ChemicalBook > CAS DataBase List > CI 1020

CI 1020

Product Name
CI 1020
CAS No.
162256-50-0
Chemical Name
CI 1020
Synonyms
CI 1020;PD 156707;3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone;2(5H)-Furanone, 3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-
CBNumber
CB81873005
Molecular Formula
C28H26O9
Formula Weight
506.5
MOL File
162256-50-0.mol
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CI 1020 Property

storage temp. 
Store at +4°C
solubility 
Soluble to 50 mM in DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2942
Product name
CI1020
Purity
≥98%(HPLC)
Packaging
10
Price
$217
Updated
2021/12/16
Tocris
Product number
2942
Product name
CI1020
Purity
≥98%(HPLC)
Packaging
1
Price
$100
Updated
2021/12/16
Tocris
Product number
2942
Product name
CI1020
Purity
≥98%(HPLC)
Packaging
50
Price
$851
Updated
2021/12/16
TRC
Product number
C432680
Product name
CI1020
Packaging
10mg
Price
$165
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010272
Product name
3-(1,3-BENZODIOXOL-5-YL)-5-HYDROXY-5-(4-METHOXYPHENYL)-4-[(3,4,5-TRIMETHOXYPHENYL)METHYL]-2-(5H)FURANONE
Purity
95.00%
Packaging
100MG
Price
$1963.5
Updated
2021/12/16
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CI 1020 Chemical Properties,Usage,Production

Uses

A novel endothelin-A receptor antagonist, in hypoxic pulmonary hypertension.

Biological Activity

Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.

in vivo

CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4].

Animal Model:normal rats [2]
Dosage:30 mg/kg
Administration:oral administration (p.o.)
Result:Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats.
Animal Model:basal blood pressure in normotensive rats[4]
Dosage:40 mg/kg/day
Administration:oral administration (p.o.)
Result:Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia.
Lowered the increase in pulmonary resistance in isolated perfused lungs significantly.

IC 50

ETA: 0.3 nM (IC50)

CI 1020 Preparation Products And Raw materials

Raw materials

Preparation Products

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CI 1020 Suppliers

Canada 1 China 24 United Kingdom 2 United States 7 Global 34
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
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12952
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

162256-50-0, CI 1020Related Search:

2-PHENYL-2-PENTENAL 3,4-(METHYLENEDIOXY)PHENYLACETIC ACID 4-phenyl-3-buten-2-ol Ethyl 2-phenylacrylate ANISYL PHENYLACETATE BENZYL TIGLATE 5-HYDROXY-4-METHYL-2(5H)FURANONE 2-METHYL-1-PHENYL-2-PROPEN-1-OL ETHYL HOMOVANILLATE ETHYL 3-METHOXYPHENYLACETATE BENZYL 3-HYDROXYPHENYLACETATE BENZYL PHENYLACETATE ETHYL 4-METHOXYPHENYLACETATE Elemicin ethyl 3-hydroxyphenylacetate CI 1020 3-(3,5-DIMETHOXYPHENYL)-2-METHYL-1-PROPENE ETHYL 3,4-DIHYDROXYPHENYLACETATE

  • 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
  • CI 1020
  • PD 156707
  • 2(5H)-Furanone, 3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-
  • 162256-50-0
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  • Heterocycles
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  • Pharmaceuticals