ChemicalBook > CAS DataBase List > ethyl 4-amino-6-chloronicotinate

ethyl 4-amino-6-chloronicotinate

Product Name
ethyl 4-amino-6-chloronicotinate
CAS No.
380626-81-3
Chemical Name
ethyl 4-amino-6-chloronicotinate
Synonyms
ethyl 4-amino-6-chloronicotite;ethyl 4-amino-6-chloronicotinate;4-aMino-6-chloro Nicotinic acid ethyl;ethyl 4-aMino-6-chloropyridine-3-carboxylate;4-aMino-6-chloropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-aMino-6-chloro-, ethyl ester
CBNumber
CB82047759
Molecular Formula
C8H9ClN2O2
Formula Weight
200.62
MOL File
380626-81-3.mol
More
Less

ethyl 4-amino-6-chloronicotinate Property

Boiling point:
335.8±37.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.75±0.42(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C8H9ClN2O2/c1-2-13-8(12)5-4-11-7(9)3-6(5)10/h3-4H,2H2,1H3,(H2,10,11)
InChIKey
OAQIVHCEAFDMTK-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(N)=C1C(OCC)=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

TRC
Product number
E899940
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
50mg
Price
$130
Updated
2021/12/16
TRC
Product number
E899940
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
100mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
250mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
100mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-D1090
Product name
Ethyl4-amino-6-chloronicotinate
Packaging
1g
Price
$266
Updated
2021/12/16
More
Less

ethyl 4-amino-6-chloronicotinate Chemical Properties,Usage,Production

Uses

Ethyl 4-Amino-6-chloronicotinate is a useful reagent in the preparation of biologically active small molecules with pharmaceutical application.

Synthesis

1588423-42-0

380626-81-3

Ethyl 6-chloro-4-((2,4-dimethoxybenzyl)amino)nicotinate (15 g, 42.8 mmol) was used as a raw material, which was mixed with trifluoroacetic acid (TFA, 80 mL), heated to 50 °C and the reaction was maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed under reduced pressure. The pH of the residue was adjusted to 8 with aqueous sodium bicarbonate (NaHCO3) and then extracted with ethyl acetate (EtOAc). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=4:1) to afford the target product ethyl 4-amino-6-chloronicotinate (5.1 g, 61% yield) as a white solid.

References

[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 218
[2] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 180-181

ethyl 4-amino-6-chloronicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ethyl 4-amino-6-chloronicotinate Suppliers

China 100 India 1 The Netherlands 1 United States 6 Global 108
Nanjing Nohon Biological Technology Co., Ltd.
Tel
025-85767923 18512596075
Fax
025-85767923
Email
sales@nuoxibio.com
Country
China
ProdList
962
Advantage
55
Nanjing ShinGen PharmTech Co.，Ltd
Tel
15365085396
Email
523576380@qq.com
Country
China
ProdList
560
Advantage
58
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Record Tech (Shanghai) Co., LTD
Tel
13761627472
Fax
86-21-64965863
Email
183009664@qq.com
Country
China
ProdList
649
Advantage
62
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3764
Advantage
58
Chiba Pharmaceutical Science and technology Co, Ltd.
Tel
0531-81313138 13066006660
Fax
QQ: 3366077777
Email
chibapharm@foxmail.com
Country
China
ProdList
3991
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Nantong Bosu Pharmaceutical Technology Co., Ltd.
Tel
0513-0513-51005092 13390947892
Fax
0513-51005092
Email
tashiyxy@163.com
Country
China
ProdList
839
Advantage
58
Taizhou FRIEND Chemical Co., Ltd.
Tel
025-0523-86200082 15380713688
Fax
0523-86200991
Email
Austin@fredchem.cn
Country
China
ProdList
151
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Xi'an NewProChem Co.,Ltd.
Tel
15332490153
Fax
QQ 2725398181
Email
newprochem@126.com
Country
China
ProdList
991
Advantage
55
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
ShangHai Wisacheam Pharmaceutical Co., Ltd.
Tel
13817485796
Fax
QQ:895624079
Email
tim@wisacheampharm.com
Country
China
ProdList
3592
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
+86 21 37023730
Email
info@carlowchem.com
Country
China
ProdList
1969
Advantage
50
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
0512-0512-52358471 17715136450
Fax
05125235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
12127
Advantage
58
shandong XuanHong Pharmaceutical Technology Co.,Ltd
Tel
+86-0531-88801869 15090917080
Fax
0531-88801867
Email
sciencechem@163.com
Country
China
ProdList
292
Advantage
55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Huaxing Biological Technology Co., Ltd.
Tel
18621295758
Fax
-QQ:1449085402
Email
1449085402@qq.com
Country
China
ProdList
1817
Advantage
55
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
Advantage
55
Shanghai Pingguo Pharmaceutical Co., Ltd.
Tel
021-20432229
Fax
QQ2412110556
Email
2412110556@qq.com
Country
China
ProdList
6017
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
4134
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
Cochemical Ltd.
Tel
029-86115547 17791676824
Fax
021-51602123
Email
sales@cochemical.com
Country
China
ProdList
4006
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai WangFa Chemical Technology Co., Ltd.
Tel
13918479294
Fax
-
Email
xiebenfa@163.com
Country
China
ProdList
4090
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9717
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Shanghai Yimiao Pharmaceutical Technology Co., Ltd.
Tel
18717991116
Fax
-
Email
1605896178@qq.com
Country
China
ProdList
250
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
9939
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9911
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Shanghai Songfan Pharmaceutical Technology Co., Ltd.
Tel
17321241880
Email
485229790@qq.com
Country
China
ProdList
1750
Advantage
58
LEADMEDPHARM CO.,LTD
Tel
13674959855 13674959855
Email
sales@synthontech.com
Country
China
ProdList
3035
Advantage
58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.
Tel
15990591583
Fax
qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country
China
ProdList
6108
Advantage
58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.
Tel
022-23989838 13810451150
Email
44766350@qq.com
Country
China
ProdList
2349
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
More
Less

View Lastest Price from ethyl 4-amino-6-chloronicotinate manufacturers

Career Henan Chemical Co
Product
ethyl 4-amino-6-chloronicotinate 380626-81-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1ton
Release date
2020-01-08
Career Henan Chemical Co
Product
ethyl 4-amino-6-chloronicotinate 380626-81-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

380626-81-3, ethyl 4-amino-6-chloronicotinateRelated Search:

Ethyl 5-broMo-6-chloropicolinate 3-Pyridinecarboxylic acid, 4-chloro-6-nitro-, ethyl ester Ethyl 6-chloro-2,4-diMethylnicotinate 4-Pyridinecarboxylic acid, 5-hydroxy-2-methyl-, ethyl ester Ethyl 6-broMo-2-chloronicotinate 3-Pyridinecarboxylic acid, 5-chloro-1,6-dihydro-1-methyl-6-oxo-, ethyl ester 5-Bromo-3-methylpyridine-2-carboxylic acid ethyl ester ethyl 5-chloro-3-fluoropicolinate Ethyl 5-bromo-2-chloroisonicotinate 2-Pyridinecarboxylic acid, 6-chloro-3-fluoro-, ethyl ester Ethyl 5-bromo-4,6-dichloronicotinate ethyl 4-cyano-2-pyridinecarboxylate ethyl 4-chloro-2-Methylnicotinate 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-

  • 4-aMino-6-chloropyridine-3-carboxylic acid ethyl ester
  • 4-aMino-6-chloro Nicotinic acid ethyl
  • 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-, ethyl ester
  • ethyl 4-aMino-6-chloropyridine-3-carboxylate
  • ethyl 4-amino-6-chloronicotinate
  • ethyl 4-amino-6-chloronicotite
  • 380626-81-3