAS:37773-10-7) was dissolved in 20 mL of DMF and slowly added to the above reaction system. The reaction was heated and refluxed for 2 hours. Upon completion of the reaction, the pH of the reaction system was adjusted to 6.0 with aqueous acetic acid and a white solid was precipitated. The resulting solid was dissolved in a mixed solvent of water and ethanol for recrystallization to obtain L-selenomethionine. The total yield of this synthetic route was 72.11%, the chemical purity of the product was greater than 99% and the enantiomeric excess value (ee) was greater than 99%.

References

[1] Patent: CN106928110, 2017, A. Location in patent: Paragraph 0028; 0030

L-Selenomethionine Preparation Products And Raw materials

Raw materials

Selenium Benzyl chloride Ethanol N,N-Dimethylformamide Acetone Hydrogen peroxide Sodium chloride Tributyl borate Sodium Hydrogen bromide Tetrahydrofuran Diethyl ether Benzene Methyllithium Hydrochloric acid Sodium bicarbonate Methanol Sodium hydroxide L-Methionine Phosphorus pentoxide Magnesium Iodomethane Sulfuric acid Ammonia

Preparation Products

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L-Selenomethionine Suppliers

Belgium 2 China 331 Europe 2 Germany 2 India 27 Japan 5 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 10 United States 45 Global 427
Apollo Scientific Ltd.
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View Lastest Price from L-Selenomethionine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
L-Selenomethionine 3211-76-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-19
Changsha YuTeng New Materials Co., Ltd.
Product
L-Selenomethionine 3211-76-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
50kg/M
Release date
2025-03-03
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Selenomethionine 3211-76-5
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20

3211-76-5, L-SelenomethionineRelated Search:

Fmoc-Selenomethionine Selenomethionine[75Se] DL-Selenomethionine L-Selenomethionine D L-SELENOMETHIONINE 99+%,DL-SELENOMETHIONINE,DL-SELENOMETHIONINE-13C1 (METHYL-13C) 99 BOC-DL-SELENOMETHIONINE N-ALPHA-FMOC-L-SELENOMETHIONINE,FMOC-L-SELENOMETHIONINE BOC-L-SELENOMETHIONINE FMOC-DL-SELENOMETHIONINE N-ACETYL-L-SELENOMETHIONIN D-SELENOMETHIONINE L-SELENOMETHIONINE BLEND DL-Selenomethionine-13C1 (methyl-13C1),DL-SELENOMETHIONINE-METHYL-13C1 Selenium (as Selenomethionine) SELENOMETHIONINE, L-(+)-(RG) SELENOMETHIONINE-ENRICHEDSALMON L-Selenomethionine Blend, 5,000 μg/g SELENOMETHIONINE USP(CRM STANDARD)

  • (S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID
  • (S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID
  • SEMET
  • SELENOMETHIONINE, L-(+)-
  • SELENO-L-METHIONINE
  • L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID
  • L-(+)-SELENOMETHIONINE
  • L-SELENOMETHIONINE
  • The L-selenoMethionine
  • L-SELENOMETHINONINE
  • Seleno-L-methionineUSP, 97-104% (HPLC)
  • SELENOMETHIONINE, L-(+)-(P)
  • (2S)-2-amino-4-(methylselanyl)butanoic acid
  • selenium compound, n.o.s. (l-selenomethi onine usp
  • L(+)-SELENOMETHIONINE 99+% E.E.
  • (S)-2-AMINO-4-(METHYLSELENYL)BUTYRIC ACID
  • L(+)-Selenomethionine, ee 99+%, 99+%
  • Butanoic acid, 2-amino-4-(methylseleno)-, (2S)-
  • L-SELENOMETHIONINE SELENO-L-METHIONINE L-SE-MET-OH
  • L-selenomethionine （L-se-Met-OH）
  • BUTYRICACID,2-AMINO-4-(METHYLSELENYL)-,L-
  • Butanoic acid, 2-amino-4-(methylseleno)-, (S)-
  • L(+)-Selenomethionine, ee 99+%
  • (2S)-2-Amino-4-(methylseleno)butyric acid
  • L(+)-Selenomethionine,99+%,ee 99+%
  • THALLIUM ETHYLSUFATE
  • (S)-(+)-2-Amino-4-(methylseleno)butanoic acid, (S)-2-Amino-4-(methylseleno)butyric acid, L-Selenomethionine, Seleno-L-methionine
  • L-SELENOMETHIONINE 0.5%
  • L-SELENOMETHIONINE USP
  • L-Selenomethionine ,98%
  • Seleno-L-methionine,(S)-2-Amino-4-(methylseleno)butyric acid
  • SELENO-L-METHIONINE(-20℃)
  • L-(+)-SelenoMethionine / 2-AMino-4-(Methylseleno)butanoic acid
  • (2S)-2-Amino-4-(methylseleno)butanoic acid
  • L-Seleno-L-methionine
  • (S)-2-aMino-4-(Methylselanyl)butanoic acid
  • L(+)-SelenoMethionine, ee 99+%, 99+% 2.5GR
  • enomethionine
  • -SeL
  • L-Selenomethionine&gt
  • L-SELENIUMETHIONINE
  • L-Selenomethionine USP/EP/BP
  • laevo-selenomethionine
  • L- (+)-Selenomethionine (Selenium content: ~40%)
  • L-(+)-Selenomethionine, Antioxidant agent
  • Seleno-<sc>L</sc>-methionine
  • S-Selenomethionine
  • 3211-76-5
  • C5HM11NO2Se
  • CH3SeCH2CH2CHNH2CO2H
  • Cancer Research
  • BioChemical
  • Chemopreventive Agents
  • Antioxidant and Free Radical Scavengers
  • Se (Selenium) Compounds
  • Semimetal Compounds
  • Classes of Metal Compounds
  • Seleno Amino Acid