ChemicalBook > CAS DataBase List > 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Product Name
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
CAS No.
1228779-96-1
Chemical Name
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Synonyms
124267;abt-1－199;EOS-60659;THP-sulfonamide;Venetoclax Inter.;Venclexta Impurity 2;ABT-199 intermedate3;Venetoclax Intermediate;Venetoclax Intermediate 4;3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide
CBNumber
CB02735683
Molecular Formula
C12H17N3O5S
Formula Weight
315.35
MOL File
1228779-96-1.mol
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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Property

Melting point:
188 - 191°C
Boiling point:
542.0±60.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.58±0.60(Predicted)
form 
Solid
color 
Yellow to Dark Yellow
InChI
InChI=1S/C12H17N3O5S/c13-21(18,19)10-1-2-11(12(7-10)15(16)17)14-8-9-3-5-20-6-4-9/h1-2,7,9,14H,3-6,8H2,(H2,13,18,19)
InChIKey
HNQRHNYBVWICKB-UHFFFAOYSA-N
SMILES
C1(S(N)(=O)=O)=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1
CAS DataBase Reference
1228779-96-1
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
132849
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Purity
97%
Packaging
5g
Price
$62
Updated
2021/12/16
Apolloscientific
Product number
OR55052
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$66
Updated
2021/12/16
SynQuest Laboratories
Product number
8H69-1-7N
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$72
Updated
2021/12/16
AK Scientific
Product number
0022AP
Product name
3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
Packaging
1g
Price
$77
Updated
2021/12/16
ChemScene
Product number
CS-0010860
Product name
3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide
Packaging
10g
Price
$84
Updated
2021/12/16
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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Usage,Production

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).

Uses

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Synthesis

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.

References

[1] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0116; 0117; 0118
[2] Patent: WO2017/156398, 2017, A1. Location in patent: Paragraph 0322
[3] Patent: WO2010/65865, 2010, A2. Location in patent: Page/Page column 226-227
[4] Patent: US2010/160322, 2010, A1. Location in patent: Page/Page column 86
[5] Patent: US2010/305122, 2010, A1. Location in patent: Page/Page column 118

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Suppliers

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View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 1228779-96-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide 1228779-96-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-11
Hangzhou ICH Biofarm Co., Ltd
Product
3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide 1228779-96-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-06-30

1228779-96-1, 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMideRelated Search:

FETAL BOVINE SERUM USA ORIGIN GAMMA DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE Apalutamide 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride 4-Bromo-2-fluoro-N-methylbenzamide 2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde

  • 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
  • THP-sulfonamide
  • 3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide
  • abt-1－199
  • 3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide
  • Venclexta Impurity 2
  • 3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide
  • 124267
  • Venetoclax Intermediate
  • Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]-
  • ABT-199 intermedate3
  • EOS-60659
  • Venetoclax Intermediate 4
  • 3-nitro-4-(((tetrahydro-2H-pyran-4 yl)methyl)amino)benzenesulfonamide(For export only)
  • 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesu...
  • 3-nitro-4-(((tetrahyydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
  • 2-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
  • 3-Nitro-4-[[(Tetrahydropyran-4-base)methyl]amino]Benzenesulfonamide
  • Venetoclax Inter.
  • 1228779-96-1
  • 1629047-84-9
  • 1228779-96-1