5-HYDROXY-4-METHYL-2(5H)FURANONE

Product Name: 5-HYDROXY-4-METHYL-2(5H)FURANONE
CAS No.: 40834-42-2
Chemical Name: 5-HYDROXY-4-METHYL-2(5H)FURANONE
Synonyms: 5-hydroxy-4-methylfuran-2(5H)-one;Isotretinoin Ring;5-hydroxy-4-methly-2(5H);5-HYDROXYDODECANOIC LACTONE;γ-Hydroxy-β-Methylbutenolide;5-TYDROXY-4-METHYL-1-FURANONE;5-Hydroxy-4-Methyl-2(5H)-Furan;-Hydroxy-4-Methyl-2(5H)Furanone;5-HYDROXY-4-METHYL-2(5H)FURANONE;5-hyrdoxy-4-methyl-2(5H)furanone
CBNumber: CB7378649
Molecular Formula: C5H6O3
Formula Weight: 114.1
MOL File: 40834-42-2.mol

More

Less

5-HYDROXY-4-METHYL-2(5H)FURANONE Property

Boiling point:: 113 °C(Press: 0.05 Torr)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO, Methanol (Slightly)
form: Yellow to Dark Yellow
pka: 10.04±0.40(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C5H6O3/c1-3-2-4(6)8-5(3)7/h2,5,7H,1H3
InChIKey: XRNPHZPFAWLRNJ-UHFFFAOYSA-N
SMILES: O1C(O)C(C)=CC1=O
CAS DataBase Reference: 40834-42-2(CAS DataBase Reference)

More

Less

Safety

HS Code: 2932190090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More

Less

N-Bromosuccinimide Price

TRC

Product number: H947030
Product name: 5-Hydroxy-4-methyl-2(5H)-furanone
Packaging: 1g
Price: $100
Updated: 2021/12/16

TRC

Product number: H947030
Product name: 5-Hydroxy-4-methyl-2(5H)-furanone
Packaging: 5g
Price: $140
Updated: 2021/12/16

TRC

Product number: H947030
Product name: 5-Hydroxy-4-methyl-2(5H)-furanone
Packaging: 50g
Price: $625
Updated: 2021/12/16

TRC

Product number: H947030
Product name: 5-Hydroxy-4-methyl-2(5H)-furanone
Packaging: 100g
Price: $1090
Updated: 2021/12/16

Matrix Scientific

Product number: 126218
Product name: 5-Hydroxy-4-methylfuran-2(5H)-one
Purity: >95%
Packaging: 1g
Price: $90
Updated: 2021/12/16

More

Less

5-HYDROXY-4-METHYL-2(5H)FURANONE Chemical Properties,Usage,Production

Chemical Properties

Brownish Yellow Semi Solid

Uses

5-Hydroxy-4-methyl-2(5H)-furanone is a non-halogenated furanone used in studies to verify the mutagenicity of halogen substituted furanones.

Synthesis

616-02-4

931-23-7

40834-42-2

Under nitrogen protection, 5.34 g (21.00 mmol) LiAlH(t-BuO)3 was dissolved in 40 cm3 anhydrous THF and added dropwise to a solution of 1.68 g (15.00 mmol) citraconic anhydride dissolved in 50 cm3 anhydrous THF over a period of 30 min, and the reaction temperature was maintained at -30 °C. After the dropwise addition was completed, the temperature of the reaction system was raised to -15°C and maintained for 3 hours. Subsequently, the reaction mixture was slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with 50 cm3 1M HCl solution, followed by washing with saturated NaCl solution and extraction of the crude product with EtOAc (3 x 50 cm3). The organic phases were combined and dried with MgSO? The solvent was removed by concentration under reduced pressure to give the crude product. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=80:20) afforded 5-hydroxy-3-methylfuran-2(5H)-one (7a, 1.023 g, 60% yield) and 4-methyl-5-hydroxyfuran-2-one (7b, 116 mg, 7% yield) as yellow oils, respectively.TLC analysis (unfolding agent: petroleum ether/ethyl acetate= 80:20) showed that the Rf values of 7a and 7b were 0.16 and 0.15, respectively. 1H NMR (400 MHz, acetone-d6) δ of 7a: 6.67 (bs, 1H), 6.02 (bs, 1H), 5.87 (p, J = 1.5 Hz, 1H), 2.08 (d, J = 1.5 Hz, 3H) ppm; 13C NMR (100 MHz, acetone-d6) ppm. MHz, acetone-d6) δ: 171.30 (C), 166.65 (C), 118.68 (CH), 100.25 (CH), 13.15 (CH3) ppm; MS (EI): m/z (%) = 114.0 ([M]+, 2), 113.0 (7), 86.0 (61), 85.0 (13), 69.0 ( 100), 68.0 (82), 41.1 (50), 40.1 (65), 39.1 (93).

References

[1] Monatshefte fur Chemie, 2018, vol. 149, # 8, p. 1475 - 1480

5-HYDROXY-4-METHYL-2(5H)FURANONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-HYDROXY-4-METHYL-2(5H)FURANONE Suppliers

Canada 1 China 131 Europe 1 Germany 1 India 5 Slovakia 1 United Kingdom 4 United States 16 Global 160

Jinan Xinwei Pharmaceutical Technology Co., LTD

Tel: 18354101831 13305414159
Email: 2067831699@qq.com
Country: China
ProdList: 34
Advantage: 58

Jinan Junhe Pharmaceutical Co., Ltd

Tel: 18653300596
Email: 3989432235@qq.com
Country: China
ProdList: 289
Advantage: 58

nanjing

Tel: 13376082704 13376084917;
Email: 3930959291@qq.com
Country: China
ProdList: 2080
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

More

Less

View Lastest Price from 5-HYDROXY-4-METHYL-2(5H)FURANONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-HYDROXY-4-METHYL-2(5H)FURANONE 40834-42-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: KG
Release date: 2025-09-17

Shaanxi Dideu New Materials Co. Ltd

Product: 5-HYDROXY-4-METHYL-2(5H)FURANONE 40834-42-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

Shaanxi Dideu New Materials Co. Ltd

Product: 5-HYDROXY-4-METHYL-2(5H)FURANONE 40834-42-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-17

40834-42-2, 5-HYDROXY-4-METHYL-2(5H)FURANONERelated Search:

Ethyl furaneol 5-HYDROXY-4-METHYL-2(5H)FURANONE Atractylenolide III 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE Homofuraneol 3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone 4-HYDROXY-5-METHYL-3(2H)-FURANONE FEMA NO.3635 4-HYDROXY-5-METHYL-3(2H)-FURANONE,norfuraneol,4-hydroxy-5-methyl-3-(2H)-furanone 4-Hydroxy-5-methyl-2(5H)-furanone Isotretinoin 4-METHYL-2(5H)-FURANONE CI 1020 2-HYDROXY-5-OXO-2,5-DIHYDRO-FURAN-3,4-DICARBOXYLIC ACID DIMETHYL ESTER MANOALIDE LUFFARIELLOLIDE 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone 4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE RUBRATOXINA

(R,S)-5-Hydroxy-4-methyl-5H-furan-2-one

4-Methyl-5-hydroxy-2(5H)-furanone

5-HYDROXY-4-METHYL-2(5H)FURANONE

2(5H)-FURANONE, 5-HYDROXY-4-METHYL

5-HYDROXY-4-METHYL-5H-FURAN-2-ONE

5-Hydroxy-4-Methyl-2(5H)-Furan

5-HYDROXYDODECANOIC LACTONE

2(5H)-FURANONE, 5-HYDROXY-4-METHYL (INTERMEDIATES OF ISOTRETINOIN)

5-hydroxy-4-methylfuran-2(5H)-one

4-Hydroxy-3-Methylbut-2-en-4-olide

γ-Hydroxy-β-Methylbutenolide

5-hyrdoxy-4-methyl-2(5H)furanone

5-hydroxy-4-methyl-2,5-dihydrofuran-2-one

-Hydroxy-4-Methyl-2(5H)Furanone

2-hydroxy-3-methyl-2H-furan-5-one

5-TYDROXY-4-METHYL-1-FURANONE

Isotretinoin Ring

5-hydroxy-4-methly-2(5H)

40834-42-2

4083-44-2

40834-44-2

C5H6O3

Intermediates of Isotretinoin