3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Product Name: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
CAS No.: 1228779-96-1
Chemical Name: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Synonyms: 124267;abt-1－199;EOS-60659;THP-sulfonamide;Venetoclax Inter.;Venclexta Impurity 2;ABT-199 intermedate3;Venetoclax Intermediate;Venetoclax Intermediate 4;3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide
CBNumber: CB02735683
Molecular Formula: C12H17N3O5S
Formula Weight: 315.35
MOL File: 1228779-96-1.mol

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Property

Melting point:: 188 - 191°C
Boiling point:: 542.0±60.0 °C(Predicted)
Density: 1.412±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.58±0.60(Predicted)
form: Solid
color: Yellow to Dark Yellow
InChI: InChI=1S/C12H17N3O5S/c13-21(18,19)10-1-2-11(12(7-10)15(16)17)14-8-9-3-5-20-6-4-9/h1-2,7,9,14H,3-6,8H2,(H2,13,18,19)
InChIKey: HNQRHNYBVWICKB-UHFFFAOYSA-N
SMILES: C1(S(N)(=O)=O)=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1
CAS DataBase Reference: 1228779-96-1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 132849
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Purity: 97%
Packaging: 5g
Price: $62
Updated: 2021/12/16

Apolloscientific

Product number: OR55052
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H69-1-7N
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: 0022AP
Product name: 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging: 1g
Price: $77
Updated: 2021/12/16

ChemScene

Product number: CS-0010860
Product name: 3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide
Packaging: 10g
Price: $84
Updated: 2021/12/16

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Usage,Production

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.

References

[1] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0116; 0117; 0118
[2] Patent: WO2017/156398, 2017, A1. Location in patent: Paragraph 0322
[3] Patent: WO2010/65865, 2010, A2. Location in patent: Page/Page column 226-227
[4] Patent: US2010/160322, 2010, A1. Location in patent: Page/Page column 86
[5] Patent: US2010/305122, 2010, A1. Location in patent: Page/Page column 118

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Suppliers

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Changzhou Nuobailang Biomedical Technology Co., Ltd.

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Hangzhou Chemtrue Bio-Tech Co.,Ltd.

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Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 1228779-96-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-05-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide 1228779-96-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

Hangzhou ICH Biofarm Co., Ltd

Product: 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide 1228779-96-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-30

1228779-96-1, 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMideRelated Search:

FETAL BOVINE SERUM USA ORIGIN GAMMA DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE Apalutamide 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 4-Bromo-2-fluoro-N-methylbenzamide 2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

THP-sulfonamide

3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide

abt-1－199

3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide

Venclexta Impurity 2

3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide

124267

Venetoclax Intermediate

Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]-

ABT-199 intermedate3

EOS-60659

Venetoclax Intermediate 4

3-nitro-4-(((tetrahydro-2H-pyran-4 yl)methyl)amino)benzenesulfonamide(For export only)

3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesu...

3-nitro-4-(((tetrahyydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide

2-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide

3-Nitro-4-[[(Tetrahydropyran-4-base)methyl]amino]Benzenesulfonamide

Venetoclax Inter.

1228779-96-1

1629047-84-9

1228779-96-1