6-HYDROXY-2-NAPHTHYL DISULFIDE

Product Name: 6-HYDROXY-2-NAPHTHYL DISULFIDE
CAS No.: 6088-51-3
Chemical Name: 6-HYDROXY-2-NAPHTHYL DISULFIDE
Synonyms: DDD;DDD0;PIR 3.5;6,6'DDD (Analytical);AKOS BBS-00001974;TIMTEC-BB SBB005947;6′-Dithiodi(2-naphthol);6,6'-Dithiodi-2-naphthtol;6,6'-DITHIODI(2-NAPHTHOL)
CBNumber: CB8198578
Molecular Formula: C20H14O2S2
Formula Weight: 350.45
MOL File: 6088-51-3.mol

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6-HYDROXY-2-NAPHTHYL DISULFIDE Property

Melting point:: 226 °C
Boiling point:: 597.5±25.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: <26.28mg/ml in DMSO
form: powder to crystal
pka: 8.93±0.40(Predicted)
color: White to Brown
Merck: 14,2840
CAS DataBase Reference: 6088-51-3(CAS DataBase Reference)
EPA Substance Registry System: 2-Naphthalenol, 6,6'-dithiobis- (6088-51-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2908990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D0244
Product name: Bis(6-hydroxy-2-naphthyl) Disulfide
Purity: >95.0%(HPLC)
Packaging: 1g
Price: $114
Updated: 2024/03/01

Tocris

Product number: 4212
Product name: PIR3.5
Purity: ≥98%(HPLC)
Packaging: 10
Price: $115
Updated: 2021/12/16

Tocris

Product number: 4212
Product name: PIR3.5
Purity: ≥98%(HPLC)
Packaging: 50
Price: $388
Updated: 2021/12/16

Usbiological

Product number: 256259
Product name: PIR 3.5
Packaging: 10mg
Price: $366
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD67127
Product name: 2,2'-Dihydroxy-6,6'-dinaphthyldisulphide
Packaging: 500mg
Price: $60
Updated: 2021/12/16

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6-HYDROXY-2-NAPHTHYL DISULFIDE Chemical Properties,Usage,Production

Description

DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.

Uses

For determination of protein-bound sulfhydryl groups.

Purification Methods

It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]

Toxicity evaluation

Animal Studies. DDD is less acutely toxic than DDT (29), with an oral LD₅₀ of 3400 to 4000 mg/kg in the rat and a dermal LD₅₀ ca. 1200 mg/kg in the rabbit. In a 2-year chronic dietary study in the rat, a LOEL of 100 ppm (5 mg/kg/day) was quoted for tissue damage, similar to that produced by DDT.
Human Studies. Most of the studies conducted in humans have used the o,p -isomer of DDD. This has been used as a drug, with medical and veterinary uses, for the treatment of Cushing’s syndrome and adrenal carcinoma, under the generic name of mitotane. After oral ingestion, o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the adrenal appears to be species-dependent, however, causing gross atrophy in the dog and reducing corticosteroid production without pathological effects in other mammals, including humans.

6-HYDROXY-2-NAPHTHYL DISULFIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-HYDROXY-2-NAPHTHYL DISULFIDE Suppliers

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6088-51-3, 6-HYDROXY-2-NAPHTHYL DISULFIDERelated Search:

Bis(2-methyl-3-furyl)disulfide 6-HYDROXY-2-NAPHTHYL DISULFIDE 100MG Dimethyl disulfide DIPHENYL DISULFIDE METHYL PHENYL DISULFIDE 2-Chloro-5-hydroxypyridine 6-HYDROXY-2-NAPHTHYL DISULFIDE

6,6'-Dithiodi-2-naphthtol

PIR 3.5

DDD (Analytical)

DDD 6,6'-Dihydroxy-2,2'-dinaphthyl Disulfide 6-Hydroxy-2-naphthyl Disulfide

2-Naphthalenol,6,6'-dithiobis-

6,6&apos

Bis(2-hydroxy-6-naphthyl) disulfide

TIMTEC-BB SBB005947

6,6’-dithiobis-2-naphthaleno

BIS(6-HYDROXY-2-NAPHTHYL) DISULFIDE

DDD

2,2'-DIHYDROXY-6,6'-DINAPHTHYL DISULFIDE

2,2'-DIHYDROXY-6,6'-DINAPHTHYLDISULPHIDE

6,6'-DITHIODI(2-NAPHTHOL)

6,6'-DIHYDROXY-2,2'-DINAPHTHYL DISULFIDE

6-HYDROXY-2-NAPHTHYL DISULFIDE

AKOS BBS-00001974

6-HYDROXY-2-NAPHTHYL DISULFIDE 98%

6-HYDROXY-2-NAPHTHYLDISULPHIDE

6-HYDROXY-2-NAPHTHYL DISULFIDE 98+%

6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6-Hydroxy-2-naphthyl disulfide, Bis(6-hydroxy-2-naphthyl) disulfide

2,2μ-Dihydroxy-6,6μ-dinaphthyl disulfide, 6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6,6μ-Dithiodi(2-naphthol), 6,6μ-Dithiodi-2-naphthol, Bis(2-hydroxy-6-naphthyl) disulfide, Bis(6-hydroxy-2-naphthyl) disulfide, DDD

[6,6'-Dithiodinaphthalene]-2,2'-diol

6,6'-Dithiobis(2-naphthol)

Bis(6-hydroxy-2-naphtyl) persulfide

DDD0

6-[(6-hydroxy-2-naphthalenyl)disulfanyl]-2-naphthalenol

6,6'-Disulfanediylbis(naphthalen-2-ol)

Bis(6-hydroxy-2-naphthyl) Disulfide &gt

6′-Dithiodi(2-naphthol)

6088-51-3

HOC10H6S2

C20H14O2S2

BioChemical

Biochemicals and Reagents

Sulfur Compounds (for Synthesis)

Detection

Fluorescent Probes, Labels, Particles and Stains

Sulfur Compounds (for Synthesis)

Synthetic Organic Chemistry