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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Product Name
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
CAS No.
1228779-96-1
Chemical Name
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Synonyms
124267;abt-1-199;EOS-60659;THP-sulfonamide;Venclexta Impurity 2;ABT-199 intermedate3;Venetoclax Intermediate;Venetoclax Intermediate 4;3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide;3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide
CBNumber
CB02735683
Molecular Formula
C12H17N3O5S
Formula Weight
315.35
MOL File
1228779-96-1.mol
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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Property

Melting point:
188 - 191°C
Boiling point:
542.0±60.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.58±0.60(Predicted)
form 
Solid
color 
Yellow to Dark Yellow
CAS DataBase Reference
1228779-96-1
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
132849
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Purity
97%
Packaging
5g
Price
$62
Updated
2021/12/16
Apolloscientific
Product number
OR55052
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$66
Updated
2021/12/16
SynQuest Laboratories
Product number
8H69-1-7N
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$72
Updated
2021/12/16
AK Scientific
Product number
0022AP
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$77
Updated
2021/12/16
ChemScene
Product number
CS-0010860
Product name
3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide
Packaging
10g
Price
$84
Updated
2021/12/16
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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Usage,Production

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Suppliers

Changzhou Nuobailang Biomedical Technology Co., Ltd.
Tel
13861006441
Email
780864642@qq.com
Country
China
ProdList
23
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ShangHai Onsyn-Chemical Technology Co., Ltd.
Tel
021-58359326 13124831025
Fax
+86-21-58359326
Email
angsihuaxue@126.com
Country
China
ProdList
246
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55
NANJING ZENJI PHARMACEUTICALS
Tel
025-58231105-8151
Fax
025-83172562
Email
marketing@zenjipharma.com
Country
China
ProdList
441
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EVERSHINE CHEMICAL CO., LIMITED
Tel
0571-58120272 17185714011
Email
3506894070@qq.com
Country
China
ProdList
86
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58
NANJING ZENJI PHARMACEUTICALS
Tel
025-58231105-8151 15190133791;
Email
marketing@zenjipharma.com
Country
China
ProdList
441
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Nanjing Lebang Pharmaceutical Technology Co., Ltd
Tel
18860950986
Email
tangmanman@lebangpharma.com
Country
China
ProdList
521
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58
YJ Pharma
Tel
13962794339 13962794339
Email
3686954964@qq.com
Country
China
ProdList
165
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
Taizhou Chemedir Biopharm-tech. Co., Ltd
Tel
0523-86200218 18994667082
Fax
+86 523-86200613
Email
sale1_cmd@chemedir.com
Country
China
ProdList
65
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64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9414
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66
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View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide 1228779-96-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-11
Hangzhou ICH Biofarm Co., Ltd
Product
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide 1228779-96-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-06-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 1228779-96-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

1228779-96-1, 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMideRelated Search:


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