1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE

Product Name: 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS No.: 116457-99-9
Chemical Name: 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms: THIOETHERAMIDE PC;WLWWVTPUDQTUJU-KDXMTYKHSA-N;Thioetheramide phosphorylcholine;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-
CBNumber: CB1453968
Molecular Formula: C45H93N2O4PS
Formula Weight: 789.27
MOL File: 116457-99-9.mol

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1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO;Soluble in dimethyl formamide
form: White solid.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 62750
Product name: Thioetheramide-PC
Purity: ≥95%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 62750
Product name: Thioetheramide-PC
Purity: ≥95%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 62750
Product name: Thioetheramide-PC
Purity: ≥95%
Packaging: 25mg
Price: $308
Updated: 2024/03/01

ApexBio Technology

Product number: C4894
Product name: Thioetheramide-PC
Packaging: 25mg(solution)
Price: $533
Updated: 2021/12/16

ApexBio Technology

Product number: C4894
Product name: Thioetheramide-PC
Packaging: 5mg(solution)
Price: $138
Updated: 2021/12/16

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1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties,Usage,Production

Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A₂ (sPLA₂). The IC₅₀ value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA₂, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

References

[1] yu l, deems r a, hajdu j, et al. the interaction of phospholipase a2 with phospholipid analogues and inhibitors[j]. journal of biological chemistry, 1990, 265(5): 2657-2664.
[2] balsinde j, balboa m a, insel p a, et al. regulation and inhibition of phospholipase a2[j]. annual review of pharmacology and toxicology, 1999, 39(1): 175-189.
[3] mallat z, lambeau g, tedgui a. lipoprotein-associated and secreted phospholipases a2 in cardiovascular disease[j]. circulation, 2010, 122(21): 2183-2200.

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Suppliers

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116457-99-9, 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINERelated Search:

U-73343 Phosphatidylinositol (Soy) SodiuM Citicoline sodium 2-Heptadecanone ARISTOLOCHIC ACID SODIUM SALT ISOTETRANDRINE 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE UMBELLIFERYL ARACHIDONATE LUFFARIELLOLIDE phosphorylcholine PALMITOYLISOPROPYLAMIDE 3-Aminopropylphosphonic acid Octadecanethiol Thioetheramide PC OCTADECYLMETHYLSULFIDE ETHYL OCTADECYL SULFIDE

1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE

1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE

THIOETHERAMIDE PC

Thioetheramide phosphorylcholine

WLWWVTPUDQTUJU-KDXMTYKHSA-N

3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-

116457-99-9

C40H83N2O5PS