ChemicalBook > CAS DataBase List > 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol

1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol

Product Name
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
CAS No.
685514-01-6
Chemical Name
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
Synonyms
1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol;1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol;1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol;1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol;1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-;1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-sulfonic acid
CBNumber
CB81871753
Molecular Formula
C16H26N2OSi
Formula Weight
290.48
MOL File
685514-01-6.mol
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1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Property

Boiling point:
341.6±35.0 °C(Predicted)
Density 
1.03±0.1 g/cm3(Predicted)
pka
8.50±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-B1523
Product name
1H-Pyrrolo[2,3-b]pyridin-5-ol,1-[tris(1-methylethyl)silyl]-
Packaging
250mg
Price
$56
Updated
2021/12/16
ChemScene
Product number
CS-B1523
Product name
1H-Pyrrolo[2,3-b]pyridin-5-ol,1-[tris(1-methylethyl)silyl]-
Packaging
1g
Price
$112
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ORS0004629
Product name
1-[TRIS-(1-METHYLETHYL)SILYL]-1H-PYRROLO[2,3-B]PYRIDIN-5-OL
Purity
95.00%
Packaging
5MG
Price
$498.83
Updated
2021/12/16
ChemScene
Product number
CS-B1523
Product name
1H-Pyrrolo[2,3-b]pyridin-5-ol,1-[tris(1-methylethyl)silyl]-
Packaging
5g
Price
$336
Updated
2021/12/16
Matrix Scientific
Product number
179557
Product name
1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol
Packaging
1g
Price
$826
Updated
2021/12/16
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1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Chemical Properties,Usage,Production

Synthesis

Add 10.8g (34mmol) of (1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 120mL of tetrahydrofuran to a round bottom flask equipped with a magnetic stirrer, an inert gas source and a separating funnel, and stir to dissolve; Add 34mL of 1mol/L sodium hydroxide solution and 4.60g (40.6mmol) of 30% hydrogen peroxide dropwise at 0°C. After the addition, React at 0°C for 1 hour and detect the reaction by TLC. Add 4.8g (20.24mmol) of sodium thiosulfate, adjust to pH=5 with 2mol/L hydrochloric acid, extract with ethyl acetate (2x200mL), combine the organic phases, wash with saturated brine in turn, dry with a sodium sulfate, and reduce Concentrate under pressure. The residue was purified by silica gel column chromatography [eluent: dichloromethane] to obtain 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 9.4g, yield 95.0%.

1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol manufacturers

Career Henan Chemical Co
Product
1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- 685514-01-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-14
Shanghai Yingrui Biopharma Co., Ltd.
Product
1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- 685514-01-6
Price
US $0.00/KG
Min. Order
0KG
Purity
99%
Supply Ability
100t
Release date
2018-03-06

685514-01-6, 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-olRelated Search:

2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 1H-PYRROLO[2,3-B]PYRIDIN-5-OL

  • 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
  • 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
  • 1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol
  • 1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol
  • 1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-sulfonic acid
  • 1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol
  • 1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol
  • 1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol
  • 685514-01-6
  • C16H26N2OSi