Description Source Background

MGMT, HUMAN

Description Source Background
Product Name
MGMT, HUMAN
Chemical Name
MGMT, HUMAN
Synonyms
AGT;MGMT;ANGT;AGT1;SPAT;TLH6;hFLT1;AGXT1;Ang III;Serpina
CBNumber
CB8200923
Formula Weight
0
MOL File
Mol file
More
Less

MGMT, HUMAN Property

storage temp. 
−20°C
form 
buffered aqueous glycerol solution
More
Less

Safety

Safety Statements 
23-24/25
WGK Germany 
1
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
485804
Product name
MGMT
Packaging
100ul
Price
$499
Updated
2021/12/16
Biorbyt Ltd
Product number
orb596929
Product name
MGMT
Packaging
10μg
Price
$290.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb528481
Product name
AGT
Packaging
10μg
Price
$290.7
Updated
2021/12/16
More
Less

MGMT, HUMAN Chemical Properties,Usage,Production

Description

MGMT Human Recombinant fused to a 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 227 amino acids (1-207) and having a molecular mass of 23.8 kDa.
The MGMT is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

MGMT is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and takes part in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. abnormal MGMT expression correlates with the prognosis in human solid cancers. MGMT decrease of expression is correlated with methylation. The human MGMT is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. MGMT promoter hypermethylation plays an important role in the early steps of colorectal carcinogenesis. Abnormal promoter hypermethylation of MGMT gene is associated with oral squamous cell carcinomas.

MGMT, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MGMT, HUMAN Suppliers

CHINA 30 Germany 1 Switzerland 2 United Kingdom 2 United States 3 Global 38
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74

MGMT, HUMANRelated Search:


  • Anti-MGMT, N-Terminal antibody produced in rabbit
  • MGMT (HUMAN) (RECOMBINANT)
  • AGT, HUMAN
  • O6-METHYLYGUANINE-DNA METHYLTRANSFERASE HUMAN
  • O6-METHYLGUANINE-DNA METHYLTRANSFERASE
  • MGMT
  • MGMT, HUMAN
  • O-6-METHYLGUANINE-DNA METHYLTRANSFERASE, HUMAN
  • AGT
  • 6-O- methylguanine-DNA methyltransferase
  • Methylated-DNA--protein-cysteine methyltransferase
  • O-6-methylguanine-DNA- alkyltransferase
  • Recombinant Human AGT Protein, His Tag
  • Recombinant Human MGMT Protein, His Tag
  • Human AGT Protein, His Tag
  • Ang III
  • Angiotensin 1-4
  • Angiotensin 1-8
  • Angiotensin 2-8
  • Angiotensin 3-8
  • Angiotensin-1
  • Angiotensin-3
  • hFLT1
  • Serpin A8
  • SERPINA8
  • ANGT
  • Serpin A
  • Serpina
  • AGT1
  • AGXT1
  • SPAT
  • TLH6