3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Product Name: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
CAS No.: 1228779-96-1
Chemical Name: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Synonyms: 124267;abt-1－199;EOS-60659;THP-sulfonamide;Venclexta Impurity 2;ABT-199 intermedate3;Venetoclax Intermediate;Venetoclax Intermediate 4;3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide;3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide
CBNumber: CB02735683
Molecular Formula: C12H17N3O5S
Formula Weight: 315.35
MOL File: 1228779-96-1.mol

More

Less

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Property

Melting point:: 188 - 191°C
Boiling point:: 542.0±60.0 °C(Predicted)
Density: 1.412±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.58±0.60(Predicted)
form: Solid
color: Yellow to Dark Yellow
CAS DataBase Reference: 1228779-96-1

More

Less

Safety

HS Code: 2932990090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 132849
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Purity: 97%
Packaging: 5g
Price: $62
Updated: 2021/12/16

Apolloscientific

Product number: OR55052
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H69-1-7N
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: 0022AP
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $77
Updated: 2021/12/16

ChemScene

Product number: CS-0010860
Product name: 3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide
Packaging: 10g
Price: $84
Updated: 2021/12/16

More

Less

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Usage,Production

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Suppliers

China 198 India 6 United Kingdom 1 United States 6 Global 211

Changzhou Nuobailang Biomedical Technology Co., Ltd.

Tel: 13861006441
Email: 780864642@qq.com
Country: China
ProdList: 23
Advantage: 58

ShangHai Onsyn-Chemical Technology Co., Ltd.

Tel: 021-58359326 13124831025
Fax: +86-21-58359326
Email: angsihuaxue@126.com
Country: China
ProdList: 246
Advantage: 55

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151
Fax: 025-83172562
Email: marketing@zenjipharma.com
Country: China
ProdList: 437
Advantage: 58

EVERSHINE CHEMICAL CO., LIMITED

Tel: 0571-58120272 17185714011
Email: 3506894070@qq.com
Country: China
ProdList: 85
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151 15190133791;
Email: marketing@zenjipharma.com
Country: China
ProdList: 437
Advantage: 58

Nanjing Lebang Pharmaceutical Technology Co., Ltd

Tel: 18860950986
Email: tangmanman@lebangpharma.com
Country: China
ProdList: 564
Advantage: 58

YJ Pharma

Tel: 13962794339 13962794339
Email: 3686954964@qq.com
Country: China
ProdList: 189
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9513
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

More

Less

View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide 1228779-96-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

Hangzhou ICH Biofarm Co., Ltd

Product: 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide 1228779-96-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 1228779-96-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1228779-96-1, 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMideRelated Search:

FETAL BOVINE SERUM USA ORIGIN GAMMA DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE Apalutamide 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 4-Bromo-2-fluoro-N-methylbenzamide 2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

THP-sulfonamide

3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide

abt-1－199

3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide

Venclexta Impurity 2

3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide

124267

Venetoclax Intermediate

Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]-

ABT-199 intermedate3

EOS-60659

Venetoclax Intermediate 4

3-nitro-4-(((tetrahydro-2H-pyran-4 yl)methyl)amino)benzenesulfonamide(For export only)

3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesu...

3-nitro-4-(((tetrahyydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide

2-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide

1228779-96-1

1629047-84-9

1228779-96-1