LUFFARIELLOLIDE

Product Name: LUFFARIELLOLIDE
CAS No.: 111149-87-2
Chemical Name: LUFFARIELLOLIDE
Synonyms: LUFFARIELLOLIDE;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
CBNumber: CB0200705
Molecular Formula: C25H38O3
Formula Weight: 386.57
MOL File: 111149-87-2.mol

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LUFFARIELLOLIDE Property

Boiling point:: 541.7±50.0 °C(Predicted)
Density: 1.006±0.06 g/cm3(Predicted)
solubility: DMSO: soluble; Ethanol: soluble
pka: 9.98±0.40(Predicted)
form: Pale yellow oil.
InChI: InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey: JPWPYTMXSXYUPG-QZPYEDBESA-N
SMILES: O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14902
Product name: Luffariellolide
Purity: ≥98%
Packaging: 1mg
Price: $186
Updated: 2024/03/01

TRC

Product number: L473753
Product name: Luffariellolide
Packaging: 0.5mg
Price: $360
Updated: 2021/12/16

Usbiological

Product number: 453957
Product name: Luffariellolide
Packaging: 500ug
Price: $708
Updated: 2021/12/16

AK Scientific

Product number: 1118CP
Product name: Luffariellolide
Packaging: 1mg
Price: $262
Updated: 2021/12/16

ApexBio Technology

Product number: C5100
Product name: Luffariellolide
Packaging: 1mg
Price: $166
Updated: 2021/12/16

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LUFFARIELLOLIDE Chemical Properties,Usage,Production

Uses

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]

Uses

Luffariellolide is an anti-inflammatory PLA2?inhibitor.

Definition

ChEBI: Luffariellolide is a diterpene lactone.

LUFFARIELLOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LUFFARIELLOLIDE Suppliers

China 34 Switzerland 1 United States 7 Global 42

Shanghai EFE Biological Technology Co., Ltd.

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Changzhou Bojia Biomedical Technology Co., Ltd.

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111149-87-2, LUFFARIELLOLIDERelated Search:

Citicoline sodium U-73343 Phosphatidylinositol (Soy) SodiuM 2-Heptadecanone OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE Thioetheramide PC UMBELLIFERYL ARACHIDONATE 5-HYDROXY-4-METHYL-2(5H)FURANONE GERANIC ACID (E,E)-Farnesol FEMA 3766 CITRAL ETHYL CITRAL FARNESAL GERANYLGERANIOL MANOALIDE LUFFARIELLOLIDE

LUFFARIELLOLIDE

4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone

4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one

3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one

2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-

111149-87-2