5-Amino-3-(trifluoromethyl)picolinonitrile

Product Name: 5-Amino-3-(trifluoromethyl)picolinonitrile
CAS No.: 573762-62-6
Chemical Name: 5-Amino-3-(trifluoromethyl)picolinonitrile
Synonyms: 5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile;Apatamide intermediate;Apalutamide Impurity 19;5-Amino-3-(trifluoromethyl)2-cyanopyridine;5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE;5-AMino-3-(trifluroMethyl) picolinonitrile;2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine;5-Amino-2-cyano-3-(trifluoromethyl)pyridine;5-amino-3 - (trifluoromethyl) cyanopyridine;5-Amino-3-(trifluoromethyl)picolinonitrile 97%
CBNumber: CB92611517
Molecular Formula: C7H4F3N3
Formula Weight: 187.12
MOL File: 573762-62-6.mol

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5-Amino-3-(trifluoromethyl)picolinonitrile Property

Boiling point:: 362.2±42.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: -1.52±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C7H4F3N3/c8-7(9,10)5-1-4(12)3-13-6(5)2-11/h1,3H,12H2
InChIKey: WLMSCOVORZUSNW-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(N)C=C1C(F)(F)F

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Safety

RIDADR: 3439
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC53326
Product name: 5-Amino-3-(trifluoromethyl)picolinonitrile
Purity: 97%
Packaging: 1g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA103833
Product name: 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
Packaging: 100mg
Price: $80
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-3-76
Product name: 5-Amino-3-(trifluoromethyl)picolinonitrile
Purity: 97%
Packaging: 1g
Price: $128
Updated: 2021/12/16

Apolloscientific

Product number: PC53326
Product name: 5-Amino-3-(trifluoromethyl)picolinonitrile
Purity: 97%
Packaging: 5g
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA103833
Product name: 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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5-Amino-3-(trifluoromethyl)picolinonitrile Chemical Properties,Usage,Production

Uses

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is a pyridine heterocyclic organic compound, which can be used as pharmaceutical intermediates.

Synthesis

573762-57-9

573762-62-6

General procedure for the synthesis of 5-amino-3-(trifluoromethyl)cyanopyridine from 2-cyano-5-nitro-3-(trifluoromethyl)pyridine: 2-cyano-3-(trifluoromethyl)-5-nitropyridine A10 (0.095 g, 0.44 mmol) was reacted with powdered iron (0.112 g, 2 mmol) in a mixed solvent of ethyl acetate (1 ml) and acetic acid (1 ml) The reaction was heated for 15 hours in a mixture of ethyl acetate (1ml) and acetic acid (1ml). After completion of the reaction, the solid particles were removed by diatomaceous earth filtration and the filtrate was concentrated. Finally, the target compound A11 (0.075 g, 0.4 mmol, 91% yield) was purified by column chromatography (eluent: EtOAc:pentane=1:1).

References

[1] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0040; 0047
[2] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 11; 12; 19
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 47-48
[4] Patent: US2016/152592, 2016, A1. Location in patent: Paragraph 0073; 0080; 0081
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2803 - 2806

5-Amino-3-(trifluoromethyl)picolinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-3-(trifluoromethyl)picolinonitrile Suppliers

China 266 India 9 United Kingdom 2 United States 7 Global 284

Jiangxi Jinfeng Pharmaceutical Co., Ltd

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Energy Chemical

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View Lastest Price from 5-Amino-3-(trifluoromethyl)picolinonitrile manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile 573762-62-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-19

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile 573762-62-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Amino-3-(trifluoromethyl)picolinonitrile 573762-62-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrileRelated Search:

1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol Apalutamide N/A 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate ABT-199 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4-Bromo-2-fluoro-N-methylbenzamide

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE

5-Amino-3-(trifluoromethyl)picolinonitrile 97%

5-AMino-3-(trifluroMethyl) picolinonitrile

5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile

5-Amino-3-(trifluoromethyl)2-cyanopyridine

5-Amino-2-cyano-3-(trifluoromethyl)pyridine

5-amino-3-((trifluoromethyl))-pyridin-2-carbonitrile

5-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile

2-Pyridinecarbonitrile, 5-amino-3-(trifluoromethyl)-

5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile(For export only)

2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine

Apalutamide Impurity 19

5-amino-3 - (trifluoromethyl) cyanopyridine

Apatamide intermediate

5-Amino-3-(trifluoromethyl) picolinonitrile/ Apalutamide intermediate

5-Amino-3-(trifluoromethyl)pyridinecarbonitrile

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 98+

573762-62-6

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