TLCK

Product Name: TLCK
CAS No.: 4238-41-9
Chemical Name: TLCK
Synonyms: TLCK;TLCK HCL;TOS-LYS-CMK HCL;TLCK HYDROCHLORIDE;TOS-LYS-CHLOROMETHYLKETONE HCL;TOSYL-L-LYSYL-CHLOROMETHANE HCL;TOSYL-L-LYSINE CHLOROMETHYLKETONE HCL;N-ALPHA-TOSYL-LYS-CHLOROMETHYLKETONE HCL;NALPHA-P-TOSYL-L-LYSIN CHLOROMETYL KETONE;Chloro-3-tosylamido-7-amino-2-heptanone-HCl
CBNumber: CB8197728
Molecular Formula: C14H22Cl2N2O3S
Formula Weight: 369.3
MOL File: 4238-41-9.mol

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TLCK Property

Melting point:: ~165 °C (dec.)
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL
form: powder
color: white to pink
Water Solubility: Soluble in water
InChI: 1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChIKey: YFCUZWYIPBUQBD-ZOWNYOTGSA-N
SMILES: [S](=O)(=O)(N[C@@H](CCCC[N+H3])C(=O)CCl)c1ccc(cc1)C.[Cl-]

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: XT5160000
F: 10-21
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 616382
Product name: Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
Purity: Inhibits trypsin-like serine proteinases.
Packaging: 50mg
Price: $116
Updated: 2025/07/31

Sigma-Aldrich

Product number: 616382
Product name: Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
Purity: Inhibits trypsin-like serine proteinases.
Packaging: 250mg
Price: $370
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: AAA0000624
Product name: N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $175.56
Updated: 2021/12/16

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TLCK Chemical Properties,Usage,Production

Uses

Inhibitor of papain and trypsin

Biological Activity

Cell permeable: no', 'EC50 = 80 μM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages', 'Primary Target
trypsin like proteases', 'Product does not compete with ATP.', 'Reversible: no

IC 50

Caspase-3: 12.0 μM (IC₅₀); Caspase-7: 19.3 μM (IC₅₀); Caspase-6: 54.5 μM (IC₅₀)

TLCK Preparation Products And Raw materials

Raw materials

Preparation Products

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TLCK Suppliers

China 24 Germany 3 India 1 Switzerland 1 United Kingdom 1 United States 8 Global 38

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25687
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Greenherbs Science and Technology Development Co., Ltd.

Tel: 010-61136123
Fax: +86 (10) 8857-9127
Email: pub02@greenherbs.com.cn
Country: China
ProdList: 4049
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Jiangsu Hongmin Pharmaceutical Co., Ltd.

Tel: 18221292452
Email: fannieliu@glschina.com
Country: China
ProdList: 6798
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81139210 +86-18192627656
Fax: +86-29-88380327
Email: 1059@dideu.com
Country: China
ProdList: 3589
Advantage: 58

SINO High Goal Chemical Technology Co., Ltd.

Tel: 021-57646680 18306277365
Email: guoxin@chembiobanksh.com
Country: China
ProdList: 2682
Advantage: 58

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View Lastest Price from TLCK manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: TLCK (Tosyl-L-lysyl-chloromethane hydrochloride) 4238-41-9
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-16

4238-41-9, TLCKRelated Search:

2-Heptanone N-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE (TLCK) Chymotrypsin A-CHYMOTRYPSIN TYPE VII-B BIOTINLABLED A ND TLCK TR A-CHYMOTRYPSIN TYPE VII TLCK TREATED TLCK,TLCK HCL,TLCK HYDROCHLORIDE,NALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE (TLCK) TLCK,TLCK HYDROCHLORIDE,TLCK HCL

TOS-LYS-CHLOROMETHYLKETONE HCL

TOS-LYS-CMK HCL

TOSYL-L-LYSINE CHLOROMETHYLKETONE HCL

TOSYL-L-LYSYL-CHLOROMETHANE HCL

TLCK HYDROCHLORIDE

TLCK HCL

TLCK

p-N-(7-amino-1-chloro-2-oxohept-3-yl)toluenesulphonamide

1-Chloro-3-tosylamido-7-amino-2-heptanoneHCl

Chloro-3-tosylamido-7-amino-2-heptanone-HCl

1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTA NONE HYDROCHLORIDE 98%

Tosyllysine Chloromethyl Ketone (hydrochloride)

TLCK (Tosyl-L-lysyl-chloromethane hydrochloride)

(3S)-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE

(3S)-7-AMINO-1-CHLORO-3-TOSYLAMINO-2-HEPTANONE HYDROCHLORIDE

1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE

1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE HYDROCHLORIDE

1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE

Nalpha-(p-Toluenesulfonyl)-DL-lysine chloromethyl ketone hydrochloride

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem

L-1-CHLORO-3-(4-TOSYLAMIDO)-7-AMINO-2-HEPTANONE HYDROCHLORIDE

L-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HCL

N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE

N-ALPHA-TOSYL-LYS CHLOROMETHYL KETONE, HYDROCHLORIDE

N-ALPHA-TOSYL-LYS-CHLOROMETHYLKETONE HCL

NALPHA-P-TOSYL-L-LYSIN CHLOROMETYL KETONE

N-ALPHA-P-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE

N-ALPHA-P-TOSYL-L-LYSIN CHLOROMETYL KETONE HCL

N-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE

P-TOLUENESULFONYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride

TLCK (Tosyl-L-lysyl-chloromethane hydrochloride), Trypsin inhibitor

N<sup>α</sup>-Tosyl-Lys Chloromethyl Ketone, Hydrochloride

N-(7-Amino-1-chloro-2-oxo-3-heptyl)-4-methylbenzenesulfonamide Hydrochloride

4238-41-9

C14H21ClN2O3SClH

BioChemical

Biochemicals and Reagents

Analytical Enzymes

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Type

Enzyme Inhibitors

Trypsin Inhibitors

Organic Covalent Modifiers